Basics of Epigenetics | What is DNA methylation?
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Basics of Epigenetics | What is epigenetics?
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The most important epigenetic mechanism is DNA methylation. It has gained research interest because it has been the easiest to study and it plays an essential role in many biological processes, including chromosome inactivation, gene suppression, and genomic imprinting. Moreover,abnormal DNA methylation has been established to be associated with cancer. So what happens during DNA methylation is that the enzyme DNA Methyl Transferase transfer s a methyl group onto a portion of cytosine to form 5-methylcytosine. Methylation inhibits the expression of a gene by recruiting proteins that are involved in gene repression. Changes in the DNA methylation have been associated with aging and aging-related diseases. Currently, it is an established biomarker of biological age and a predictor of mortality and susceptibility to diseases. A study has been conducted to characterize the epigenetic molecular basis of the human hippocampus in Alzheimer's disease. Hippocampal samples were collected from a cohort of pure Alzheimer's disease patients and controls. Successively, genome-wide DNA methylation levels were profiled using methylation arrays. As a result, Alzheimer's disease related differentially methylated positions or DMPs were identified in the Alzheimer's disease hippocampus. Alzheimer's disease related DMPs were preferentially involved neurodevelopmental and neurogenesis-related genes.
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Can black seeds Nigella Sativa cure HIV? Reality or myth?
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Can black seeds Nigella Sativa cure HIV? Reality or myth?
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Black seed is the extraction of a herb. Its scientific name is Nigella Sativa. Famously it is also known as Kalonji in Arabic. It is a highly valued nutraceutical herb with a wide range of health benefits. In Arab countries, it is used for cooking. For centuries black seeds have been used in traditional medicine in India, and the Middle East. Its key ingredient and bioactive component is thymoquinone (TQ). Thymoquinone has the potential to attenuate oxidative stress and inflammation in the body. Nigella Sativa also improves cell survival, immunity, and energy metabolism in the human body. Black seeds are known to have diverse health benefits such as protection against metabolic, cardiovascular, respiratory, renal digestive, reproductive, hepatic, and neurological disorders. There have been myths and debates about the pharmaceutical use of black seeds against Acquired Immune Deficiency Syndrome (AIDS) caused by the Human Immunodeficiency Virus. People who believe in and practice herbal, homeopathic, and traditional medicine have always supported the fact that black seeds if mixed with honey, improve clinical and laboratory results of H-I-V patients. Whereas allopathic doctors and researchers always confronted this myth. Treatment of patients with AIDS has always been a big challenge for health professionals as there have been no definite treatment options available. There are 33.6 million people worldwide who are affected by AIDS. Recently by the use of H-A-A-R-T therapy, there is significant control over AIDS-related sub-infections and deaths. This is because H-A-A-R-T THERAPY directly acts on the different phases of the H-I-V replication cycle. It stops H-I-V replication. Hence an overall increase in the CD4 receptor cells in the patients suffering from AIDS. H-A-A-R-T THERAPY is effectively being used almost in every part of the world against AIDS. The United Nations directly controls this program through the World Health Organization ( WHO ). Whereas the application of black seeds against H-I-V has always been a myth. Clinical trials have been conducted. Initially, there was a significant rise in CD4 receptor cell count. But it was temporary.
In clinical trials, Nigella Sativa increased T helper cells and other leukocytes in rats. The accelerating wound healing effects of black seeds in humans have been accepted by scientists. It has anti-inflammatory properties and analgesic effects on the human body. However, its antiretroviral efficacy had not been supported by the clinical trials at Clinical Pharmacology Department, University College Hospital, Ibadan, Nigeria. This myth has been busted by Professor Doctor AbdulFatah AdekUnle Onifade. So the summary is that black seeds continue to be in medical use because of their immense pharmaceutical uses. And this herbal product still works for different allergies, wound healing effects, and relieves pain. But considering it as a potential agent to kill H-I-V and treat AIDS is still a myth. As this has not been supported by enough clinical trials and research.
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Ursolic acid
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Ursolic acid
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Ursolic acid is a natural triterpene compound that are found in various plant sources. Ursolic acid has been shown to have pharmacological effects including anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects. These effects are due to its ability to suppress nuclear factor-kappa B factor. Nuclear factor-kappa B is a central mediator of pro-inflammatory gene functions in immune cells. Nuclear factor-kappa B is an ubiquitous transcription factor that regulates a series of genes involved in many diseases associated with inflammation and immune system such as atherosclerosis, muscular dystrophy, stroke, and viral infections. In the brain. ursolic acid has been shown to play a protective role in various brain diseases caused by oxidative stress and excitotoxicity. Moreover, ursolic acid has been evidenced to suppress apoptotic signaling protecting the brain from ischemic stroke. Due to its ability to attenuate inflammation and oxidative stress, ursolic acid has been reported to prevent the depletion of glutathione in the hippocampus. It also has been reported to suppress the upregulation of interleukin 1 beta, interleukin 6, and tumor necrosis alpha factor levels in the hippocampus in mice. The amelioration of oxidative stress and inflammatory response in the hippocampus may offer a novel therapeutic strategy in treating Alzheimer's disease.
