LongStoryShort

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Join the channel to help us make more videos: https://www.youtube.com/channel/UCd-MyawrutjiUKl-DfbQ0vQ/join Imagine you discovered a stone with ancient words carved into it! And they told a really good knock-knock joke. What an archaeological find! But to your surprise, scientists concluded that it came about through purely natural processes: “just physics and chemistry acting on an exposed rock.” What? You’d need very specific lines and shapes to form letters, and then those letters would need to be in very specific arrangements to even get a bad knock knock joke. “Well, if you leave rocks out in the wind and rain for long enough, you’re bound to get knock knock jokes eventually.” Nobody would buy that. But this is eerily similar to typical explanations for the origin of life, except life is no joke (pun intended), and there are many more layers of complexity that would have to come together to kickstart life.

Our next video on the origin of life is coming out soon! This time taking a closer look at molecular replication and the RNA WORLD hypothesis. **Be sure to subscribe to get notified when it's released!**

Could life have started from simply natural processes? Little bit of chemistry here, a dash of physics there — a LOT of time… and boom! We’ve got the beginning of life, abiogenesis…right? We’ve already detailed a number of serious issues with abiogenesis (chemical evolution) in previous videos, but we’ll just assume that all of the scientific challenges mentioned in all these prior videos have been vaporized... #originoflife #evolution

