AlchePharma

The current study demonstrated that a 14-day intake of 25 g of freeze-dried WBs, supplying 375 mg of anthocyanins and approximately 1 cup of fresh fruit equivalent, significantly increased FAT-ox rates, decreased CHO-ox rates, and led to lower blood lactate values without changes in glycerol and FA concentrations during 40 min of cycling at 65% of vo2peak in endurance-trained males. These findings may have potential effects on endurance exercise performance. #blueberries #lactate #metabolism Pilolla KD, Armendariz J, Burrus BM, Baston DS, McCarthy KA, Bloedon TK. Effects of Wild Blueberries on Fat Oxidation Rates in Aerobically Trained Males. Nutrients. 2023; 15(6):1339. https://doi.org/10.3390/nu15061339 Anthocyanins, polyphenols, wild blueberry, fatty acid oxidation, lipolysis, exercise, endurance, carbohydrates, glycogen sparing, blueberries. Blueberry, metabolism, FAT-ox, CHO-ox

In conclusion, the results of this study indicated that BA supplementation enhanced cognitive performance in older adults whose baseline cognitive levels were borderline to below normal. In addition, taking BA supplementation was able to reduce symptoms of depression. #betaalanine #depression #brainfunctions Ostfeld I, Ben-Zeev T, Zamir A, Levi C, Gepner Y, Springer S, Hoffman JR. Role of β-Alanine Supplementation on Cognitive Function, Mood, and Physical Function in Older Adults; Double-Blind Randomized Controlled Study. Nutrients. 2023; 15(4):923. https://doi.org/10.3390/nu15040923 Beta-alanine, geriatric depression, cognitive, Montreal cognitive scale, neuroinflammation, older, senior citizen, amino acid, mood, stress, cognitive function, improve, feel better, symptoms, supplementation, cognitive decline, enhanced cognitive performance, Moca, GDS

The Relationship between Mushroom Intake and Cognitive Performance: An Epidemiological Study in the European Investigation of Cancer—Norfolk Cohort (EPIC-Norfolk) A huge study in the UK followed thousands of people for years, uncovering a delicious secret: eating just one mushroom portion a week (think a small handful) was linked to sharper memory, faster thinking, and better mental control. This brain boost held strong even when considering other healthy habits, hinting that mushrooms might be a hidden weapon against mind fog and even low mood. While more research is needed, reach for those earthy fungi - your brain might just thank you! #MushroomPower #MindFood #EatYourWayToSmarter Cha S, Bell L, Williams CM. The Relationship between Mushroom Intake and Cognitive Performance: An Epidemiological Study in the European Investigation of Cancer—Norfolk Cohort (EPIC-Norfolk). Nutrients. 2024; 16(3):353. https://doi.org/10.3390/nu16030353 mushroom intake, cognitive performance, memory, dementia, depression, EPIC-Norfolk study, aging, brain health, superfood, dose-dependent, executive function, processing speed, fruit and vegetable intake, confounding factors, randomized controlled trials

PBM therapy has demonstrated efficacy in a broad range of neurocognitive and musculoskeletal diseases such as Parkinson's disease, depression, age-related dry macular degeneration, chronic wounds, arthritis, knee osteoarthritis, tendinopathy, and oral mucositis among many others #Photobiomodulation #heartdisease #850nm Syed, SB, Ahmet, I, Chakir, K, Morrell, CH, Arany, PR, Lakatta, EG. Photobiomodulation therapy mitigates cardiovascular aging and improves survival. Lasers Surg Med. 2023; 55: 278– 293. https://doi.org/10.1002/lsm.23644 Photobiomodulation, heart disease, coronary disease, healing, near infrared light, 850 nm, PBM, TGF, nonvisual phototransduction pathways, transforming growth factor beta , light therapy, Parkinson's disease, depression, age-related dry macular degeneration, chronic wounds, arthritis, knee osteoarthritis, tendinopathy,