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AVOID THESE FOODS! Food that causes inflammation in the body | You are probably eating some of them
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Food that causes inflammation in the body
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Inflammation is the process in which our body responds to any foreign agent, insult, or injury. Foreign agents in the body can be microorganisms such as bacteria, fungi, viruses, and protozoans. Due to any of the outside causes, the body reacts by starting an inflammatory process. It is usually good for the body. Due to an inflammatory reaction, the healing process in the body starts. Our daily intake of foods and diets is directly related to the inflammatory processes in the body. Inflammation can be short-lived or chronic that persists for months and years. Foods that we take significantly affect inflammatory reactions in the body. Some disease conditions such as obesity, diabetes, cardiovascular complications, and IBD are correlated with intake of foods and inflammation in the body. There are certain foods such as sugar, high-yield corn syrup, trans fats, oils, refined carbohydrates, processed meat, and excessive alcohol intake that cause inflammation in the body. Sugar and high fructose corn syrups are leading causes of inflammation in the body. Table sugar has 55% sugar content in it. Similarly, corn syrup contains more than 50% fructose. These two are super rich in sugar. Which in turn acts as an antioxidant. Antioxidants aggravate inflammation. Soda drinks and fizzy drinks are rich sources of sugar. Sugar causes obesity, chronic kidney disease, cardiovascular diseases, and renal failure in the long run. Fructose is present in corn syrup. It causes insulin resistance. Similarly, pastries, cakes, doughnuts, and chocolates also cause inflammation in the body. Unsaturated trans fatty acids also induce inflammatory reactions in the body. Margarine, popcorn, french fries, and baked foods contain trans fats. So these foods should be taken with some caution. Soybean oil is the kind of vegetable oil that promotes inflammation. Similarly, Omega 6 are saturated fatty acids. These cause joint disorders such as arthritis and osteoporosis. Western diets are unfortunately rich in such fatty acids. Refined drinks are richly supplied with sugar content. Uncontrolled sugar causes diabetes, chronic kidney disease, and obesity. These complications are the outcome of Inflammatory reactions due to such diets.
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BE AWARE of these symptoms of lack of Vitamin B | PROTECT YOURSELF
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Symptoms of lack of Vitamin B
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Vitamin B is also called the Vitamin B complex. These are a total of eight vitamins each having different functions and roles to play in the body. Similarly, deficiency of each such vitamin leaves harmful effects on the human body. Generally, vitamin b provides energy and keeps the cell health intact. Therefore deficiency of these causes muscle weakness, low energy, and metabolic disturbance in the body. Pregnant women and older adults are at higher risk of developing vitamin B deficiencies. Symptoms vary from mild to severe depending on the type of vitamin B deficiency. Anaemia, skin rashes, confusion, and fatigue are some general symptoms of vitamin B deficiency. Certain diseases such as HIV, Crohn's disease, Celiac disease, e, and excessive alcoholism potentiate vitamin B deficiency in the body. Vitamin B12 is one of the most important vitamins in this group. It is required for neural health. Vitamin B12 deficiency is linked with megaloblastic anaemia, chronic fatigue, loss of appetite, recurrent constipation, and weight loss. B12 deficiency in the brain is manifested by the tingling sensation, poor memory, ulceration of the mouth, and issues with balancing the body. Vitamin B6 is the second most important vitamin in the vitamin B complex class of vitamins. Its other name is pyridoxine. It is required for boosting the immune system of the body. Pregnant and lactating women need more than another group of people. Pyridoxine helps in the formation of antibodies in the blood. Scratches on the general body surfaces, and rash are prominent symptoms of vitamin B 6 deficiency in the body. Depression, confusion, anaemia, and susceptibility to the infection is the leading cause of vitamin B6 deficiency in the body. B1 also known as thiamine deficiency is manifested in the body by the presence of cracks around the und angle of the mouth. Riboflavin is the name of Vitamin B2. Its deficiency causes fatty liver disease.
Niacin is another important vitamin in this class. It is known as Vitamin B3. It plays an important role in converting foods into rich energy reserves in the body. Symptoms of niacin deficiency are a hallucination, suicidal thoughts, constipation, and a bright red tongue. Niacin deficiency turns the color of skin into red or dark brown. One of the most important vitamins is Vitamin B9 or folate. It is required in pregnancy or blood cancers. The most common symptom of vitamin B9 is holoblastic anaemia. In heart it causes palpitations and irregular rhythms. It affects the lungs by damaging the lungs' parenchyma. It damages brain cells, so there is trouble in concentration and irritability. Mouth ulcers are also due to min B9 deficiency. Vitamin B complex is a very important vitamin required for optimal growth of our body. Its deficiencies are manifested by a vast range of symptoms. Deficiencies can be augmented by vitamin B supplements, fruits, and vegetables.
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Rifampicin and lifespan extension
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Rifampicin
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Rifampicin is an antibiotic drug that belongs to the class of rafamycins. Rifampicin was discovered in 1965 and has been used as a medication for the prevention and treatment of tuberculosis. Recently, rifampicin has been shown to increase lifespan in Caenorhabditis elegans by up to 60% through its ability to reduces advanced glycation end products or AGEs. AGEs are heterogeneous groups of molecules characterized by the combination of proteins or lipids with sugar in the bloodstream. The accumulation of AGEs in tissues has been proposed to alter the structure and function of proteins, which may contribute to the onset and progression of metabolic disorders and age-related diseases, as well as oxidative stress and inflammation associated with neurodegenerative diseases. The antiglycating activity of rifampicin is due to its ability to activate a transcription factor called DAF-16. It as been reported that the activation of DAF-16 leads to the upregulation of AGES detoxification system, which result in increased AGE disposal and a consequential increase in lifespan.
