Which Neurotoxin is the Worst?

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In this video, we explore several nerve-racking chemicals and discuss the biomechanics of nerves. I used to be a mouthpipetter like you, until I took a poisoned arrow in the knee.

A huge thanks to @reformlabs1050 and @ToAldous – I also want to thank Ballerene from the Discord for early research.

Writer/Producer: That Chemist
Editor/Animator: Reform Labs
Researcher/Production Assistant: Aldous

Support the Channel on Patreon - https://www.patreon.com/thatchemist

Join the Community Discord! - https://discord.gg/thatchemist
Second Discord link if the first one is borked - https://discord.gg/QWNPETtPcZ
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References:

Nerve Agent Tierlist - https://www.youtube.com/watch?v=5IFsaBBav78

neuron count in different species - https://doi.org/10.1073/PNAS.1201895109/
Nerves send signals - https://doi.org/10.1038/nn.4157.
Neurotransmitters - https://mind.ilstu.edu/curriculum/neurons_intro/neurons_intro.html
Synaptic Transmission - https://psych.athabascau.ca/html/Psych402/Biotutorials/animations/synapse.shtml
Neurotransmitter reuptake - https://doi.org/10.1101/CSHPERSPECT.A005595.
Hormones, Peptides, and Neurotransmitters and Their Role in Obesity - https://doi.org/10.1177/1559827617716376.
Melatonin - https://doi.org/10.3390/BRAINSCI9100285.
The Role of Brain Gaseous Neurotransmitters in Anxiety - https://doi.org/10.1007/S43440-021-00242-2.
Reactive Oxygen Species - https://doi.org/10.3389/FCELL.2021.628157/BIBTEX.
Alcohol, Oxidative Stress, and Free Radical Damage - https://doi.org/10.1079/pns2006496.
Toxicity of organomercury compounds - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183295/
Tetrodotoxin - https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html
BOTULINUM TOXIN - https://doi.org/10.4103/0019-5154.60343.
Tetraethylammonium - https://doi.org/10.1016/B978-0-12-801238-3.97466-X.
Toxiferine - https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/toxiferine
N-Hexane - https://doi.org/10.1136/jnnp.50.3.269.
MPP+ - https://www.sciencedirect.com/topics/medicine-and-dentistry/mpp
Epa, U.; of Water, O. Health Effects Support Document for the Cyanobacterial Toxin Anatoxin-A Office of Water Mail Code 4304T United States Environmental Protection Agency. 2015.
Elucidating the Neurotoxicity of the Star Fruit - https://doi.org/10.1002/ANIE.201305382.
Tubocurarine Chloride - https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/tubocurarine-chloride
The Phycotoxin Domoic Acid as a Potential Factor for Oxidative Alterations Enhanced by Climate - https://doi.org/10.3389/FPLS.2020.576971/BIBTEX.
Strychnine - https://www.sciencedirect.com/topics/medicine-and-dentistry/strychnine
Tetraethyllead - http://dx.doi.org/10.1136/oem.16.3.191
https://link.springer.com/article/10.1007/s13181-010-0034-5
https://doi.org/10.2131/jts.15.SupplementIV_125
Chlorpyrifos - https://www.epa.gov/ingredients-used-pesticide-products/chlorpyrifos
Tetramethylenedisulfotetramine -https://doi.org/10.1073/PNAS.1407379111/SUPPL_FILE/PNAS.1407379111.SAPP.PDF.
Structure-Toxicity Relationships of 1-Substituted-4-Alkyl-2,6,7-Trioxabicyclo[2.2.2.]Octanes - https://doi.org/10.1016/0041-008X(79)90323-5.
Neosaxitoxin - https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/neosaxitoxin
Carbon Disulfide - https://pubmed.ncbi.nlm.nih.gov/23331301/
https://pubmed.ncbi.nlm.nih.gov/27900598/
https://doi.org/10.1515/dmdi.1988.6.3-4.275
Tetramethylenedisulfotetramine - https://doi.org/10.3390/TOXICS6030051.
Aldicarb - https://www.sciencedirect.com/topics/neuroscience/aldicarb
Batrachotoxin - https://www.sciencedirect.com/topics/neuroscience/batrachotoxin
Resiniferatoxin - an overview | ScienceDirect Topics https://www.sciencedirect.com/topics/neuroscience/resiniferatoxin
5,7-Dihydroxytryptamine - https://doi.org/10.1016/j.brainres.2007.02.052
Chloramphetamine - https://doi.org/10.1016/0006-2952(86)90332-1
Oxidopamine - https://www.sciencedirect.com/topics/neuroscience/oxidopamine
Penitrem A - https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/penitrem-a

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List of molecules for this video: Ethanol, Tetrodotoxin, Botulinum toxin, Tetraethylammonium, Methylmercury, Toxiferine, n-Hexane, MPP+, Anatoxin-A, Caramboxin, Turbocurarine chloride, Domoic acid, Strychnine, Tetraethyllead, Chlorpyrifos, TBPO, Neosaxitoxin, Carbon disulfide, TETS, Aldicarb, Resiniferatoxin, Batrachotoxin, 5,7-dihydroxytryptamine, Para-chloroamphetamine, Oxidopamine, Penitrem A.
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