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Secrets of Blue Zones: Longevity, Lifestyle, and Healthspan
Join Dr. Sanjeev Goel and Dr. Anil Maheshwari in this discussion as they explore the fascinating concept of Blue Zones and the secrets to longevity shared by these unique communities. Discover key takeaways on physical activity, dietary choices, alcohol consumption, community bonds, family relationships, mental and social engagement, and effective time management for a healthier, more fulfilling life. Gain valuable insights into the genetics versus environment debate in longevity and learn how to adapt these lessons to our modern, bustling lives. Don't miss this opportunity to enhance your health span and well-being.
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TIMESTAMP:
00:00 - Intro
03:13 - Genetics vs. Environment
05:04 - The Five Blue Zones
06:57 - Move Naturally
10:01 - Purpose in Life
14:09 - Downshift and stress reduction
16:46 - Importance of sleep and quality of life
17:34 - Healthy Lifestyle Factors
18:40 - The Importance of Physical Activity
19:37 - Impact of Work Activity on Daily Steps
21:47 - The 80% Rule and Eating Habits
24:11 - Dietary Habits in Blue Zones
25:02 - Belonging to a Faith-Based Community
26:15 - Importance of Belief and Serving Others
28:42 - Belonging and Serving in Faith Communities
30:15 - Extended Family and Relationships
31:35 - Close Friendships and Social Networks
32:57 - Learning from the Seventh-Day Adventists
35:18 - Time Management and Activity Integration
36:03 - Importance of Saying No
36:34 - Designing Healthy Societies
37:40 - Blue Zone Initiatives in Cities
39:34 - Impact of Blue Zone Initiatives
40:29 - Genetics in Longevity
41:15 - Caloric Restriction and Diet
42:01 - Benefits of Fresh Olive Oil
43:13 - Greek Coffee and Health
44:08 - High Rates of Smokers in Blue Zones
44:45 - Genetics, Smoking, and Longevity
45:40 - Genetics and Longevity
46:56 - Different Genes and Longevity
47:57 - Switching to Vaping and Health
48:28 - Genetics in Blue Zones
49:32 - The Role of Environment
50:27 - Identifying Blue Zone Communities
51:05 - Closing
Blue Zones longevity:
Explore Blue Zones for insights on living longer.
Learn from regions with exceptional longevity.
Adopt habits from Blue Zones for a healthier life.
Discover factors influencing Blue Zones' longevity.
Improve your longevity with Blue Zones' wisdom.
Factors for longevity:
Longevity depends on genes and lifestyle.
Understand key factors for a longer life.
Lifestyle choices impact your lifespan.
Genes and habits determine longevity.
Enhance well-being by addressing longevity factors.
Physical activity and health:
Stay active for a healthier life.
Walk and move for longevity.
Active routines boost well-being.
Exercise supports heart health.
Prioritize physical activity for longevity.
Diet and longevity:
Plant-based diets promote longevity.
Eat mindfully for a longer life.
Choose whole foods for health.
Balance your diet for longevity.
Nutrient-rich foods enhance well-being.
Genetics vs. environment in longevity:
Environment plays a key role in longevity.
Lifestyle outweighs genetics in some cases.
Blue Zones emphasize environmental factors.
Healthy choices counter genetic risks.
Balance genes and habits for a longer life.
Proper nutrition is a cornerstone of Longevity Medicine, with diets like the Mediterranean diet showing promising results in promoting health.
#BlueZonesLongevity #HealthyLifestyle #LongevitySecrets
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Blue Zones - Longevity - Genetics vs Environment? The Danish Twin Studies. #bluezones #longevity
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Blue Zones - Riding Horses At 100. #bluezones #longevity #longevityscience
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11
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Blue Zones - Importance of a Sense of Purpose #bluezones #peakhuman #longevity
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The Israel-Gaza Conflict: Understanding Moral Distinctions and Global Dynamics | 2 Guys with Mics
In this episode of 2 Guys with Mics, hosts Dr. Sanjeev Goel and Neeraj Jain discuss the Israel-Gaza conflict, moral distinctions between parties, and hope for a ceasefire. They also explore AI risks, challenge conventional beliefs about ancient civilizations in North America, and briefly mention Taylor Swift's documentary success. The hosts conclude by sharing their thoughts on the immersive concert experience in the "sphere" and its impact on the future of entertainment.
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TIMESTAMP:
00:00 - Introduction
03:45 - Reactions to Israel and Gaza Situation
06:25 - Sam Harris' Perspective on Moral Equivalence
09:10 - Dealing with Opponent's Different Values
11:20 - Failed Policies and Political Factors
13:10 - Importance of Independent Journalism
14:30 - LGBTQ Community's Support for Palestine
16:16 - AI and its control
17:05 - AI's capability to rewrite its own software
18:03 - "Rewind" software's capabilities
19:27 - AI predicting human behavior
21:11 - AI's potential impact on elections
22:03 - Discovery of ancient footprints in North America
24:20 - Reevaluating historical timelines and civilizations
25:08 - Time perception and history
27:04 - Taylor Swift's documentary success
29:16 - Impact of immersive experiences on entertainment
31:12 - Setting a new standard for entertainment
32:02 - Closing remarks
Israel-Gaza conflict:
The Israel-Gaza conflict has been a long-standing and complex issue in the Middle East.