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AGEs are making you age faster | Discover today how to fight them and make you biologically younger
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Discover what AGEs are, why they make you age faster, and what to do in order to fight them
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Advanced Glycation End Products, AGEs, are a group of compounds that are formed when sugars react with proteins or lipids. When the level of AGEs increases, they start to trigger cellular damage by leading to lipid peroxidation and inflammation. The formation of AGEs is accelerated by food cooked at high temperature or fried in oil or fat.AGEs can be found in many foods, such as bread, potatoes, and other starchy foods. They can also be found in many processed foods like french fries and potato chips.The most common AGEs are glyoxal, methylglyoxal, and 3-deoxyglucosone. These AGEs have been linked to the development of chronic diseases such as diabetes mellitus type 2, cardiovascular disease and Alzheimer's disease.AGEs can also be created by cooking. They form in the body, and are found in high concentrations in foods that have been cooked at high temperatures.Advanced Glycation End Products contribute to the aging process significantly. On a molecular level, AGEs create cross-links between collagen and other proteins, which can lead to stiffening of the skin, hardening of the arteries, and even the development of arthritis. In addition, AGEs contribute to an increase in blood pressure, which can lead to heart attack or stroke. As previously mentioned, the same process that leads to stiffening of the skin also increases lines on the face and gives them a droopy appearance. These are just a few examples of how AGEs affect us on a cellular level contributing to the aging process.One of your goals if you want to fight aging is to reduce the production of AGEs.The AGEs that form in the body can be reduced by eating healthy, exercising, and taking supplements.Some of the supplements useful to fight AGEs are thiamine, also known as vitamin B1, Pyridoxamine, a derivative of vitamin B6, Carnosine and Alpha-lipoic acid.We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to a doctor or other professional before beginning any sort of supplementation or treatment. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Kill zombie cells today | Dasatinib plus Quercetin, senolytic drug combination | longevity science
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Kill zombie cells | Dasatinib plus Quercetin, senolytic drug combination | longevity science
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With age, all body tissues accumulate senescent cells, which secrete destructive enzymes and inflammatory proteins that affect nearby healthy cells. Senolytic drugs eliminate these deteriorated cells, leaving room for new cells to replace them. The idea is that removing senescent cells from a tissue will improve its function.Senolytic agents are derived from natural products, some of which are aimed at inhibiting the pro-survival pathways that make it possible for these cells to resist apoptosis, i.e. programmed cell death. Among these agents, known for their goodness in combating senescence, or cellular aging, we have quercetin and dasatinib.Quercetin is a flavonoid used in dietetics present in many vegetables, in addition to tea and red wine. in some varieties of onion, it can represent up to 10% of its dry weight and has many promising therapeutic activities.It is considered to have various biological activities such as antioxidant, anticarcinogenic, antiviral, antibacterial, anti-inflammatory and prevents cardiovascular diseases. It is therefore currently used as a nutritional supplement and phytochemical remedy for a wide range of diseases such as obesity, diabetes, and circulatory dysfunction, as well as to treat mood-related disorders.Quercetin is a natural compound that acts as an antihistamine and anti-inflammatory and eliminates human senescent endothelial cells and mouse bone marrow stem cells.Dasatinib is a tyrosine kinase inhibitor developed by the pharmaceutical industry as an alternative to the highly successful imatinib for the treatment of chronic myeloid leukemia when resistance develops. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.Dasatinib is also used to treat a certain type of acute lymphoblastic leukemia, a type of cancer of the white blood cells in people who can no longer benefit from other leukemia drugs or who cannot take these drugs because of side effects.The Kirkland group named these compounds senolytics.When Kirkland's group identified these compounds with senolytic activity, they did not stop at demonstrating their activity in cell culture but used them in animals that they irradiated (a treatment that causes tissue aging, as many cancer patients will attest), in mice that they allowed to age naturally, or in a genetic model of premature aging or progeria. In all these models, the combined treatment of quercetin and dasatinib showed that the animals were more protected from the effects related to aging pathologies.We would like to hear about your own opinion on this topic. Leave a comment. Lastly, remember that it is important to talk to a doctor or other professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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In the end THE ULTIMATE LIST OF THE VERY BEST SENOLYTICS | how to kill senescent / ZOMBIE CELLS |
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Best SENOLYTICS | how to kill senescent cells | senescence | Longevity science
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More and more scientists consider aging to be more or less a disease. Growing older has a direct biological effect: our body stores more and more damaged cells. The problem is that, as we get older, the immune system starts to fail and these damaged or senescent cells, those that lose their ability to divide, accumulate.
At the cellular level, aging is called senescence. However, this process goes beyond aging, placing senescent cells at the center of numerous cellular processes as disparate as the development of the organism or cancer.
As a consequence, inflammation levels increase (with the consequent risk of cancer) and the body secretes enzymes that are harmful to organ tissues. Decay, in short, accelerates. But it can be stopped. In other words, if we combat cell aging, we will also combat the diseases that result from it, such as cancer, Alzheimer's disease, osteoporosis or cardiovascular problems, which will come sooner or later.
There are already drugs that have been shown to prolong life. A senolytic is a drug that fights cellular aging, although by extension it is used to refer to any anti-aging compound. If you go to a pharmacy and ask for a senolytic, you will get a funny look on your face, because they are not sold, nor do they exist as such.
In reality, senolytics are drugs that have been invented for something else, but have proven to be very effective in slowing down the aging process. A senolytic agent is a compound with a wide variety of chemical structures, which can be obtained from natural products or by chemical synthesis, and is intended to provide senolytic therapy at three levels: 1. Specific destruction of senescent cells. 2. Inhibition or silencing of inflammatory factors. 3. Enhancement of the immune system for the elimination of senescent cells.
It is noted, for example, the possibility of alleviating the senescent cell burden, even if treatment was initiated at an advanced age, with fisetin. This natural compound - specifically, a flavonoid - is present in such common fruits as strawberries, persimmons, apples or blueberries.
Fisetin is one of the most promising senolytic drugs and has already shown its efficacy in halting Alzheimer's disease.
