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Say hello to “Won” one hundred days ago Stella had a litter of 12 puppies, and won was the smallest one, I call him Won because he won the lottery of life and survived despite being the smallest one… After finishing up on the distillation process we go over a couple of things such as Volatile components distilled out of the 6 mushroom blend, to be reintroduced into the composite mix, this video was shot to provide the information of the previous gravity filtered initial Glycerine extraction, of roughly 100 ml, the distillation process using ethanol to break down the solids left over from the gravity filtration of glycerine, is inundated by 300 ml glycerine, this allows the left over solids to be removed from the distillation flask, and towards the further amount ending 900ml of mushroom vape juice including 15-20 ml of the evaporated volatile components. All this finished after the recording of these two videos, i was depressed that it took two days of retrying to upload the videos and simply finished without recording. Last part we talk about my preferred devices… Thank you for watching

Trying to upload this for a whole day, as i have a follow up right away, this I believe is the finished ethanol extraction, and the process of gravity filtration begun, adding 300ml 70/30 Glycerine the batch being 900ml when all is done. Wanted to make the video today on this, but not uploading was worrisome, so I just completed the process and have my Bach finished, however, in this video I show how to remove the sticky “pulp” from the distillation flask. By adding glycerine…

Building the ethanol rig, while waiting for the mushroom glycerin extraction to gravity filter

Measuring 1 gram of each mushroom Agarikon, Cordyceps, Lions mane, Chaga, Turkey Tail, and Tiger Milk Thank you for watching

Getting the rig out of the box, scale and mixer, readying to start the process for making Mushroom Vape.

Reading the Diary of John Evelyn part one

Just searching for related articles on the 6 mushroom blend Agarikon, Cordyceps, Turkey Tail, Chaga and Lions Mane… Fresh-Cap Mushrooms Cited works: https://themedicinalmushroomcompany.com/blogs/the-medicinal-mushroom-co-journal/agarikon-the-mushroom-of-longevity https://healing-mushrooms.net/agarikon https://www.healthline.com/nutrition/cordyceps-benefits Video: https://youtu.be/Qi7JV1Sy4Wk dont know if they’ve used rumble yet. https://www.healthline.com/nutrition/lions-mane-mushroom 9 Health Benefits of Lion's Mane Mushroom (Plus Side Effects) Protects against dementia. Relieves mild depression and anxiety. Speeds nervous system injury recovery. Protects against ulcers. Reduces heart disease risk. Helps manage diabetes symptoms. May help fight cancer. Reduces inflammation. One more Mushroom Tiger Milk Mushroom, I havent spotlighted in this video Advocacy for Mushroom Vape.