Combat athletes, facing explosive bursts and grueling rounds, might find a friend in β-alanine. This amino acid, not a direct performance booster, fuels carnosine, a muscle buffer that fights fatigue. Studies suggest 4-6 grams daily for 4 weeks can improve performance in combat-like bursts (60-240 seconds), potentially boosting strength, power, work capacity, and even recovery. While more research is needed, β-alanine, timed with meals, could be a safe weapon in a combat athlete's arsenal, helping them push their limits and dominate the ring. #betaalanine #fightfatigue #CarnosinePower Fiandor, E. M., García, J. F., Busto, N., & Roche, E. (2023). β-Alanine Supplementation in Combat Sports: Evaluation of Sports Performance, Perception, and Anthropometric Parameters and Biochemical Markers—A Systematic Review of Clinical Trials. Nutrients, 15(17), 3755. https://doi.org/10.3390/nu15173755 beta-alanine, combat sports, fatigue reduction, performance enhancement, carnosine, muscle buffer, strength, power, work capacity, recovery, combat athletes, amino acid, supplement, safety, dosage, timing, research, studies, benefits, drawbacks, effectiveness, scientific evidence, #betaalanine #fightfatigue #CarnosinePower

There was a statistically significant (p=.039) difference in the participants' mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms. #agereversal #methylationdiet #epinutrients Fitzgerald KN, Campbell T, Makarem S, Hodges R. Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series. Aging (Albany NY). 2023 Mar 22; 15:1833-1839 . https://doi.org/10.18632/aging.204602 DNA methylation, age reversal, biological age, health span, life span, longevity, polyphenolic modulators of DNA methyl transferase, ten-eleven translocation (TET) demethylase cofactors, DMNT, a methylation-supportive diet, epi nutrients, curcumin, epigallocatechin gallate (EGCG), rosmarinic acid, quercetin, luteolin

Researchers gave breast cancer patients an extract from the Boswellia tree (aka frankincense) daily before surgery. Comparing tumor activity before and after, they found that the extract significantly slowed the tumors' growth, suggesting its potential as a natural anti-cancer treatment. This is promising early evidence, but further research is needed to confirm its long-term effects and potential side effects. #Boswellia #Frankincense #cancer Valente, I.V.B., Garcia, D., Abbott, A. et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat (2024). https://doi.org/10.1007/s10549-023-07215-4 Boswellia, frankincense, breast cancer, tumor growth, clinical trial, MUSC Hollings Cancer Center, natural cancer treatment, alternative medicine, cancer research, breakthrough, promising results, early study, reduce tumor size, slow cancer growth, inhibit cancer cells, proliferation, apoptosis, safe and well-tolerated, Phase Ia window of opportunity trial, oral administration, 2400mg daily, human study, in vivo, in vitro

In summary, this RCT, evaluating the functionality of daily consumption of flaxseed oil containing 2.2 g of ALA, improved verbal fluency in healthy individuals aged between 65 to 80 years, with no abnormalities in cognitive function, despite declines with age. Since the improvement in verbal fluency is significant in cognitive health, as it is one of the factors of Alzheimer’s disease progress [37], further validation studies, with a focus on ALA’s impact on verbal fluency and executive function, are needed to extend the obtained evidence in this study to older adults. #flaxseedoil l #verbalfluency #executivefunction Ogawa, T., Sawane, K., Ookoshi, K., & Kawashima, R. (2023). Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults. Nutrients, 15(6), 1499. https://doi.org/10.3390/nu15061499 Ala, cognitive function, age, flax seed oil, executive function, Alzheimer’s , verbal fluency, dha, alpha linolenic acid, docosahexaenoic acid

In summary, research suggests that while young and healthy individuals may have adequate immune defenses against upper respiratory tract infections (URTIs), supplementing with COL can provide valuable support in protecting those who are at a higher risk of infection due to exposure to a heavy workload and increased contact with infectious agents. #colostrum #infections #immune Stachowska, E., Grochans, E., Bühner, L., & Hałasa, M. (2023). Moderate Dose Bovine Colostrum Supplementation in Prevention of Upper Respiratory Tract Infections in Medical University Students: A Randomized, Triple Blind, Placebo-Controlled Trial. Nutrients, 15(8), 1925. https://doi.org/10.3390/nu15081925 Colostrum, bovine colostrum, immune, respiratory tract infection, URTI, oral colostrum