Another important compound is Curcumin.
Curcumin is a hydrophobic polyphenol found in the rhizome of turmeric (Curcuma longa). It has widely studied pharmacological activities such as anticancer, anti-inflammatory, antioxidant and antimicrobial. In addition, due to its polyphenolic nature, it has also been studied for its enormous therapeutic potential to delay aging, as well as prevention and treatment of age-related pathologies.
Up to date, a small number of natural compounds have been shown to display senolytic activity, but it is likely that this is the tip of an iceberg that will be exposed in the coming years. These include quercetin, fisetin, phloretin, and piperlongumine, and there are preliminary indications that tocotrienols may also display senolytic activity in particular models of cellular senescence.
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Would you do this futuristic treatment to help your Mitochondria fight aging | PGC1-alpha |
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PGC1 | Gene therapies that fight aging
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Nowadays, due to the existence of a large amount of easily accessible scientific information, it is common to get lost or feel mentally saturated when faced with such complex subjects as molecular biology or biochemistry. Here we will try to explain today topic in simple words.PGC1alpha is a macromolecule that plays a central role in the regulation of cellular energy metabolism. It stimulates mitochondrial biogenesis and participates in the regulation of both carbohydrate and lipid metabolism.It's very likely that PGC1alpha is strongly related to disorders like cardiomyopathy, obesity, and diabetes. PGC1alpha’s regulatory function in lipid metabolism, makes it an enticing option for pharmacological intervention for treating type 2 diabetes and obesity.For its part, the mitochondrion functions as a power plant: it has the capacity to use oxygen to burn the food it receives in a controlled manner, and thus obtain the energy we need to feel well, carry out all our daily activities, and supply the needs of all our organs.In short: our body's energy is produced in the mitochondria, an organelle located inside each cell that acts as a real engine, capable of manufacturing it for the body and mind to function properly and smoothly.Precisely, one of the primary identifiers of aging is when the mitochondria stop working properly. Similarly, if mitochondria fail, inflammatory processes are triggered and well-known metabolic diseases appear, from obesity to atherosclerosis, Alzheimer's disease, and even cancer.The most important difference between a normal cell and a tumor cell is the way it breathes, i.e. the way it generates energy. This was discovered by Otto Warburg in 1920, when he showed that damage to the mitochondria was associated with the development of cancer.Today we know that the mitochondrion not only orders metabolism and produces energy under normal conditions, but that it is also part of its functions to tell the cell when to reproduce and when to die.In addition to aging, what affects the health of mitochondria? lack of physical exercise and sedentary lifestyles, smoking and air pollution, excess fats and sugars in the diet and of course, stress.This leads to metabolic, immune, and bioenergetic changes that promote neoplastic processes, cardiovascular disease, metabolic syndrome, immune system dysfunction, and neurodegenerative disease, including mental health disorders, fatigue, autism, depression, and chronic stress, all of which have a significant mitochondrial energy dependence.As we explained above, PGC1alpha plays a highly important role in mitochondrial biogenesis. This is why science has developed ways of activating this macromolecule through gene therapy.Now you know their importance and why you should take this therapy into consideration.We would like to hear about your own opinion on this topic. Leave a comment. Lastly, remember that it is important to talk to a doctor or other professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Futuristic treatment to fight aging you can do today | Telomerase | Gene therapies that fight aging
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Telomerase | Gene therapies that fight aging
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Anti-aging seems to be among the newest goals of medicine and science. Every here and then, we see new anti-aging treatments, dietary supplements and so on that show promising results. After all, every decade, life expectancy increases by 2 years, and there are half a million people who are over 100 years old worldwide. So… how far can we stretch the limits of human life? Are we on the path to immortality?
There is an enzyme capable of conferring additional life to cells was a very promising finding in the development of anti-aging and even anti-cancer therapies.
Although it may seem like a science fiction movie, there is a molecule with the ability to extend life indefinitely, and you don't need to go very far to find it. It is inside your own organism, albeit at a microscopic level. Telomerase is an enzyme whose sole function is to confer additional life to cells. And how does it do that? By lengthening the ends of chromosomes, called telomeres.
The genetic information is stored in the chromosomes, i.e. the instructions that determine how everything in your body works: the color of your hair, the shape of your lips and also, the diseases you are most at risk of suffering from. Since its discovery in 1990, it has been proven that short telomeres are related to premature aging and higher incidence and mortality from cancer. It is also related to a weakened immune system, type 2 diabetes, elevated blood cholesterol levels, hypertension, cardiovascular disease, low bone density, dementia, and even infertility.
It is precisely because of cancer disease that we owe the discovery of Telomerase: in 2003, the American Elizabeth Blackburn, together with her team, was awarded the Nobel Prize in Medicine for proving how tumor cells were able to activate the action of telomerase to become immortal.
So, if there is an enzyme capable of lengthening telomeres, why do we suffer from diseases and die? In reality, telomerase activity is "deactivated" at birth. So, from then on, we are irremediably condemned to grow old and, ultimately, to die.
The good thing is that science and medicine are always advancing, so now, gene therapy with Telomerase are available in some countries. You can also up the production of this enzyme naturally with exercise, a good diet and overall healthy diets, but the gene therapy will always bring very good results in ways that nature can’t possibly do.
We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to a doctor or other professional before beginning any sort of supplementation or treatment. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Glucuronic acid level as biomarker of longevity and healthspan
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Glucuronic acid
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Glucuronic acid is an organic compound that belongs to a class of molecules called carboxylic acids. It is found in the body and helps the liver remove toxic substances from it. Glucuronic acid can be synthesized by humans through a process called glucuronidation, which occurs when certain enzymes react with alcohols or phenols.
