Carbon Trifluoromethylation (IOC 49)

Like and subscribe. This is an archive channel, i'm not the owner of the content, check the link in the end. In this video, I discuss the radical, nucleophilic, and electrophilic trifluoromethylation in C-CF3 bond forming reactions.Show more

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I forgot to mention in the video that the Ritter lab developed a TTF-CF3 reagent, which is promising as a versatile trifluoromethylating agent: https://doi.org/10.1021/jacs.1c02606

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Links to articles discussed in this episode:

Xe - https://www.doi.org/10.2174/978160805198410602010061
radical CF3 review - https://www.doi.org/10.1039/D1CS00200G
OG Langlois - https://www.doi.org/10.1016/0040-4039(91)80524-A
Langlois review - https://www.doi.org/10.1002/slct.202103867
Caffeine - https://www.doi.org/10.1073/pnas.1109059108
CF3SO2Cl - https://www.doi.org/10.1038/nature10647
CF3I - https://www.doi.org/10.1002/anie.201101861
TMS-CF3 review - https://www.doi.org/10.1021/cr400473a
CuCF3 review - https://www.doi.org/10.1055/s-0037-1611776
Best CuCF3 - https://www.doi.org/10.1039/C6RA10302B
cat. copper - https://www.doi.org/10.1002/chem.201405677
CF3H - https://www.doi.org/10.1126/science.1227859
Weibreb amide - https://www.doi.org/10.1039/C2CC35037H
ketone - https://www.doi.org/10.1002/ejoc.201101038
acyl phosphonium - https://www.doi.org/10.1002/chem.202102854
Trifluoromethylator - https://www.doi.org/10.1002/anie.201100633
silane - https://www.doi.org/10.1002/anie.201601163
Umemoto review - https://www.doi.org/10.1039/C4OB00671B
Togni review - https://www.doi.org/10.1021/cr500223h
Sulfoximinine - https://www.doi.org/10.1002/chem.202005104
alkenes - https://www.doi.org/10.1021/ja401022x
imidazolidinone - https://www.doi.org/10.1021/ja100748y
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