The Secret Behind a Strange Stimulant

Like and subscribe. This is an archive channel, i'm not the owner of the content, check the link in the end. This is an investigation into why 8-chlorotheophylline is present as a stimulant in Gravol anti-nausea medication. A huge thanks to tay and yuyuhakase from the Discord!

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References:
1st patent - https://patents.google.com/patent/US2421714A/en
2nd patent - https://patents.google.com/patent/US2577234A/en
1st science paper - https://www.doi.org/10.1126/science.109.2832.359a
2nd science paper - https://www.doi.org/10.1126/science.109.2832.359.b
anti-nausea discovery - https://www.doi.org/10.1126/science.109.2840.574.a

Predicted pKa sources:
8-chlorotheophyline - https://www.chemicalbook.com/ProductChemicalPropertiesCB1401343_EN.htm
theophylline - https://pubchem.ncbi.nlm.nih.gov/compound/Theophylline
diphenhydramine - https://pubchem.ncbi.nlm.nih.gov/compound/Diphenhydramine

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