Resident Evil 2 - Claire B

One of the best things about RE2 was the fact that once you beat the game as one character, you could start another game as the other to fill out the story and get an added challenge in the form of the Neo Tyrant that appears throughout the game.

To me, the Leon A/Claire B scenarios were the easier of the possible combinations, mainly because you didn't need to worry too much about Sherry in Claire's B scenario.