Cited paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8304235/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817425/ Table 2 List of studies on protein and carbohydrate contents in edible fungi from different geographical locations from 2010–2021. Fungal Species Wild or Cultivated Location Composition References 24 Chilean wild and commercial edible mushrooms from genera Agaricus, Agrocybe, Boletus, Cortinarius, Cyttaria, Flammulina, Grifola, Lactarius, Lentinus, Macrolepiota, Morchella, Pleurotus, Ramaria, Suillus, Tricholoma, and Xeroco-mus Wild and cultivated mushrooms Ñuble and Bio-Bio Regions, Chile Crude protein content: 8.56–23.88 g/100 g d.w. (Highest in Cortinarius lebre (Chilean endemic mushroom)); Carbohydrate content: 62.97–83.65 g/100 g d.w. (highest in Marcolepiota procera); [124] Volvariella volvacea Cultivated mushroom Solan, India Protein content: 32%; Carbohydrate content: 52.2% [125] Clavaria rosea, Ganoderma sp., Geastrum triplex, Hygrocybe parvula, Schleroderma bermudense Wild mushrooms Shivamogga District, Karnataka, India Protein contents: 25.71–36.51% (highest in Hygrocybe parvula); Carbohydrate contents:37.38–48.63% (highest in Ganoderma sp.) [126] Pleurotus pulmonarius RN2, P. djamor RN81 and RN82 Cultivated mushrooms (cultivated on rice straw (Oryza sativa L.), corn stubble and husk (Zea maize L.)) USA and Panama Protein contents: 23.54–43.07% (highest in RN82 cultivated on corn husk); carbohydrate contents: 27.39–52.44% (highest in RN2 cultivated on corn stubbles) [127] Lentinus sajor-caju and Lentinus torulosus Wild mushrooms Similipal Biosphere Reserve, India protein content: 27. 31–28. 36 g/100 g; carbohydrate content: 64. 95–68. 24 g/100 g. [128] Amanita crocea (Quél. in Bourd.) Singer ex Singer, Amanita mairei (Foley), Boletus porosporus (Imler ex Bon & G. Moreno), Boletus regius (Krombh.), Gyromitra esculenta (Pers. ex Pers.) Fr., Helvella lacunose (Afzel.), Russula aurea Pers., Russula virescens (Schaeff.)Fr. Wild mushrooms Bragança (Northeast Portugal) Protein content: 4.40–21.85 g/100 g d.w. (highest in Rusula virenscens); Carbohydrate content: 49.64–88.79 g/100 g d.w. (highest in Boletus regius). [129] Agaricus bohusii Bon Wild mushroom Jabučki rid, Northern Serbia Protein content: 18.06 g/100 g dw; carbohydrate content: 69.79 g/100 g d.w. [130] Fistulina hepatica, Infundibulicybe geotropa, Laetiporus sulphureus, Macrolepiota procera var. procera and Suillus granulatus Wild mushrooms Sicily, Southern Italy Protein contents: 1.31–4.37 g% (highest in L. sulphureus); carbohydrate contents: 2.08–4.57 g% (highest in I. geotropa) [131] Cantharellus isabellinus, C. cibarius var. longipes, C. rhodophyllus, C. miniatescens, C. appalachiensis, C. cibarius, C. natarajanii, C. fibrillosus, C. lateritius, C. applanatus, Cr. cibarius var. intermedius C. himalayensis, C. elongatipes, C. cibarius var. multiramis, C. indicus, C. pseudoformosus, C. umbonatus, C. minor Wild mushrooms Northwestern Himalayas, India Protein: 21.6–43.2 mg/g (highest in C. miniatescens); carbohydrate: 9.94–26.5 mg/g (highest in C. minor) [132] Armillaria mellea (Vahl) P. Kumm., Calocybe gambosa (Fr.) Donk, Clitocybe odora (Fr.) P. Kumm., Coprinus comatus (O.F. Müll.) Pers. Wild mushrooms Bragança, Northeast Portugal Protein: 15.46–17.33 g/100 g dw (highest in Clitocybe odora); carbohydrates: 69.83–71.28 g/100 g dw (highest in Armillaria mellea) [133] Pleurotus florida, P. sajor-caju and P. ostreatus Cultivated mushrooms (cultivated on bean straw) Pantnagar, India Protein contents: 30.92–36.75% db (highest in Pleurotus sajor-caju); carbohydrate contents: 0.49–31.59% db (highest in Pleurotus florida) [134] Agaricus campestris, Boletus