A single dose of mangiferin-quercetin, taken one hour before exercise, significantly improved participants' performance in a demanding physical test. They completed circuits faster and reported feeling less exertion compared to those given a placebo. This suggests the supplement could enhance overall exercise performance by boosting endurance and reducing fatigue. Further studies are needed to confirm these findings in different exercise types and populations. #NaturalEnergyFuel #BreakThroughFatigue #alchepharma Alchepharma,Ralph Turchiano,citation,research,study,Mangiferin,Quercetin,mango,Mangifera indica,exercise performance,single dose,muscle oxygen extraction,basketball simulation,circuit time,perceived exertion,endurance,fatigue,athletes,natural supplement,pre-workout,recovery,brain oxygenation,oxygen extraction,high-intensity exercise,non-athletes,double-blind study,randomized controlled trial,sports performance,athletic performance,exercise science Bourdas, D. I., Travlos, A. K., Souglis, A., Stavropoulou, G., Zacharakis, E., Gofas, D. C., & Bakirtzoglou, P. (2024). Effects of a Singular Dose of Mangiferin–Quercetin Supplementation on Basketball Performance: A Double-Blind Crossover Study of High-Level Male Players. Nutrients, 16(1), 170. https://doi.org/10.3390/nu16010170

"Remarkably, the cognitive scores increased to levels similar to undergraduates taking the same cognitive tests for the first time," Wu said. "Our finding of continuous cognitive growth in older adulthood is unique because most studies show only maintenance of cognitive abilities or cognitive decline over time." #brain #cognitive #aging Leah Ferguson, Debaleena Sain, Esra Kürüm, Carla M. Strickland-Hughes, George W. Rebok, Rachel Wu. One-year cognitive outcomes from a multiple real-world skill learning intervention with older adults. Aging & Mental Health, 2023; 1 DOI: 10.1080/13607863.2023.2197847 Musical expertise makes older adults better listeners by keeping brain young "Playing music makes older adults better listeners by preserving youthful neural patterns as well as recruiting additional compensatory brain regions. Our study provides empirical evidence to support that playing music keeps your brain sharp, young, and focused,” said Dr. DU, corresponding author of this study. Zhang, L., Wang, X., Alain, C., & Du, Y. (2023). Successful aging of musicians: Preservation of sensorimotor regions aids audiovisual speech-in-noise perception. Science Advances. https://doi.org/adg7056 Cognition, learning, DMN, frontoparietal, cognitive control, working memory, episodic memory, default mode network, continuous cognitive growth, successful aging, youthful brain, dementia, Alzheimer's, speech processing, reverse aging brain, improved brain function, older learners

The scientists think that the ethanol vapor must increase ethanol concentrations in the fluid to 20% to successfully treat the infection. This concentration is not toxic to lung cells the scientists created in the lab to mimic human cells. At body temperature, 20% ethanol can not only inactivate the influenza A virus outside of the cells in one minute, but also stop the virus from replicating inside these cells. #influenza #ethanol #virus Tamai, M., Taba, S., Mise, T., Yamashita, M., Ishikawa, H., & Shintake, T. Effect of Ethanol Vapor Inhalation Treatment on Lethal Respiratory Viral Infection With Influenza A. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiad089 Influenza A virus, ethanol, Influenza , Avian Flu, Sars COV 2, coronavirus, inhalation, enveloped virus, etoh vapor, progeny virus, respiratory infections, severe acute respiratory syndrome coronavirus 2

