Aldol Addition Reactions with Lithium & Proline (IOC 21)

Like and subscribe. This is an archive channel, i'm not the owner of the content, check the link in the end. *Disclaimer* LDA can also afford E-enolates, and usually a mixture is obtained; if an ester or an amide is used instead of a ketone, the selectivity can change! Depending on the ketone that is used, the selectivity can also reverse.

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Links to articles discussed in this episode:
first lithium aldol - https://doi.org/10.1039/D0SC06223E
second lithium aldol - https://doi.org/10.1002/chem.201502754
Ben List - https://doi.org/10.1021/ja994280y
Nobel Prize - https://www.nobelprize.org/prizes/chemistry/2021/list/lecture/
proline aldol example - https://doi.org/10.1126/science.abb3231
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I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people!

Recommended Texts:
J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations)
T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016.
LibreTexts:
https://chem.libretexts.org/Bookshelves/Organic_Chemistry
https://rumblevideoarchive.wordpress.com/