How “Ozempic” Works – Weight Loss, Weight Regain, & Neuroscience | Nick Sterling, MD, PhD #7
How do drugs like Ozempic (semaglutide) cause weight loss? What happens when someone comes off of these drugs? In this episode, we discuss how these drugs (GLP-1 receptor agonists) target specific areas in the brain to suppress appetite and facilitate weight loss. We also discuss clinical trials data suggesting that these drugs and/or the weight loss that they facilitate may have cardioprotective effects. Lastly, we will also examine evidence regarding weight regain when coming off of these drugs and common side effects.
Link to episode on neuroscience of appetite regulation:
https://www.youtube.com/watch?v=i3RzV9vS_FA
#healthspan, #semaglutide, #ozempic, #wegovy, #science, #weightloss
Chapters:
00:00 - Intro
01:31 - What Does GLP-1 Do?
02:08 - GLP-1 Receptors in the Brain
02:52 - Activating the GLP-1 "Switch" (Receptors)
04:13 - Clinical Trials - Semaglutide for Weight Loss
05:29 - Semaglutide and Heart & Metabolic Health
05:54 - For How Long Does Semaglutide Work?
06:35 - Weight Regain After Stopping Semaglutide
08:24 - Side Effects of GLP-1 Receptor Agonists
09:37 - Take-Home Points
10:20 - Outro
Social & Website:
Instagram - https://www.instagram.com/sterlingmdphd
Twitter - https://twitter.com/sterlingmdphd
Facebook - https://www.facebook.com/sterlingmdphd
TikTok - https://www.tiktok.com/@sterlingmdphd
Newsletter - http://eepurl.com/hQpdqT
Subscribe to the Podcast:
Apple Podcasts: https://apple.co/3y438C9
Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c
Google Podcasts: https://bit.ly/3Olanei
References & Show Notes:
http://www.nicksterling.com/
The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. The content of this podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.
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How Ultra-Processed Foods Drive Weight Gain | Nick Sterling, MD, PhD #5
Growing scientific evidence suggests that highly processed foods are associated with increased risk of disease. Until recently, scientists were unable to study directly the effects of highly processed foods on humans. In this episode, we review one of the first highly controlled scientific trials demonstrating that ultra-processed foods lead to weight gain.
#diet, #weightloss, #science, #fitness, #food
Neuroscience of appetite regulation: https://youtu.be/i3RzV9vS_FA
Chapters:
00:00 - Intro to Ultra-Processed Foods
00:55 - What are Ultra-Processed Foods?
02:14 - Disease & Ultra-Processed Foods
03:19 - Interventional Study
04:24 - Ultra-Processed Foods & Weight Gain
05:44 - Take-Home Points
06:57 - Outro
Social & Website:
Instagram - https://www.instagram.com/sterlingmdphd
Twitter - https://twitter.com/sterlingmdphd
Facebook - https://www.facebook.com/sterlingmdphd
TikTok - https://www.tiktok.com/@sterlingmdphd
Newsletter - http://eepurl.com/hQpdqT
Subscribe to the Podcast:
Apple Podcasts: https://apple.co/3y438C9
Spotify: https://open.spotify.com/show/5TDUK3F2sJXfnG63hSxJhT?si=40bb52e5b53f404c
Google Podcasts: https://bit.ly/3Olanei
References & Show Notes:
http://www.nicksterling.com/
Legal:
The content of this video is for general information purposes only and does not constitute the practice of medicine or any other healthcare professional services. The content of this video is not medical advice. No doctor-patient relationship is formed. This podcast should not take precedence over information provided to you by your healthcare provider or official public health sources. Please visit nicksterling.com/terms for full Terms of Use.
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Ultra-Processed Foods, Weight Gain, & Weight Loss
Ultra-processed foods have been shown to influence caloric intake, leading to weight gain via adipose tissue accumulation. Conversely, participants lost weight when switched to a diet of minimally processed foods. #fitness, #weightloss, #diet, #food , #science
How the Best Athletes "Burn" Fat for Fuel - Endurance Metabolism | Nick Sterling, M.D., Ph.D. #2
In this episode, we discuss fat through the lens of performance and survival, and what happens when we push our energy systems to their limits. We also talk about how our bodies make adaptations via exercise to improve our ability to "burn" fat for fuel, and how our bodies conserve fuel during times of negative energy balance. Lastly, we preview the role of fat as an endocrine organ and the importance of its communication with the brain, as well as the critical role of exercise capacity for our future health.
Chapters:
00:00 - Introduction
01:49 - Extreme Endurance
02:54 - Fuel Source & Effort
03:12 - Glycogen
05:16 - Using Fat for Fuel
08:48 - Known Limits of Prolonged Energy Expenditure
10:21 - Metabolic Rate & Endurance Duration
14:00 - Physiology of Fat
16:18 - Insulin & Catecholamines in Fat Metabolism
19:10 - Fat as an Endocrine Organ
21:05 - Exercise & Maximal Fat Oxidation
22:02 - Exercise & Future Health
22:55 - Summary
Social & Website:
Instagram - https://www.instagram.com/sterlingmdphd
Twitter - https://twitter.com/sterlingmdphd
Facebook - https://www.facebook.com/sterlingmdphd
TikTok - https://www.tiktok.com/@sterlingmdphd
Newsletter - http://eepurl.com/hQpdqT
Subscribe to the Podcast:
Apple Podcasts: https://apple.co/3y438C9
Spotify: https://spoti.fi/3mZDvMv
Google Podcasts: https://bit.ly/3Olanei
References & Show Notes:
http://www.nicksterling.com/
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How Our Food Environment Drives Weight Gain | Nick Sterling, M.D., Ph.D. #1
This is our first episode on weight gain and weight loss. In this episode, we describe how, as an industrialized nation, our food supply and environment have changed in a way that, in many cases, is mismatched with our biology as humans. We explore how these changes can lead to disease and metabolic dysfunction. We discuss how the replacement of whole foods with processed foods, as well as the addition of caloric sweeteners to most of the food items within grocery stores across the nation has preceded a rapid rise in obesity and metabolic dysfunction. In this episode, we begin to discuss some of the pathophysiology related to the consumption of ultra-processed and hyper-palatable foods as well as concerns surrounding the consumption of fructose- and glucose- containing sugary drinks. We also discussed the timelines of weight gain and loss as they typically occur over the lifespan and vary according to season. This episode sets the stage for the next episodes, which will focus on the normal fat metabolism and how it may become dysregulated in metabolic dysfunction.
Chapters
00:00 - Introduction
01:21 - Metabolic health as a continuum
03:57 - Obesity as an epidemic
05:12 - Heritability and genetics of obesity
06:45 - Where obesity starts in the body
07:26 - History of weight gain in the U.S.
11:32 - High fructose corn syrup vs. table sugar
13:40 - Glycemic index and load
14:45 - What happens to your liver with sugary drinks
16:24 - Sugary drinks may be associated with cancerous changes
17:35 - The calories from sugary drinks are not automatically offset
20:24 - Obesity as a disease
23:10 - Obesity and kids
24:24 - How obesity develops across the lifespan
26:55 - The impacts of weight loss attempts
30:12 - Summary and upcoming content
Social & Website
Instagram - https://www.instagram.com/sterlingmdphd
Twitter - https://twitter.com/sterlingmdphd
Facebook - https://www.facebook.com/sterlingmdphd
TikTok - https://www.tiktok.com/@sterlingmdphd
Website - https://nicksterling.com
Newsletter - http://eepurl.com/hQpdqT
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