PfizerGate: What Robert Barnes is Missing
Mathew Crawford, Liam Sturgess and Gudrun Welder respond to Robert Barnes' comments about Project Veritas' #PfizerGate videos, and try to clarify what appears to be a miscommunication. We hope Robert will join us for a longer discussion so we can swap perspectives and hopefully enlighten each other!
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I didn't think a pharmaceutical company has the technical capability to perform gain-of function, or even directed evolution vis-à-vis their own private in-house stock of monkeys? I'm sure they (Pfizer) are every bit of evil as they say, but you got to have the technology to perform Gain-of-function. I could be wrong. I love Project Veritas. They still outed a Douch bag.
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have you read over Kevin Mckernan's substack article on directed evolution? and also, i dont think you can expect most lawyers and non scientists to distinguish the difference between GoF vs DE. But, Kevin Mckernan's point seems very valid. one more thing - whether Project Veritas was correct or not, it stirred a response from Pfizer and that response was very interesting - and i think Barnes was looking at this from lawyer's perspective that pfizer never denied the content of that Project Veritas video. like the response said 'in limited cases' - or the fact the response didnt mention about 3rd party affiliation doing GOF. but yes i agree, that it is reckless to jump in right away.
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OK, I have a question about your statement about what "hasn't happened in history", Matthew. The Covid Virus that swept the world recently escaped from or was deliberately released from a lab, and they lied about it for years, so their ability to weaponize viruses is a real thing that we cannot ignore. What hasn't happened in history is that scientists now have tools at their disposal that they never had before, would you not agree? Scientists today are doing a LOT of things that have never been done in history, some of which SHOULDN'T be done.
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It's not gain of function. It's directed evolution. All you need is hosts and monkeys will work fine.
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Just for clarity's sake.... DE is one method or mechanism used in GoF research by which genetic or molecular change is induced so as to result in a protein or gene acquiring a newly lost or enhanced activity. In other words, GoF research will use DE as a specific method ....among many others from which to choose... as the method most likely to result in a desired outcome.... And yup, spot on re: monkeys, for many Serial Passage/ (DE) GoF research projects.
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And without naming names, some of the players in this space are very committed to one political view & doing battle identifying that way, and really don't know the nuances in science. Neither do I, but I'm not leading any charges anywhere. I appreciate this political faction's willingness to expose corruption, but their side's hands are not spotless in the bigger drama of American corporate/social/political strategies. There seem to be few nonaligned, really objective voices. Thanks for all your work!
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(PART 1 OF 2) It appears from the Barnes clip herein, that there's a suggestion that Barnes is mistaken in asserting that GoF research exists? To say it doesn't exist Dr. Kanta Subbarao from the Infectious Disease at the National Institute of Allergy & Infectious Diseases (NIAID) Laboratory at the National Institutes of Health (NIH) opened the workshop on GoF by stating: "The field of virology, and to some extent the broader field of microbiology, widely relies on studies that involve gain or loss of function". Apart from eliminating a huge body of focus/work in Virology, is it your assertion that in its entire history of research across this country... the NIAID of the NIH or its research sponsored universities across this country have never once, altered a genotype and its resulting phenotype? (Gain e.g., higher yields for vaccine strains--- or loss, e.g., loss of the ability for a virus to replicate, would both be considered GoF research in the Virology /scientific world). How do you explain how vaccines are made (prior to this latest creation)? Is it possible that the difference of opinion on the existence of GoF.. perhaps exists in your differing definitions as to what is GoF? I hear how you define it... not sure why, you would so rigorously limit it to basically one technique (of many) where you use the word cloning a lot.. (is that what most would call genetic duplication as a mechanism.. ? I'm not sure... or are you basically referencing reliable replication as a hopeful outcome)? Your GoF definition doesn't at all follow the NIAID (who controls .. what 83% of all university research funding)? How are you connecting (scientifically) "robust" with replication. Are you adding the criterion of 'robust' to the criterion of reliable replication, as measuring a successful outcome... (outside of the lab)? or as a condition of longevity... or perhaps an indicator of virulence factors? [continued to next page]
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(2 of 2) The rigorously narrow definition of GoF given (to me, imo) sounds more like a (ultimately) conditions for successful outcome given one approach. I'd suggest more broadly and consistent with the Virology field, GoF is a genetic or molecular change that results in a protein or gene acquiring a new loss or enhanced activity by way of a variety of mechanisms (mutation, genetic duplication, introducing new domains or regulatory elements. Serial Passage using Directed Evolution with monkeys as the mechanism/method in achieving genetic change, resulting in a different/changed virus in GoF research... has been successful for decades. I'm sure from where comes the claim that GoF has never been successful? Subbarao (NIAID/NIH) states clearly: researchers now have advanced molecular technologies, such as reverse genetics, which allow them to produce de novo recombinant viruses from cloned cDNA".... "Researchers also use targeted host or viral genome modification using small interfering RNA or the bacterial CRISPR-associated protein-9 nuclease as an editing tool." BTW in that workshop Dr. Yoshihiro Kawaoka, from the University of Wisconsin-Madison suggested we classify types of GoF research depending on the outcome of the experiments. 1) "Viruses that don't exist in nature"... "The now famous example he gave is the production of H5N1 influenza A viruses". If you want to change the definition of what is GoF. its all good ... though I'd suggest you operationalize your terms (robust, clone etc) or traditional virologists aren't going to be able to follow you, absent having to guess what you mean. Using established vocabulary allowed an international group of us to talk fast/efficient & literally identify the HIV homologue inserted in the genome of the virus making people sick during C/Vid in Feb 2020 (on blast before it got nuked). CDC I think got it about year 1/2 later. Kuddos to Paul for catching /tracing it after a SE east Asia team first reported finding it.
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For a shorter response: It's happened many times in history. While Forbes is not even remotely what I'd consider primary source or a peer scientific journal... this Oct 22 report is but one of way too many to reference about the viral strains being created. Gain-Of-Function Experiments At Boston University Create A Deadly New Covid-19 Virus. Who Thought This Was A Good Idea? Virologists at Boston University took the Spike protein from the Omicron BA.1 strain of SARS-CoV-2 (that’s the strain that spread throughout the world last winter, ) and combined it with an early 2020 strain of the Covid-19 virus. This experiment gave them a brand-new, never-before-seen strain of Covid-19. Was it more deadly? You bet! “The Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%.” in mice. https://www.forbes.com/sites/stevensalzberg/2022/10/24/gain-of-function-experiments-at-boston-university-create-a-deadly-new-covid-19-virus-who-thought-this-was-a-good-idea/?sh=3c4b95c95ca3
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you sound like fauci. gain of function per say or not. lets look at the intent of what pfizer wanted to do.
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I have no doubt that Pfizer is acting in bad faith. Their intent is clear.
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