This study showed that the ingestion of adenosine-containing mushrooms and vegetables may effectively increase testicular testosterone production. We conclude that mushrooms with a relatively high adenosine content, such as enokitake, may be useful against aging and fatigue. #enokitake #testosterone #leydig Iguchi, K., Nagashima, K., Mochizuki, J., Yamamoto, H., Unno, K., & Miyoshi, N. (2023). Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models. Nutrients, 15(9), 2142. https://doi.org/10.3390/nu15092142 Adenosine, enokitake mushroom, enoki, testosterone, male menopause, mushrooms, Leydig cells, polyphenols, Flammulina velutipes. Golden needle, winter mushroom, fatigue, anti-aging, post cycle

A 12-week study found that daily beetroot juice supplementation significantly lowered blood pressure and improved exercise capacity in people with chronic obstructive pulmonary disease (COPD). This suggests that beetroot, rich in dietary nitrates, could be a safe and well-tolerated alternative or complement to conventional antihypertensive medications for COPD patients. While further research is needed to confirm long-term benefits and potential interactions with other medications, the study offers encouraging evidence for the potential of beetroot juice as a natural approach to managing COPD symptoms. #COPDBreakthrough #NaturalReliefCOPD #AlchePharma Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC a randomised controlled trialAli M Alasmari, Abdullah S Alsulayyim, Saeed M Alghamdi, Keir E J Philip, Sara C Buttery, Winston A S Banya, Michael L Polkey, Paul C Armstrong, M J Rickman, Timothy D Warner, J A Mitchell, Nicholas S Hopkinson European Respiratory Journal Jan 2023, 2202353; DOI: 10.1183/13993003.02353-2022 Alchepharma,Ralph Turchiano,citation,research,study,beetroot juice and COPD,beetroot juice supplement and COPD,dietary nitrate and COPD,nitric oxide and COPD,blood pressure and COPD,exercise capacity and COPD,alternative treatments for COPD,natural remedies for COPD,ON-BC trial,European Respiratory Journal 2023,Ali M Alasmari et al.,400mg nitrate beetroot juice,6-minute walk distance in COPD,systolic blood pressure in COPD,safety of beetroot juice in COPD

The results of this study provide proof-of-concept that GlyNAC supplementation improves age-associated cognitive decline and supports brain health in aging by improving/correcting brain GSH deficiency, elevated OxS, mitochondrial dysfunction, abnormal mitophagy and autophagy, inflammation, impaired glucose transport/uptake, elevated genomic damage, and reversing the decline in brain neurotrophic growth factors. GlyNAC could be a simple and effective nutritional supplement to support brain health and cognitive function in aging, and warrants additional investigation. #glynac #brainrespiration #cognition Kumar, P., Osahon, O. W., & Sekhar, R. V. (2023). GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging. Antioxidants, 12(5), 1042. https://doi.org/10.3390/antiox12051042 Glynac, glycine, N-Acetylcysteine, correction, GSH Synthesis , cognitive improvement, brain health, GSH, OxS, mitochondrial energetics, autophagy/mitophagy, glucose transporters, inflammation, genomic damage, neurotrophic factors

The manipulation of the timing and dose of kiwifruit may have applications in terms of sleep and recovery (e.g., antioxidant consumption in relation to training) in athletes that warrant further investigation. The results presented suggest a potential role for kiwifruit consumption in sleep promotion and recovery protocols for elite athletes. Consuming 2 kiwifruit 1 h before bed is a practical wholefood-based intervention that can easily be implemented in real-world settings. Kiwifruit is available in wholefood form, but it is also consumed in various processed forms, e.g., drinks, sweets, lyophilised products (i.e., freeze dried), dehydrated products and juices [64]. Further research is warranted to develop protocols and/or products designed specifically to promote sleep and/or recovery in elite athletes. #kiwi #exercise #sleep Doherty, R., Madigan, S., Nevill, A., Warrington, G., & Ellis, J. G. (2023). The Impact of Kiwifruit Consumption on the Sleep and Recovery of Elite Athletes. Nutrients, 15(10), 2274. https://doi.org/10.3390/nu15102274 Kiwi, kiwifruit, sleep, Actinidia Deliciosa, training, recovery, disturbed sleep, anxiety, vitamin c, serotonin, melatonin, folate, Regulatory, Satisfaction, Alertness, Timing, Efficiency, athletes, exercise, overtraining, restful sleep, protocol, wholefood, unexplained underperformance syndrome, uup, overtraining, RU-SATED

