Ep 044 - The Facts: Obesity & Ozempic

We've all seen headlines about Ozempic, Wegovy, Mounjaro and Zepbound. These GLP-1 Agonist injections have become the most popular new pharmaceutical in decades. They have tremendous potential to radically change the lives of millions of people, but they aren't without their risks.

For the next two episodes, the boys are taking a closer look at what these drugs do and how they do it. To do that, we've got to have a clear idea of the problems they're looking to address: Type 2 Diabetes and Obesity as a disease state.

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Generation Health is a weekly podcast discussing cutting edge research and time tested best practices to help you live better, longer. Dante DiMatteo (PharmD, CSCS) is the second generation in a family dedicated to helping educate listeners so they can make informed decisions about their own health. Incorporating his extensive knowledge in pharmaceuticals, nutrition, exercise, and supplementation, he loves sharing his wisdom with anyone looking to improve their life!

CHAPTERS:
00:21 - Show Intro
03:12 - What is digestion?
06:04 - How does insulin work?
07:41 - Other hormones that aid in digestion
11:10 - What is GLP-1?
15:07 - Diabetes Basics
16:51 - How does obesity factor in?
18:25 - Additional points on GLP-1
21:18 - Obesity as a disease state
29:58 - What are GLP-1Agonists?
36:22 - GLP-1 + GIP Agonists
40:04 - Who are good candidates for these drugs?
42:29 - BMI as a tool
45:05 - How effective are these drugs?
51:05 - What are the downsides?
55:46 - Show Outro

SHOW NOTES:
1) Digestion (NIH) - http://tinyurl.com/2fspkea8
2) Insulin (NIH) - http://tinyurl.com/4a5c8akw
3) Glucagon (NIH) - http://tinyurl.com/5bhuv7s5
4) Amylin (MDPI) - http://tinyurl.com/4wv9wkp5
5) GLP-1 (NIH) - http://tinyurl.com/vw74ktrv
6) GIP (NIH) - http://tinyurl.com/2u9xp4m7
7) OZEMPIC (semaglutide) (package insert) - http://tinyurl.com/bdzbtvk9
8) Obesity (eClinicalMedicine) - http://tinyurl.com/hd5yr3jy
9) Obesity (NIH) - http://tinyurl.com/bdhbtn8v
10) Obesity (MDPI) - http://tinyurl.com/2e24nktb

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