Glucuronic acid is an important part of the human body because it helps to remove toxins from the body. Glucuronic acid can also be used to help with kidney stones and gout.
Glucuronic acid is also used in the synthesis of glycosaminoglycans, which are important for cartilage and bone formation.
A study on humans and mice has reported that circulating glucuronic acid is a robust biomarker of mortality that is conserved across species.
It has been found that glucuronic acid levels are significant predictors of all-cause mortality in three population-based cohorts from different countries, as well as in a longitudinal study of genetically heterogenous mice.
Additionally, it has been found that glucuronic acid levels increase with age and predict future healthspan-related outcomes.
Elevated serum levels of glucuronic acid have been reported in human studies of diabetes, hepatocellular carcinoma, hepatitis, cirrhosis, and obstructive jaundice.
All together, these results seem to demonstrate that glucuronic acid could be a robust biomarker of longevity and healthspan.
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The neuroprotective effect of ketone bodies
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The neuroprotective effect of ketone bodies
Ketone bodies are molecules synthesized primarily in the liver that act as primary energy source for the brain when circulating glucose is scarse. Ketone body synthesis can be synthesized in particular situations such as ketogenic diets and prolonged fasting. Recently, ketone bodies are also available commercially. Ketone bodies have been reported to have benefits in the metabolic functions of the brain of individuals with neurodegenerative diseases, including Alzheimer's disease. Alzheimer's disease is characterized by decreased metabolism or hypometabolism, which may lead to loss of specific neurons. These neurons have a high energy demand and a compromised glucose uptake or consumpation may lead to terminal neuronal fields and glial metabolism. Ketone bodies have also been found to have protective effects against cerebral A beta toxicity and cell damage in rat culture hippocampal neurons by promoting the actions of endogenous anti-inflammatory molecules.
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Could be soon possible to use these endemic VIRUSES TO EXTEND the LIFESPAN of humans?
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Could be possible to use endemic viruses to extend the lifespan of humans? | Recent experimentations
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Since the industrial revolution, the invention of antibiotics, and the discovery of micrograms scientists have been on their toes to extend the lifespan of human beings. Scientists and researchers throughout the world have been trying to find out how to stop aging effects. The invention of the electron microscope and extensive research studies such as the Human Genome Project in the last century paved the way for practical steps in lifespan extension. Researchers and scientists have successfully shown that telomerase reverse transcriptase (TERT) can be injected into cells of living mice through a viral vector. This will in turn make necessary genetic changes in the body cells and tissues. Ultimately this idea of life extension through gene therapies can become a reality from science fiction. So the whole idea revolves around viral vectors such as endemic viruses. Cytomegalovirus is one such choice for scientists. And by a viral vector means that a virus will be used to make necessary genetic changes in the human once the trials become successful. So one should ask the question: why are scientists using the Cytomegalovirus virus as a viral vector? The answer is that the human cytomegalovirus (CMV) is an endemic virus. Most of its effects on the adult human body are asymptomatic. It is because of its few properties that make this virus a suitable agent for vectors. Cytomegaloviruses can carry large genetic payloads and don’t overwrite the DNA of their host cells. In phase 1 of clinical trials in humans, it has successfully replaced target DNA. Telomeres are important sequences at both ends of human DNA in chromosomes. They protect DNA from getting broken or joining with other molecules. Telomeres decides the number of times our cells can divide. With aging telomeres lose their ability to divide and produce new healthy cells. This leads to tissue and organ atrophy. This is what we call the aging phenomena.
Luckily there is a solution to this problem as well. Stem cells produce an enzyme called Telomerase Reverse Transcriptase, simply TERT. TERT functions to restore lost telomeres on our chromosomes. In a successful trial mediated by viral vector Cytomegaloviruses, gene therapy has extended lifespan in mice. Based on this breakthrough scientists are now counting on injecting Telomerase Reverse Transcriptase enzymes into the DNA of Cytomegaloviruses. They further plan to infect a human subject with this endemic and harmless virus to restore aging cells and tissues in the human body. The final goal would be to achieve an extended lifespan for human beings by reproducing lost and aging cells, tissue, and organs of the human body. The good news is that phase of this experimental trial has been completed successfully on humans. There is hope for this research study. Hopefully, if trials are successful to the end, humans will be able to enjoy many more decades of healthy life. This will extend the average life expectancy across the globe.
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Luteolin neuroprotective effects | Luteolin and neuroinflammation
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Luteolin neuroprotective effects | Luteolin and neuroinflammation
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Luteolin is a natural flavone that is present in various plants such as celery, broccoli, and cabbages. It is known for its pharmacological activities including its anti-inflammatory, anti-viral, antioxidant, anti-allergy and anti-bacterial effects. Research suggests that luteolin exhibits neuroprotective effects by suppressing neuroinflammatory response in neurodegenerative diseases. Neuroinflammation refers to the inflammation of the neurons. Neuroinflammation is involved in most of the neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis and Huntington's disease. Luteolin has been shown to inhibit the production of pro-inflammatory cytokines such as Tumor Necrosis Factor alpha and cyclooxygenase 2. Tumor necrosis factor alpha or TNF alpha is a pro-inflammatory cytokine that plays a critical role in inflammatory disorders including neuroinflammation. In pathological conditions, TNF alpha is release in large amounts by microglia and astrocytes, which leads to the release of neuroinflammatory signaling involved in the pathogenesis of several neurological disorders, including alzheimer's disease and Parkinson's disease.