edulis, Calocybe gambosa, Cantharelluscibarius, Calocybe cornucopioides, Entoloma clypeatum, Flammulina velutipes, Macroleptiotaprocera, M. elata, Pleurotus ostreatus Wild mushrooms Croatian regions of Istria (northwest) and Slavonia (northeast) Protein: 24.22–47.21 g/100 g dw (highest in C. cornucopioides); carbohydrates: 24.6–66.78 g/100 g (highest in Macroleptiota procera) [135] Boletus aereus Bull., Boletus edulis Bull., Boletus reticulatus Schaeff. Wild mushrooms Bragança, Northeast Portugal Protein: 17.86–22.57 g/100 g (highest in Boletus reticulatus); carbohydrates: 55.16–72.83 g/100 g (highest in Boletus aereus Bull. [136] Candida valida Edible yeast isolated from babies’ weaning food produced from fermented corn (Ogi) and grown on synthetic medium and cane molasses Japan Protein: 42.6–44.3% (highest when cultured using cane molasses); carbohydrate: 26.9–28.8% (highest when cultured using synthetic medium) [137] Polyporus tenuiculus Cultivated mushroom (cultivated in supplemented and nonsupplemented wheat straw and willow sawdust) Argentina Protein: 15.1–22.5% (highest when cultivated using wheat straw supplemented with soybean flour (5%) and wheat brand (15%)); carbohydrate: 47.2–51.6% (highest when cultivated using willow sawdust) [138] Terfezia boudieri Wild desert truffle Ben Guerdane, Southeast Tunisia Protein: 10.5%, 15.4% total sugars [139] Terfezia boudieri Wild desert truffle Hilvan- Sanliurfa, Yenice/Ceylanpinar/Sanliurfa, Polatlı/Ceylanpinar/Sanliurfa, Kiziltepe-Mardin and Malatya from Southeast of Turkey Protein 1.40–2.73 g/100 g carbohydrate: 4.84–12.30 g/100 g (highest from Kiziltepe/Mardin) [140] Astraeus hygromatricus Wild edible fungus South-west India 11.71% and 4.66% protein from inner and outer part of the fruit bodies, 29.48% and 35.41% carbohydrate from inner and outer fruit bodies [141] Pleurotus ostreatus Cultivated mushroom (cultivated on oat straw (control), blank paper scraps and printed paper scraps) Portugal Protein contents: 9.29–14.7 g/100 g (highest when cultivated on oat straw; Carbohydrate contents: 73.2–78.6 g/100 g (highest when cultivated in printed paper) [142] Pleurotus florida and P. eous Cultivated mushrooms (cultivated on paddy straw that has been added with either chicken manure, rice bran, wheat bran, black gram, green gram, or horse gram.) Tamil-Nadu, India Protein contents: 3.4–35.2% dwt. (highest when cultivated on paddy straw with chicken manure); carbohydrate contents: 31–63.8% dwt. (highest when cultivated on paddy straw with green gram) [143] Boletus edulis, Boletus mirabilis, and Lactarius deliciosus Wild mushrooms KwaZulu-Natal, South Africa Protein contents: 17.5–39.0% (highest in B. edulis); carbohydrate content: 51.7–76.0% (highest in L. deliciosus) [144] Pleurotus pulmonarius Cultivated mushroom Sao Paolo, Brazil Protein contents: 31% in Basodioma, 32% in Mycelium; Carbohydrate contents: 30% of the aqueous solution [145] Pleurotus eryngii, Dictyophora indusiata (Vent. ex Pers) Fisch, Agrocybe aegerita, Ganoderma lucidum (Leyss. ex Fr.) Karst., Yanshan Agaric, Pholiota nameko Ito ex Imai., Hericium erinaceus, Copyinds comatus (MUII. Fr) Gray, Tremella, Cordyceps militaris, Lentinus edodes (Berk.) Sing, Auricularia auricula (L.ex Hook.) under wood, Agaricus blazei Murrill, Volvariella volvacea (Bull.:Fr.) Sing., Morchella esculenta, Griflola frondosa, Arimillaria mellea, Boletus, Russula vinosa Lindblad, and Sparassis crispa. - China Protein contents: 9.31–37.23% (highest in Tricholoma Shiitake); Carbohydrate contents: 0.54–37.23% (highest in Pleurotus eryngii); Ganoderma lucidum (Leyss ex Fr.) Karst. Yashan has the lowest protein and carbohydrate contents. [146]