A new study suggests that simply swapping one serving of starchy carbohydrates for vegetables daily can significantly improve fatty liver disease (NAFLD), even in advanced stages. Researchers found that after just three months, this minor dietary change led to reductions in liver fibrosis, inflammation, and other NAFLD markers. The key seems to be the type of vegetables chosen: the study focused on four cruciferous varieties (mizuna, chicory, kale, and Chinese mustard) rich in glucobrassicin-derived compounds with antioxidant and anti-fatty liver properties. This easy-to-implement dietary tweak could offer a promising first step for managing and potentially reversing NAFLD. #NAFLD #diet #fattyliver De Nucci S, Rinaldi R, Di Chito M, Donghia R, Giannuzzi V, Shahini E, Cozzolongo R, Pesole PL, Coletta S, De Pergola G, et al. The Replacement of Only One Portion of Starchy Carbohydrates with Green Leafy Vegetables Regresses Mid and Advanced Stages of NAFLD: Results from a Prospective Pilot Study. Nutrients. 2023; 15(10):2289. https://doi.org/10.3390/nu15102289 NAFLD,fatty liver diet,natural remedies,reversal,diet changes,liver health,cruciferous veggies,glucobrassicin,one serving change,mid advanced NAFLD,pilot study,replace carbs greens,leafy greens fatty liver,3 month diet challenge,fibrosis reduction swaps,manage reverse

The study found substantial differences after 3 months, with participants losing on average 10.4cm off their waist circumference (from an average 98.4cm at the start of the study to 88cm) and 4% of total body fat (from average 28.2% to 24.3%). #auricular #ear #weightloss Poster presentation PO4.085 at the European Congress on Obesity (ECO) Dublin, Ireland (17-20 May 2023) Auricular, ear, acupuncture, acupressure, appetite, metabolism, weight loss, bmi, hunger, digestion, vagus nerve, beads, acupoint stimulation

The MIT group is not the first to show that gamma frequency tactile stimulation can affect brain activity and improve motor function, but they are the first to show that the stimulation can also reduce levels of the hallmark Alzheimer’s protein phosphorylated tau, keep neurons from dying or losing their synapse circuit connections, and reduce neural DNA damage. #Vibrotactile #Alzheimers #tau Suk, H., Buie, N., Xu, G., Banerjee, A., Boyden, E. S., & Tsai, L. (2023). Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function. Frontiers in Aging Neuroscience, 15. https://doi.org/10.3389/fnagi.2023.1129510 Neurodegenerative, dementia, Alzheimer’s, tau, somatosensory cortex, primary motor cortex, motor function, gamma frequency, 40hz, Vibrotactile stimulation, GENUS, for Gamma Entrainment Using Sensory stimuli, als, ftd, Pick disease, progressive supranuclear palsy, tauopathies, frontotemporal dementia, Parkinson’s disease

Other subclasses showed no association (P values range: 0.12–0.99), but every 10 mg/d of higher quercetin intake was associated with 35% lower odds of frailty onset (OR: 0.65; 95% CI: 0.48–0.88). #Frailty #quercetin #flavonols Oei, S., Millar, C. L., Nguyen Lily, T. N., Mukamal, K. J., Kiel, D. P., Lipsitz, L. A., Hannan, M. T., & Sahni, S. (2023). Higher intake of dietary flavonols, specifically dietary quercetin, is associated with lower odds of frailty onset over 12 years of follow-up among adults in the Framingham Heart Study. The American Journal of Clinical Nutrition. https://doi.org/10.1016/j.ajcnut.2023.04.013 Frailty, falling, weakness, quercetin, flavonols, osteoporosis, sarcopenia. Kaempferol, myricetin, aging, elderly, fisetin, strength, balance