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How to raise NAD+ level without supplements | Things you can do FOR FREE to be biologically YOUNGER
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How to raise NAD+ level without supplements
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NAD+ is the essential coenzyme required for energy requirements in our body. It also helps other biological molecules in the body.Aging is associated with joint disorders, muscle wasting, low energy, and wrinkling of the skin. This is due also to the depleted coenzyme from the body.Research studies have shown that aging can be slowed down significantly. NAD is one of the best ingredients that is utilized to the fullest and gives maximum energy to the body. Depleted levels of NAD in the body are associated with susceptibility to infections, obesity, decreased metabolism, cardiovascular diseases, and even cancer in some cases. So to slow aging one must replenish NAD+ levels in the body. Some people take supplements to replace it but this approach is not the only one. It is also possible to generate NAD+ from natural sources. It can be increased by doing a lot of exercise, doing gym, staying out of sun rays, and diet modification. Natural NAD+ stores in the body depend also on what a person eats and what not. Since NAD is a coenzyme, it is derived from the Vitamin B complex group of vitamins. Therefore a person needs to consume diets that are rich in Vitamin B. Avocados, fish, nuts, and omega fatty acids are particularly important diets for the production of NAD levels in the body. Studies have shown that cow milk and tea also stimulate the production of NAD in the body naturally. People who are on a diet plan are fortunate to have low carbohydrates in their bodies. Low carbohydrate is linked with more protein. This causes ketosis. The Keto diet induces weight loss in the body. This causes the production of NAD in the body. Fasting is a natural way of production of NAD exponentially in the body. Fasting causes hypoglycemia. And hypoglycemia is a natural trigger of the body towards shock and it ramps up NAD production. Continuous or prolonged exposure to the sun is responsible for the active damage of skin cells. Here NAD plays a vital role in repairing these damaged cells. In other words, exposure to the sun damages cells, and NAD is depleted in the repairing process. So it is advised to stay away from the sun for prolonged exposure. Hence to prevent aging, and to conserve NAD stores in the body continuous exposure to the sun must be avoided. Consuming foods such as mushrooms, green vegetables, yeasts, and dairy milk are the natural boosters for NAD+ production in the body. Cutting down on alcohol is also linked with the ramp-up of NAD production in the body.We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to a professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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YOU HAVE TO ACTIVATE AMPK! What is AMPK and why people in longevity science speak so much about it
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What is AMPK and why people in longevity science speak so much about it
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AMP-activated protein kinase (AMPK) is a protein that is activated by exercise, fasting, and calorie restriction. It is an enzyme that regulates the metabolic pathways in the body. AMPK has been shown to have a positive effect on longevity and aging.AMPK activation leads to an increase in the production of ATP and a decrease in the production of glucose.AMPK activation also leads to an increase in autophagy, which is the process by which cells recycle their own components. This process helps cells maintain their health and function during periods of starvation or other low-energy conditions.The activation of AMPK has been shown to increase lonjévity in animals and humans. It also has been shown to have anti-aging effects on the brain and other organs.Activated AMPK acutely triggers the destruction of existing defective mitochondria via ULK1-dependent mitophagy and simultaneously triggers the biogenesis of new mitochondria via effects on PGC-1a dependent transcription.As far as it concerns the activation of AMPK with exercise, AMPK is activated in an intensity-dependent manner, such that its activation is usually observed acutely at exercise intensities above 60% of maximal aerobic capacity.AMPK can also be activated by some foods like blueberries, grapefruit and green tea.Multiple supplements play also a role in AMPK activation.For example, berberine significantly activates AMPK and mitigates the effects of high glucose.We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to your doctor or other professional before beginning any sort of supplementation or treatment. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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YOUR BODY CAN BE TRANSFORMED IF... DISCOVER NOW what happens to your body when you stop eating sugar
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What happens to your body when you stop eating sugar
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Sugar is an essential part of our daily diets. Most of the adult population of the world is highly addicted to sugar and sugar-related processed foods. This is because it is sweet to taste, easily accessible, and almost present in every food item. So the consumption of sugar has become a permanent lifestyle. But it has potential health hazards such as development of diabetes mellitus, cardiovascular disease, stroke, renal failure, and permanent blindness. A study showed that an adult American consumes 152 pounds of sugar weekly. This is beyond what health professionals consider a safe limit. Although consuming sugar is highly addictive it has plentiful benefits if a person stops eating sugary diets. Here are positive outcomes if a person stops consuming sugar more than its threshold.
Brain health is directly affected by the sugar level in your body. If you stop eating too much sugar, you'll become mentally smart, sharp, and active in your daily life activities. Cognition and long-term memory are improved with less sugar intake in our diets. Research has shown that higher fructose and glucose in blood lead to Insulin resistance. It affects cognition, and memory centers such as the frontal cortex and hippocampus in the brain. So tight control of sugar will reward you in the form of smartness and sharpness.
By consuming less sugar you are going to decrease your chance of getting diabetes in the early decades of your life. Diabetes mellitus is directly caused by eating too much sugar and sugar-related diets such as fizzy drinks, and sweets. Diabetes in turn will complicate your liver, kidney, heart, eyes, and brain. Therefore taking less sugar on the daily menu will reduce the risk of getting diabetes.
Another benefit of less consumption of sugar is control on your weight. You'll never gain too much weight or get obese if you don't eat too much sugar. Sugar contributes calories more than is required for our body. These calories go into adipose tissues such as belly, thigh, and buttock fats. This causes weight gain, and obesity. Similarly, sugar triggers the appetite center in the brain that keeps asking for more food despite stomach needs being fulfilled. So less consumption of sugar means less or no weight gain.