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Documented human use of tobacco at least 8000 years, and in the old world since it has been brought back… I would like at least social acceptance for vaping of Mushrooms. Mushrooms have been eaten since we first saw them… Cited works https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778268/?report=reader https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197479/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968029/ Adenosine is a purine nucleoside base, most commonly recognized with the molecule adenosine triphosphate, or ATP, and is used thoroughly throughout the entire body in general metabolism.[6] Adenosine's use as a pharmacological drug works through receptors called purinergic adenosine receptors found throughout the body. The adenosine analogue cordycepin (3′-deoxyadenosine) is a unique fungal product isolated from the traditional medicine fungi Cordyceps militaris (Cunningham et al., 1950) and Ophiocordyceps sinensis (Figure 1D) (Zhou et al., 2008). Interestingly, cordycepin is known to have broad‐spectrum pharmacological properties against several diseases (e.g., virulent RNA viruses) and multi-organ protective effects (e.g. acute lung injury). Specifically, cordycepin is a promising therapeutic against several viruses in vitro, including dengue virus, And thank you for taking your time to watch, my Advocacy for mushroom vape…

Cited https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175741/ A clinical study on the effects of tiger milk mushroom on 50 subjects… Uhm i never know why this do this Discussion This study is the first to report the beneficial effects of TMM on respiratory health through clinical approach. Our findings revealed that TMM supplementation is effective in improving overall respiratory health and immunity of the participants. Few parameters being assessed as the indicator of respiratory health has shown a significant improvement by the end of this study. Those parameters included pulmonary function, respiratory symptoms, VAS, interleukin level and immunoglobulin level. Ratio of FEV1 to FVC that reflects pulmonary function has shown 27.2% improvement after three months of TMM supplementation.. ... Apart from inhibitory action against TNF-α production, TMM also exhibited regulatory effect against macrophages4. The regulatory effect of TMM was suggested to be attributed by its high linoleic acid content. Linoleic acid inhibits inflammatory responses from macrophage through inactivation of nuclear factor (NF)-kappaB and activator protein-1 (AP-1) by suppressing oxidative stress and signal transduction pathway of signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-136. …The suppressing effect of TMM on overproduction of IL-1β and IL-8 is crucially important to conserve the lungs’ function and to prevent any damage from pro-inflammatory cytokines40. The improved pulmonary function, NSQ and VAS scoring from our findings have further validated that. Recent study suggested that any treatment targeting cytokine could potentially be an evolving treatment strategy in chronic inflammatory airway diseases15. …NSQ is a simple and accurate scoring system developed specifically to evaluate the symptoms caused by sinonasal diseases, such as sneezing, nasal obstruction, nasal discharge, olfactory loss, cough and quality of life… Sinonasal disease was mainly triggered by persistent or recurrent episodes of infection or inflammation of one or both sinus cavities43... …TMM supplementation is important to prevent colonization of respiratory tract by pathogens and penetration of antigens through epithelial cells. The antiviral properties of IgA were well established by studies on Sendai virus, influenza virus, and rotavirus51. Most recent studies also suggested the potential role of IgA in fighting SARS-CoV-2 infection12,13.. …Recent review pointed out that although definitive data is still lacking, but available evidences suggested that dietary intake of antioxidant is closely associated with better pulmonary function, less lung function decline and reduced risk of COPD56. Our result indicated that three months of TMM supplementation can effectively increase total antioxidant capacity by almost 70%… …TMM supplementation could potentially exert a protective effect against inflammation-related respiratory diseases as polyphenols had been proven to effectively reduce inflammation, by (1) up-regulating antioxidant gene expression, (2) attenuating endoplasmic reticulum stress signalling, (3) blocking pro-inflammatory cytokines, (4) suppressing inflammatory gene expression by stimulating histone deacetylase activity, or (5) activating transcription factors that antagonize chronic inflammation61… …Similarly, oral administration of TMM in diabetic animal model also found that elevated glutathione (GSH) level, superoxide dismutase (SOD), and catalase (CAT) activities to be associated with reduced lipid peroxidation66. Reduced lipid peroxidation is important to prevent many detrimental effects on airway function which were caused by oxidative stress, including airway hyperresponsiveness67, mucus hypersecretion68, epithelial shedding69, airway smooth muscle contraction70, vascular exudation71, and increased vascular permeability72. Conclusion: Although TMM is well-known for its ethnomedicinal uses in curing many ailments and to improve respiratory health, but scientific evidences that supporting its therapeutic uses were limited to in vivo and in vitro models. Present work is the first to study the efficacy of TMM supplementation to improve respiratory health through a clinical approach. Findings revealed that TMM supplementation can effectively improve the respiratory health, immunity, as well as overall antioxidant status. Thus, suggesting TMM supplementation as a potential adjuvant therapy to the current drugs used for the management of respiratory diseases. Nonetheless, the lack of a placebo group is one important limitation in this study. Randomized controlled trial is recommended for future study to validate our findings. In addition, this study was not registered with any Clinical Trial Registry and will consider registering future studies.

