Simple New Strategy Improves Safety and Precision of CRISPR Gene Editing

KAUST researchers have improved CRISPR gene editing safety by reducing harmful DNA deletions and enhancing repair mechanisms, advancing towards safer genetic treatments.
A simple and robust strategy developed by KAUST scientists could help to improve the safety and accuracy of CRISPR gene editing, a tool that is already approved for clinical use for the treatment of inherited blood disorders.

This approach tackles a critical issue with CRISPR technology: the act of slicing the genome at specific points and then rejoining it, which inherently risks damaging the DNA in a manner that might cause large-scale and unpredictable disruptions.