Eating too much sugar in the form of soft drinks will make you happy for a moment. But in the long run ingredients of such drinks are inflammatory in nature. Studies have linked too much sugar causing depression in adults. So for a brighter, happier, and longer life, one should avoid too much sugar in food choices.
Less intake of sugar will make your skin glow. Sugar-laden foods are the prime source of blemishes, acne, pimples, and other skin disorders such as rashes.
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Acarbose | better than Metformin for aging? | 30% lifespan extension in mice? | New longevity drug?
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Acarbose | better than Metformin for aging? | 30% lifespan extension in mice? | New longevity drug?
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Acarbose is a drug that was approved by the to treat type 2 diabetes. The drug works by slowing down the digestion of carbs in the intestines, which helps control blood sugar levels.
The drug was approved in 1997 and is still used today. It’s a type of alpha-glucosidase inhibitor, which means it slows down the digestion of carbs in the intestines.
Acarbose may also have an effect on aging.
In a study published in Cell Metabolism, researchers found that Acarbose could have the potential to extend the lifespan of mice.
The study showed that the mice given this drugs lived up to 30% longer than the control group of mice.
A 30% increase would be phenomenal if it could be reproduced in humans. Especially if you think that many studies say that even a cure for cancer would only make human lifespan 3% longer.
Another study published in Nature Medicine also found that Acarbose could have also the potential to control weight.
The study was conducted by scientists from Yale University. and it consisted of two phases. In the first phase, researchers fed mice a high-calorie diet and gave them either a placebo or an Acarbose pill every day for six months. The second phase consisted of feeding them a normal diet and giving them either a placebo or an Acarbose pill every day for four months. The findings revealed that the mice who were given the Acarbose pills during both phases were more likely to lose weight and keep it off than those given the placebo pills.
Other research also shows that acarbose increased the lifespan of mice from 10% to 20%. However, this effect is visible mostly in male mice.
Some researchers think that this drug could be used to help people live longer and healthier lives, and many studies are being done on this matter right now.
We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to your doctor or other professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Coenzyme Q10 and Alzheimer's disease
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Coenzyme Q10 and Alzheimer's disease
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Prediabetic symptoms
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Prediabetic symptoms
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Prediabetes is a condition of the human body before the full development of diabetes mellitus. In prediabetes blood, sugar level is greater than the normal. But it is less than the threshold to be called a confirmed case of Diabetes. Mostly prediabetic state leads to the development of type 2 diabetes mellitus. Younger adults and children are at risk of getting into chronic conditions of diabetes if they fail to notice symptoms of being prediabetic. In prediabetic states, our body starts developing initial symptoms of diabetes. So it is very necessary at this stage to diagnose prediabetic symptoms and stop their progression. Prediabetic states can be slowed or even stopped or reversed by modifying diets, lifestyle changes, and exercise. Maintaining weight and body mass index at an optimal level can make the symptoms at the prediabetic stage vanish away. Diet and lifestyle modification bring blood sugar levels to normal. In a prediabetic state, symptoms are usually less visible and difficult to detect. This is because a person's metabolic state is being shifted to the diabetic pattern. One of the most prominent symptoms is the darkening of the skin on the neck, armpits, and groin. Symptoms such as fatigue, increased thirst, blurred vision, tingling sensation in the feet, and frequent urination show that a person is now moving from prediabetes to type 2 diabetes. This is the stage where you should contact your health care provider or family physician. At this level doctors usually take a detailed history, do and a physical examination, and screen people for their blood sugar levels. In prediabetic states, fasting blood sugar is usually 120-140 milligrams per deciliter. And the body mass index is around 25. There is a definitive screening test for prediabetic people. This is called HbA1c. This test tells the estimated average blood sugar level of a person in the last 3-4 months and total glycemic control. 5-6 milligrams per deciliter is the prediabetic state. Whereas HbA1c greater than 6 or 6.5 shows a type 2 diabetic state in the body. Weight gain due to fat-containing foods, sedentary lifestyle, genetics, and age are the risk factors for shifting from a prediabetic state to type 2 diabetes. Cessation of smoking, getting rid of extra fat content, and doing mandatory daily exercises can help people who are at risk of developing a prediabetic state in their bodies.
We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to a professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Best foods to clean your liver | EAT some of them this week and START FEELING BETTER
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Best foods to clean your liver
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The liver is a vital organ of the human body. It acts as a powerhouse of the body as well. The liver plays a central role in most of the metabolic pathways taking place in the body. By acting on different vitamins and minerals it stores these components for future uses. The liver is the place where most of the toxins, medicines, and by-products are broken down. Catabolic and anabolic pathways are taking place in the liver. Breakdown of haemoglobin and other globulins is a function of the liver. Most of the food and blood before entering the general circulation is routed through the liver for cleansing activity. Therefore a healthy and fully functioning liver is important for the optimal health of a person. Certain foods keep the liver healthy and fit. Foods such as grapefruit, blueberries, cranberries, tea, and coffee are recommended to keep your liver healthy. Prickly pear, Beetroot juices, cruciferous vegetables, nuts, and olive oil are natural foods that have a cleansing action on our liver. Health professionals often recommend these foods to keep your liver healthy and clean. Olive oil is safe and healthy fat in every research study conducted on its uses. Olive oil has been seen in reducing the fat content in the arteries. Doing so improves blood flow in the blood vessels. It also optimizes liver enzymes. Olive oil reverses fatty liver disease. Fatty fish is a rich source of omega-3 fatty acids. These are known to detoxify the liver by removing extra fats from the liver. Omega 3 fatty reduces acute Inflammatory reactions in the liver. Nuts are richly supplied with vitamin E and other natural compounds. Studies have shown that nuts decrease the risk of non-alcoholic fatty liver disease. Cruciferous vegetables such as mustard green, broccoli, and Brussels sprouts are very rich in fiber content. These foods enhance liver enzyme activity. Beetroot juices contain antioxidants and nitrates. These possess anti-inflammatory properties in the liver. Overall beetroots reduce oxidative damage in the heart and liver. Prickly pear reduces Inflammatory reactions in the liver. Similarly, grapes have beneficial anti-inflammatory effects on the liver parenchyma. The above-discussed foods also detoxify the liver and remove toxins. Furthermore, is essential to take foods that have anti-inflammatory and antioxidant properties.