A few seconds while I pick it up, hehehe It survived 😁🤩

Cited https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175741/ A clinical study on the effects of tiger milk mushroom on 50 subjects… It is my hopes to get together a facility, a lounge/spa, with a pulmonologist to help with an observational study, of those of whom buy in to participate, and monthly we record their pulmonary improvements… Discussion This study is the first to report the beneficial effects of TMM on respiratory health through clinical approach. Our findings revealed that TMM supplementation is effective in improving overall respiratory health and immunity of the participants. Few parameters being assessed as the indicator of respiratory health has shown a significant improvement by the end of this study. Those parameters included pulmonary function, respiratory symptoms, VAS, interleukin level and immunoglobulin level. Ratio of FEV1 to FVC that reflects pulmonary function has shown 27.2% improvement after three months of TMM supplementation.. ... Apart from inhibitory action against TNF-α production, TMM also exhibited regulatory effect against macrophages4. The regulatory effect of TMM was suggested to be attributed by its high linoleic acid content. Linoleic acid inhibits inflammatory responses from macrophage through inactivation of nuclear factor (NF)-kappaB and activator protein-1 (AP-1) by suppressing oxidative stress and signal transduction pathway of signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-136. …The suppressing effect of TMM on overproduction of IL-1β and IL-8 is crucially important to conserve the lungs’ function and to prevent any damage from pro-inflammatory cytokines40. The improved pulmonary function, NSQ and VAS scoring from our findings have further validated that. Recent study suggested that any treatment targeting cytokine could potentially be an evolving treatment strategy in chronic inflammatory airway diseases15. …NSQ is a simple and accurate scoring system developed specifically to evaluate the symptoms caused by sinonasal diseases, such as sneezing, nasal obstruction, nasal discharge, olfactory loss, cough and quality of life… Sinonasal disease was mainly triggered by persistent or recurrent episodes of infection or inflammation of one or both sinus cavities43... …TMM supplementation is important to prevent colonization of respiratory tract by pathogens and penetration of antigens through epithelial cells. The antiviral properties of IgA were well established by studies on Sendai virus, influenza virus, and rotavirus51. Most recent studies also suggested the potential role of IgA in fighting SARS-CoV-2 infection12,13.. …Recent review pointed out that although definitive data is still lacking, but available evidences suggested that dietary intake of antioxidant is closely associated with better pulmonary function, less lung function decline and reduced risk of COPD56. Our result indicated that three months of TMM supplementation can effectively increase total antioxidant capacity by almost 70%… …TMM supplementation could potentially exert a protective effect against inflammation-related respiratory diseases as polyphenols had been proven to effectively reduce inflammation, by (1) up-regulating antioxidant gene expression, (2) attenuating endoplasmic reticulum stress signalling, (3) blocking pro-inflammatory cytokines, (4) suppressing inflammatory gene expression by stimulating histone deacetylase activity, or (5) activating transcription factors that antagonize chronic inflammation61… …Similarly, oral administration of TMM in diabetic animal model also found that elevated glutathione (GSH) level, superoxide dismutase (SOD), and catalase (CAT) activities to be associated with reduced lipid peroxidation66. Reduced lipid peroxidation is important to prevent many detrimental effects on airway function which were caused by oxidative stress, including airway hyperresponsiveness67, mucus hypersecretion68, epithelial shedding69, airway smooth muscle contraction70, vascular exudation71, and increased vascular permeability72. Conclusion: Although TMM is well-known for its ethnomedicinal uses in curing many ailments and to improve respiratory health, but scientific evidences that supporting its therapeutic uses were limited to in vivo and in vitro models. Present work is the first to study the efficacy of TMM supplementation to improve respiratory health through a clinical approach. Findings revealed that TMM supplementation can effectively improve the respiratory health, immunity, as well as overall antioxidant status. Thus, suggesting TMM supplementation as a potential adjuvant therapy to the current drugs used for the management of respiratory diseases. Nonetheless, the lack of a placebo group is one important limitation in this study. Randomized controlled trial is recommended for future study to validate our findings. In addition, this study was not registered with any Clinical Trial Registry and will consider registering future studies. A class act…