The researchers found that taurine suppressed age-associated weight gain in female mice (even in “menopausal” mice), increased energy expenditure, increased bone mass, improved muscle endurance and strength, reduced depression-like and anxious behaviors, reduced insulin resistance, and promoted a younger-looking immune system, among other benefits. “Not only did we find that the animals lived longer, we also found that they’re living healthier lives,” Yadav says. #taurine #aging #health Singh, P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M. A., Chamoli, M., Shi, S. L., Bastos, B. L., Nair, T., Riermeier, A., Vayndorf, E. M., Wu, J. Z., Nilakhe, A., Nguyen, C. Q., Muir, M., Kiflezghi, M. G., Foulger, A., Junker, A., Devine, J., . . . Yadav, V. K. (2023). Taurine deficiency as a driver of aging. Science. https://doi.org/abn9257 Taurine, serum concentration, aging, anti-aging, disease, hypotaurine, type 2 diabetes, wbc, insulin, bmi. Metabolism, waist circumference, N-acetyl taurine, exercise, hemoglobin, platelets, circulating taurine, age-associated pathologies, lower glucose

“In a long series of studies, we have shown that increasing amounts of lutein and zeaxanthin in the retina and brain decrease glare disability and discomfort and improve chromatic contrast and visual-motor reaction time, and supplementing these compounds facilitates executive functions like problem-solving and memory. All of these tasks are particularly important for athletes,” #vision #lutein #zeaxanthin Harth, Jacob B.1; Renzi-Hammond, Lisa M.1,2; Hammond, Billy R. Jr2. A Dietary Strategy for Optimizing the Visual Range of Athletes. Exercise and Sport Sciences Reviews 51(3):p 103-108, July 2023. | DOI: 10.1249/JES.0000000000000318 Visual range, distance vision, macular pigment optical density . reaction speed, yellow pigment , blue light, contrast, visual-motor function, executive cognition, glare disability, photo stress, chromatic contrast, athletic performance, coincidence anticipation ability, carotenoid

Most of the world's population either chronically suffers from plaque and dental cavities or will develop them at some point in their lives. Toothpastes, mouthwashes, and regular checkups do their part, but more could always be done. Ben-Gurion University of the Negev scientists and their colleagues at Sichuan University and the National University of Singapore have discovered that 3,3′-Diindolylmethane (DIM), a naturally occurring molecule also known as bisindole, reduces the biofilms that produce plaque and cavities by 90%. The molecule is also found to have anti-carcinogenic properties. #DIM #Cavities #plaque Baruch Y, Golberg K, Sun Q, Yew-Hoong Gin K, Marks RS, Kushmaro A. 3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm. Antibiotics. 2023; 12(6):1017. https://doi.org/10.3390/antibiotics12061017 DIM, Cavity Fighter, S.Mutans, Oral Health, Oral Microbiome, Diindolylmethane, biofilm, teeth, tooth, cavity preventer, anti-plaque, healthy mouth, natural anti-biofilm agents, extracellular polymeric substance, toothpaste, mouthwash

Both clinical and pre-clinical animal studies have supported the therapeutic usefulness of MSM for joint diseases such as OA; however, there is no direct evidence to support prophylactic use for joint diseases or use to maintain the normal condition of joints in a healthy population. In the present study, we conducted a randomized, double-blind, placebo-controlled trial of oral consumption of MSM on mild pain of the knee joint in healthy participants. #MSM #methylsulfonylmethane #kneepain Toguchi, A., Noguchi, N., Kanno, T., & Yamada, A. (2023). Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 15(13), 2995. https://doi.org/10.3390/nu15132995 Knee pain, KOA, MSM, Methylsulfonylmethane, osteoarthritis, arthritis, mild pain, inflammation, anti-inflammatory, stiffness, knee stiffness, sulfur

This research delves into "oxymel", an ancient honey-vinegar mix, for its potential to combat infections. Vinegar, while effective alone, may harbor additional antibacterial powers beyond its acetic acid. When paired with manuka honey, vinegar showed a promising "synergy" against stubborn bacterial colonies. Pomegranate vinegar emerged as a champion for further study. Overall, this study rekindles interest in traditional remedies like oxymel, showcasing their potential for modern medicine.