We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to your doctor or other professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Leaky Gut Syndrome | Here is how to discover if you have it
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Leaky Gut Syndrome | Here is how to discover if you have it
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Do you get daily tummy aches, fatigue and eczema, or hives all over your body? It is possible that you may have Leaky Gut Syndrome and not even be aware of it. The reason is simple: it can show itself in many different ways.
Diseases that can cause leaky gut include coeliac disease, diabetes, and irritable bowel syndrome, among many others.
First of all, we need to know that the intestine is naturally permeable. That is, it allows very small molecules to pass through so that the body can absorb important nutrients. In fact, regulating intestinal permeability is one of the basic functions of the cells found in the intestinal wall.
However, Leaky Gut Syndrome occurs when the intestinal walls become too inflamed. As a result, openings between the epithelial cells in the intestinal barrier, called "tight junctions", allow toxins, microbes, undigested food particles, and others to pass into the bloodstream. And this makes it possible for them to circulate through our bodies.
In this situation, our immune system identifies these "invaders" as pathogens and attacks them.
Among the most common symptoms that people suffering from Leaky Gut Syndrome may have 1. Food intolerances, gas, diarrhea, and constipation; 2. Headache; 3. Tiredness; 4. Joint pain; 5. Dermatitis, eczema, and seasonal allergies.
There is a test to indirectly evaluate whether there is an alteration in the absorption of the intestinal wall, although it is not yet used to give a clear diagnosis or treatment.
It is a test that measures the amount of two molecules that we can eliminate in the urine, after being administered orally. One larger called lactulose and one smaller called mannitol. If more lactulose than expected appears in the urine, it means that there is an increase in intestinal permeability, as it has been able to pass into the bloodstream. On the other hand, if hardly any mannitol is detected, it may be a cause of malabsorption or decreased permeability, and lead to malnutrition and developmental problems.
We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to your doctor or other professional before beginning any sort of supplementation or treatments. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Supplementation with Chaga Mushrooms
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Supplementation with Chaga Mushrooms
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Every now and then, a new food from other cultures goes viral thanks to social media and corporate marketing. Do acai, maca powder, chia seeds and carob sound familiar? Well, this time it is the turn of the Chaga Mushroom, a parasitic fungus that grows in cold regions, more specifically in Canada and Eurasia, and has been used for thousands of years as a home remedy in Russia and China.
This fungus, which is also known as "the pearl of the North", has now reached the United States and Europe, where many are already talking about its many health benefits. It is said to have antioxidant properties that help prevent or treat some types of cancer, reduce cholesterol, help with pancreatitis, lower blood pressure, lower blood sugar levels and even strengthen the immune system.
It's a marvel!
The most common way to consume the Chaga mushroom is by infusion. In other words, the natural mushroom needs to be dehydrated and then broken into small pieces to be infused. The liquid will be similar to coffee, and will contain the active ingredients of the fungus.
But, nowadays, it can be found in capsules or pulverized extract that can be used to prepare drinks together with spices such as ginger, turmeric, and cinnamon, or mixed with chocolate, milk, tea, ice cream, and milkshakes. Chaga elixirs are available from shops such as herbalists for sublingual application.
However, as with any medicine, whether natural or not, there are situations in which care should be taken with its consumption. In this case, it should not be taken if you are on medication for autoimmune diseases, or if you are taking insulin, anticoagulants, and antiplatelet drugs. Nor if you have been diagnosed with candida in your body or if you have problems with itchy or dry mucous membranes, gas, and irritable bowel syndrome.
We would like to hear about your own experience with this topic. Leave a comment. Lastly, remember that it is important to talk to your doctor or other professional before beginning any sort of supplementation or treatment. Feel free to contact us if you want us to give you the contact information of professionals who work with our network.
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Psyllium husk
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Psyllium husk
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Psyllium, also known as ispaghula, is a fiber that derived from the husks of seeds of a plant that has a high water-binding capacity. Psyllium has been used as a treatment for constipation, and irritable bowel syndrome. Recently, it as been recognized for its ability to lower high low density lipoprotein or LDL cholesterol levels. Hypercholesterolemia is a lipid disorder characterized by elevated levels of LDL in the blood. Hypercholesterolemia is a major risk factor for coronary heart disease and lowering LDL levels through diet is an initial therapeutic approach. In a clinical study, the long term effectiveness of psyllium husk fiber as an adjunct to diet in the treatment of persons with hypercholesterolemia has been evaluated. Men and women, aged 21 to 70 years, were recruited for the study. Subjects were randomly divided into psyllium and placebo group. It has been found that 5 point 1 grams of psyllium twice daily reduces serum total and LDL cholesterol concentrations in men and women with primary hypercholesterolemia.
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Topic related to: LONGEVITY, HEALTH, IMMUNITY, INFLAMMATION, ANTIAGING, LIFESPAN, Mitochondria, HEALING, SUPPLEMENTS, HEALTHY LIFE, IMMUNE SYSTEM, LONGEVITY PROTOCOL.
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