Tiger milk Cited: https://szuting.wixsite.com/ligno/product https://pubmed.ncbi.nlm.nih.gov/36164453/ Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509233/ Malaysian national treasure Tiger Milk Mushroom has more than 400 years history in medical use, as quoted and called as “Lac Tygridis” by John Everlyn, a European government servant, in his “The Diary of John Everlyn” in 1664. He also reported that Tiger Milk Mushroom was used by the local people to treat diseases that European doctors found no cure for. The sclerotium of this mushroom is where all the medicinal benefits come from. Wild and cultivated varieties are found comparative. The bioactive compounds of medicinal mushrooms could be isolated from the mycelium, sclerotia and fruiting bodies during the growth process [25]. These biochemicals with pharmacological effects play a preventive and therapeutic role in disease. Polysaccharides are one of the therapeutic compounds of L. rhinocerotis, and numerous studies have shown that PLR is related to antitumor and immunomodulatory effects [26–29]. Phenolic compounds, as natural antioxidants, was able to scavenge free radicals, and the quantification of total phenolic content and total flavonoid content can be used as indicators to evaluate antioxidant capacity. Among the proximate analysis of physicochemical contents, the extraction rates of LRR (7.98%) was higher than those of LRS (5.37%) and LRW (1.86%) and the physicochemical content of cultivated LR was 4~5 times higher than wild L. rhinocerotis, which could be explained by the uncertain harvesting time and the harsh living conditions in the wild; conversely, the cultivated L. rhinocerotis was harvested under relatively fertile conditions. Per gram of dry aqueous extract, LRW had the highest polysaccharide content. LRS had the highest flavonoid and polyphenol contents. In short, both cultivated and wild L. rhinocerotis are abundant in bioactive compounds. Most diseases are closely related to the excessive secretion of free radicals, and the excessive production of free radicals leads to oxidative damage, which exacerbates diseases and causes a series of pathologies; thus, the exploration of natural antioxidants is increasingly urgent [36]. The aqueous extracts of L. rhinocerotis have good antioxidant activity [37, 38]. Antioxidant experiments, such as the ferric-reducing antioxidant power assay (FRAP), ABTS radical scavenging assay, and DPPH radical scavenging assay, were used to evaluate the antioxidant activity of various extracts [39]. For the ABTS and DPPH assays, the scavenging capacities of aqueous extracts of LRW and LRS were lower than that of LRR, which revealed that LRS has a stronger antioxidant activity. In the FRAP assay, LRW had the strongest FRAP scavenging capacity (7.37 ± 0.18 μg AAE/mg of DAE). This may be related to the high content of total polyphenols and flavonoids. The mechanisms of the inhibition of redox reactions by antioxidant ingredients are different, such as producing superoxide anions, facilitating metal ion chelation, and promoting free radical chain reactions. 5. Conclusions In this study, the differences between cultivated and wild L. rhinocerotis were elucidated. Both cultivated and wild L. rhinocerotis are abundant in bioactive components, and they both have antioxidant activities. This is the first time that metabolomics analysis has been applied to the study of L. rhinocerotis quality and the LRR, LRS, and LRW can be discriminated by untargeted metabolite profiling. In the antipulmonary injury experiments, the results suggested that wild L. rhinocerotis was more effective than cultivated. Moreover, PLRW plays an anti-inflammatory and antiapoptotic role in LPS-induced MRC-5 injury. PLRW may defend against cell damage by activating the NLRP3/caspase-1 pathway. In summary, both cultivated and wild L. rhinocerotis are abundant in bioactive components and have antioxidant and anti-inflammatory activities. Acknowledgments This work was supported by the project of the National Survey of Traditional Chinese Medicine Resources (project no. GZY-KJS-2018-004) from the National Administration of Traditional Chinese Medicine, the fund for improving medical service and security capacity of the department of social security, Ministry of Finance (Grant no. (2019)39), and Guangdong provincial rural revitalization strategy special project—Guangdong Modern Southern Medicine Industry Technology System Innovation Team (2020KJ148). Abbreviations L. rhinocerotis: Lignosus rhinocerotis LRR: Lignosus rhinocerotis cultivated in rice medium LRW: Lignosus rhinocerotis cultivated in wild LRS: Lignosus rhinocerotis cultivated in sawdust medium PLRR: The polysaccharides of Lignosus rhinocerotis cultivated in rice medium PLRW: The polysaccharides of Lignosus rhinocerotis cultivated in wild PLRS: The polysaccharides of Lignosus rhinocerotis cultivated in sawdust medium.