Some really smart people, from Charles Darwin to scientists today, believe in abiogenesis. A “primordial soup” and led to life as we know it. But is this really the case? 1. “if (and oh what a big if) we could conceive in some warm little pond with all sorts of ammonia & phosphoric salts,—light, heat, electricity etc. present, that a protein compound was chemically formed, ready to undergo still more complex changes” — Charles Darwin To J. D. Hooker, 1 February [1871] https://www.darwinproject.ac.uk/letter/DCP-LETT-7471.xml 2. “The theory of chemical evolution states that monomers in the prebiotic soup polymerized to form larger and more complex molecules, such as the proteins and other types of macromolecules found in organisms.” Biological Science, Freeman, 5th ed. pg. 44 3. “biologists now have evidence that life did arise from nonlife early in Earth’s history, through a process called chemical evolution [namely miller-like experiments]” Biological Science, Freeman, 5th ed. pg 4 4. [Re: The Miller-Urey experiment] Chemical evolution occurs readily if simple molecules with high free energy are exposed to a source of kinetic energy.” Biological Science, Freeman, 5th ed. pg 33 5. “Based on data from Stanley Miller and researchers who followed, most biologists contend that amino acids could have been synthesized early in Earth’s history.” [note pointing to “amino acids” “building blocks life needs to get going”] Biological Science, Freeman, 5th ed. pg 59 6. "The consensus is that life did arise naturally from the nonliving … the conclusion has, indeed, really become inescapable, for the first steps in that process have already been repeated in several laboratories". – George Gaylord Simpson, Commenting on the results from the Miller-Urey experiment in the prestigious journal "Science", The World Into Which Darwin Led Us. Science 1960. 131: 966-974. 7. “There was some optimism that, had the experiment been left running, living creatures would soon be crawling out of the laboratory.” –Walker SI, Packard N, Cody GD. 2017 Re-conceptualizing the origins of life. Phil. Trans. R. Soc. A 375: 20160337. http://dx.doi.org/10.1098/rsta.2016.0337 8. *Toxic in the chemical sense; that is, it reduces or prevents desired chemical reactions. Many necessary ingredients for abiogenesis are also toxic to existing life. That, while interesting, is not the criticism here. For example: hydrogen cyanide (once used as a chemical warfare agent) and formaldehyde (the active ingredient in embalming fluid). 9. A. Wotos el al., "Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry," Science (2020). https://science.sciencemag.org/content/369/6511/eaaw1955 10. Generation Round 7 of Synthesis Date: 82 Biotic Molecules generated / 36,685 Cumulative Sum of All Molecules = 99.777% Ratio of Abiotic to Biotic Molecules. This problem would be compounded greatly with more time and successive rounds of generation. 11. *technical note: Unwanted cross reactions would leave these amino acids unable to properly interact to fold into functional proteins. Sort of like a lock packed with concrete or gum. Not to mention the various problems of dilution, chirality, and stability if polymers could form. 12. The Murchison meteorite contained “tens of thousands of different molecular compositions, and likely millions of diverse structures,” which “suggests that the extraterrestrial chemodiversity is high compared to terrestrial relevant biological- and biogeochemical-driven chemical space” Translation: For each molecule you did want there are innumerable things we don’t want and would get in the way. [Schmitt-Kopplin, P., et al., High molecular diversity of extraterrestrial organic matter in Murchison meteorite revealed forty years after its fall. Proc Natl Acad Sci U S A, 2010. 107(7): 2763–2768.] 13. Ruiz-Bermejo, M., Menor-Salvan, C., Osuna-Esteban, S., Veintemillas-Verdaguer, S., 2007. Prebiotic microreactors: a synthesis of purines and dihydroxy compounds in aqueous aerosol. Origins of Life and Evolution of the Biosphere 37, 123e142. 14. “[Miller & Urey] showed that organic molecules (in this case amino acids) could be created from inorganic materials by natural environmental conditions” https://www.americanscientist.org/article/the-origin-of-life 15. "Geochemical Sources and Availability of Amidophosphates on the Early Earth" Gibard C, Gorrell IB, Jiménez EI, Kee TP, Pasek MA, Krishnamurthy R. Geochemical Sources and Availability of Amidophosphates on the Early Earth. Angew Chem Int Ed Engl. 2019 Jun 11;58(24):8151-8155. doi: 10.1002/anie.201903808. 16. “Ribose is the sugar that is the building block to produce RNA. Ribose rapidly decomposes in aqueous solution. The half-life of ribose is 73 min at 100 oC and pH 7.0, and 44 years at 0 oC and pH 7.0.” The authors also point out that the degradation rate of ribose in a prebiotic ocean could have been even faster, considering that the pH of the ocean today is 8.2 (more than 10x more alkaline) than neutral pH, which would increase the ribose destruction rate by ~50%. Larralde, R., Robertson, M.P., Miller, S.L.*, 1995. Rates of decomposition of ribose and other sugars: implications for chemical evolution. Proceedings of the National Academy of Sciences of the United States of America 92, 8158e8160. 17. “Nucleobases have relatively short lifetimes in aqueous solution; the half-lives of A, C, G, T and U at 100 oC and pH 7 are 1 year, 19 days, 0.8 years, 56 years and 12 years, respectively.” – Levy, M., Miller, S.L., 1998. The stability of the RNA bases: implications for the origin of life. Proceedings of the National Academy of Sciences of the United States of America 95, 7933e7938. 18. Chart adapted from © 2003 International Union of Biochemistry and Molecular Biology 22nd Edition Designed by Donald E. Nicholson, D.Sc., The University of Leeds, England – and Sigma-Aldrich. Used with permission. 19. For more information: The Stairway to Life https://www.amazon.com/Stairway-Life-Origin-Life-Reality/dp/1734183705 The mystery of Life’s Origin https://www.amazon.com/Mystery-Lifes-Origin-Charles-Thaxton/dp/1936599740

Bacterial evolution and antibiotic resistance is one of the all time greatest hits regarding evidence for Evolution. It’s true that antibiotics do stop working sometimes, AND antibiotic resistance is a form of evolution. But is this a demonstration of the creative power of Darwinian evolution, or is there something else going on? Ecocyc, E. coli citrate related genes: https://ecocyc.org/ECOLI/NEW-IMAGE?type=MAPTICK&object=645100/654550&chromosome=COLI-K12&bp-range=645100/654550 Richard Lenski on his lab work: https://www.youtube.com/watch?v=PQr8ldEeO04 AP News article: https://apnews.com/article/cdadad7ccc304ab7dc54b5e52feebdda If you have any feedback or criticism, let us know and I’ll try to address it (please be civil): longstoryshort@discovery.org