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Was goofing off while i was putting my ethanol extraction rig, away for easter, my “studio” does have a real function when family visits 😁😅. It got me thinking about how the magnetically attached keyboard/cover, by breaking the connection, the ipad slid gently to the floor, after falling from teetering tripod (next video short is aftermath

Cited paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982118/ Major depressive disorder, also known as depression, is a common neuropsychiatric disorder that affects more than 300 million people of all ages [1] and is one of the leading causes of global disease burden [2]. The common signs and symptoms of depression include loss of interest in daily activities, difficulty concentrating and making decisions, fatigue, sleep problems, overeating or appetite loss, pessimism, hopelessness, persistent sadness, and restlessness [3,4]. Hericium erinaceus is a medicinal-culinary mushroom widely found in East Asian countries and is commonly known as lion’s mane mushroom, Yamabushitake, or monkey’s head mushroom [17]. Hericium erinaceus has a long history as a medicine [17] and has been found to promote positive nerve and brain health. It has great potential in treating neurological disorders as it contains neurotrophic compounds that can pass through the blood–brain barrier [18,19]. Bioactive compounds extracted from its fruiting body or mycelium (Figure 1) have been demonstrated to possess antioxidative [20], antidiabetic [21], anticancer [22,23], anti-inflammatory [24], antimicrobial [23], antihyperglycemic [25], and hypolipidemic properties [26]. Moreover, H. erinaceus has been used to treat cognitive impairments [27], Alzheimer’s disease [28], Parkinson’s disease [29], ischemic stroke [30], and presbycusis [14]. Recently, the present research on H. erinaceus has been focused on its antidepressant-like effects for the treatment of depressive disorder [31,32,33]. Amycenone is an H. erinaceus extract that obtained from the fruiting body through a patented process, which contains 0.5% hericenone and 6% amyloban [73]. In 2015, Yao et al. reported the antidepressant-like and anti-inflammatory effects of amycenone in an animal model of depression with LPS-induced inflammation [33]. A recent study by Chiu et al. (2018) investigated the effects of extracts of H. erinaceus enriched in Erinacine A (5) in an animal model of depression induced by repeated restraint stress [31]. They found that bioactive compounds extracted from the mycelium of H. erinaceus by ethanolic extraction were enriched with erinacine A, which is believed to induce neurogenesis. Recently, a clinical study examined the effects of H. erinaceus on anxiety, depression, binge eating, and sleep disorders in 77 volunteers with a body mass index (BMI) ≥ 25 kg/m2 and an average age of 53.2 [80]. The study recruited overweight or obese participants positive for one or more administered tests, including Zung’s Depression Self-Assessment Scale, Zung’s Anxiety Self-Assessment Scale, Symptom Checklist-90, and the binge eating scale (BES). Participants in the H. erinaceus intervention group received three capsules containing 80% mycelium extract and 20% fruiting body extract daily for 8 weeks. They found that H. erinaceus significantly reduced depression and anxiety, as well as improvement on sleep disorders after 8 weeks of oral administration. The observation was linked to an increase in peripheral pro-BDNF and in the pro-BDNF/BDNF ratio. Hericenones are aromatic compounds extracted from the fruiting body of H. erinaceus. There are 11 hericenones (hericenones A-K) that have been identified, of which four (hericenones C (1), D (2), E (3), and H (4) (Figure 3)) have been reported to promote NGF synthesis in mouse astrocytoma cells

Cited paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8887958/ A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19 After a bout of mispronunciation, we get some idea that… This Advocacy for mushroom vape could be prophylactic for various virus’ my blend each mushroom is mentioned … So… for dodging Covid-19 I advocate my 6-mushroom blend vape…

a Video of Paul Stamets, whose Hard work just saved ecology as we ever known it. Without Paul Stamets research and Adamant stance on how Mushrooms benefit, we would not be in the position of providing Mushroom Vape as a medicinal supplement… the atomization of mushrooms in a vapor ingested by the lungs… we need to heal ourselves, the bees needed to heal themselves, by the same activity, Paul Stamets, saved the Human Species, For we, by extension, are Paul Stamets’ Bees Advocacy for Vape

Cited https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394315/ My difficulty for pronouncing Mycological and organic chemistry terms should not detract from the importance of anti bacterial ans anti viral properties of Fomitopsis officinalis Agarikon.

Cited works https://www.huffpost.com/entry/agarikon-mushroom_b_1861947 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674418/ Again sorry for talking with marbles in mah mouth, 😁 in this Video I’d like to introduce to the viewer Paul Stamets And the wonderful potential that is Agarikon in medicinal supplement And as 1/6 of my 6-mushroom blend vape “juice”

Cited articles https://pubmed.ncbi.nlm.nih.gov/33822495/ https://reset.me/story/chaga-mushroom-a-traditional-folk-medicine/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142110/ https://pubmed.ncbi.nlm.nih.gov/29800742/ https://pubmed.ncbi.nlm.nih.gov/34195023/ The most important take away is that as far back as: As The word ‘Chaga‘ is derived from the old Russian word for mushroom, from the language of the indigenous people living near the Ural Mountains. In the 12th century, Tsar Vladimir Monomakh, also known as the Grand Prince of Kievan Rus, was widely known as a Chaga enthusiast. Apparently, this ancient Russian leader used these mushrooms to cure his lip cancer. We look at these papers and discuss things like Terpenoids May Interfere with SARS-CoV-2 As an antiseptic To treat digestive disorders such as ulcers To prevent illnesses of the heart and liver To expel parasites Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B) characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells Sure these are the titles of the papers and or highlighted parts, yet, it is quite interesting, and I would like to have uncovered more for follow up videos, as it stands I hac\ve recorded this three times perhaps I can upload one or two of these as a filler… the same information perhaps… Identical description as on youtube

Cited paper COVID-19 and Cancer Diseases—The Potential of Coriolus versicolor Mushroom to Combat Global Health Challenges Major copy paste Go to: 4. Effect of CV Extract on Viral Infections Among the bioactive properties of compounds derived from CV, their anti-viral activity against numerous viruses is well described. The high therapeutic index of CV extract was discovered against herpes simplex virus (HSV) type 1 and HSV type 2 in the experiments conducted on the kidney epithelial cells in vitro (EC50 = 77 µg/mL measured for the both HSV types) [75]. Liu et al. revealed that PSK can inhibit Epstein–Barr virus (EBV)-infected B and T cells and activate natural killer (NK) cells [76]. It has also been reported that PSP has an inhibitory effect against human immunodeficiency virus (HIV) type l reverse transcriptase and protease that are two enzymes of paramount importance to the life cycle of HIV (IC50 = 150 μg/mL and IC50 = 6.25 μg/mL measured for the interaction between HIV-1 gp120 and immobilized CD4 receptor and for the potent inhibition of recombinant HIV-1 reverse transcriptase, respectively) [77]. Rodriguez-Valentín et al. observed that PSP exerts an anti-HIV activity mediated by TLR4 and promotes the upregulation of specific anti-viral chemokines (RANTES, MIP-1) and stromal cell-derived factor 1 (SDF-1α)) known to block HIV-1 co-receptors [78]. Furthermore, oral administration of β-glucans from CV improves survival and reduces lung viral titers and weight loss in chickens and mice infected with the influenza virus [21]. CV-based vaginal gel is also available for treating women with cervical uterine high-risk human papillomavirus (HPV) infection [79,80]. Second major cut and paste Hetland et al. believe that CV may be utilized directly against SARS-CoV-2 infection as well as to prevent the immunological overreaction and harmful inflammation associated with COVID-19 [84]. According to Saxe, who is leading the MACH-19 (Mushrooms and Chinese Herbs for COVID-19) ongoing clinical trials approved by the Food and Drug Administration (FDA), the combination of CV with another fungus–agarikon (Fomitopsis officinalis) offers physiologically plausible immunomodulating capabilities against SARS-CoV-2 through the interaction with T lymphocyte receptors [85]. Rangsinth et al. examined 36 mushroom-derived bioactive compounds that potentially serve as the inhibitors of SARS-CoV-2 main protease. Indeed, 25 of 36 candidate compounds displayed the potential to inhibit this main viral protease. The most promising seems to be a betulinic acid derived from CV [86]. Third major cut and paste This mushroom shows a wide spectrum of benefits, which may be useful in combating modern medical challenges. Herein, we have presented data determining the proof of strong anti-viral, anti-inflammatory, anti-oxidative, and immunostimulating properties of CV. Simultaneously, other reports confirmed the impressive anti-cancer response of CV extract and its compounds directed towards wide range of cancer types and revealed the molecular background of this process. By induction of different cell death modalities, such as apoptosis or necroptosis, CV extract appears to be an effective adjuvant therapy. Moreover, analysis of other reports revealed that CV also affects fever, the innate immunity mechanism beneficial for both cancer and viral infections recovery. Thank you for watching @acerb8