Recent events in the Israel-Gaza conflict have garnered international attention.
Efforts to broker a ceasefire in the Israel-Gaza conflict have faced significant challenges.
Understanding the historical context is crucial when discussing the Israel-Gaza conflict.
Media coverage plays a vital role in shaping public perception of the Israel-Gaza conflict.
AI risks:
AI risks encompass concerns about the potential misuse of artificial intelligence technologies.
Ethical considerations are essential in mitigating AI risks.
The rapid advancement of AI technology raises questions about its long-term implications and risks.
Experts are working to develop safeguards to minimize AI risks.
Public awareness about AI risks is increasing as AI becomes more integrated into our lives.
Ancient civilizations:
The study of ancient civilizations provides insights into human history and cultural evolution.
Archaeological discoveries continue to uncover the mysteries of ancient civilizations.
Ancient civilizations like the Egyptians, Greeks, and Romans have left a lasting legacy.
The decline of ancient civilizations often resulted from a combination of factors.
Learning from the achievements and mistakes of ancient civilizations can inform our modern societies.
Taylor Swift documentary:
Taylor Swift's documentary offers an intimate look into her life and career.
The Taylor Swift documentary explores the challenges and triumphs of a superstar.
Fans eagerly awaited the release of Taylor Swift's documentary.
The documentary provides a behind-the-scenes perspective on the music industry.
Taylor Swift's documentary has been praised for its authenticity and storytelling.
Future of entertainment:
The future of entertainment is increasingly driven by technology and innovation.
Virtual reality and augmented reality are shaping the future of entertainment experiences.
Streaming platforms are revolutionizing the way we consume entertainment content.
The future of entertainment may include interactive and immersive experiences.
Content creators and artists are adapting to changing trends in the future of entertainment.
Longevity Medicine represents a paradigm shift in healthcare, offering hope for a healthier and longer life for individuals worldwide. Its continued development and integration into healthcare systems hold promise for a future where aging is not a burden but a journey of vitality and well-being.
#IsraelGazaConflict #MoralDistinctions #GlobalDynamics
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How Creatine Works #creatinebenefits #creatine #peakhuman
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Ultimate Guide to Creatine Supplements
Join Dr. Sanjeev Goel and Carmelia in this video as they explore the benefits of creatine supplementation for muscle growth and performance. They discuss its origins, muscle-strengthening effects, recommended dosages, and the importance of taking it with carbohydrates and protein. They also address concerns about its safety and suitability for vegetarians. Subscribe, comment, and visit Peak Human's website for more insights and support.
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TIMESTAMP:
00:00 - Introduction
00:15 - What Is Creatine?
01:00 - Natural Production and Dietary Sources
01:59 - Vegetarian Considerations
03:00 - Forms of Creatine
03:45 - Loading and Maintenance Doses
05:00 - Taking Creatine with Pre-Workout
06:15 - Creatine with Carbohydrates and Protein
07:05 - Safety and Kidney Concerns
08:15 - Benefits of Creatine
10:00 - Muscle Building and Fat Reduction
11:00 - Vegetarians and Creatine
12:00 - Recommended Dosage
13:00 - Conclusion
Creatine:
Creatine boosts exercise performance.
Found in meat, it's essential for vegetarians.
Improves muscle strength and mass.
Safe and widely used by athletes.
Enhances energy production in cells.
Muscle strength:
Vital for daily activities and fitness.
Resistance training builds muscle strength.
Reduces injury risk and boosts performance.
Balanced workouts target all muscle groups.
Diet with adequate protein supports strength.
Supplement:
Supplements provide missing nutrients.
Include vitamins, minerals, and protein.
Consult a healthcare professional first.
Supplements complement but don't replace food.
Research products before using them.
Vegetarian:
Vegetarian diets exclude meat.
Rely on plant-based protein sources.
Chosen for health, ethics, or environment.
Careful planning ensures nutritional needs are met.
Variations include vegan, lacto-ovo, and more.
Protein synthesis:
Cells use amino acids to create proteins.
Crucial for muscle repair and growth.
Resistance training and protein intake stimulate it.
Proper nutrition supports efficient synthesis.
Key for muscle recovery after exercise.
Longevity medicine places a strong emphasis on maintaining cognitive function in later life through brain training, neuroprotective supplements, and lifestyle choices.
#creatine #musclegrowth #nutritionalsupplements
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views
Creatine with Protein or Carbs? #creatine #musclegrowth #creatinebenefits
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6
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How to take Creatine - the muscle building supplement #creatine #creatinemonohydrate #muscle
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AKG the longevity supplement. #akg #longevityscience #antiaging
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AKG Longevity & Healthspan. #akg #longevityscience #supplements #peakhuman
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The Amyloid Precursor Protein. #alzheimers #app #amyloid
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The Amyloid Cascade in Alzheimer's #peakhuman #alzheimers #amyloid
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Ultimate Solution for Women's Pelvic Floor Health and Pleasure | Emsella Treatment
In this video, they introduce a groundbreaking treatment called Emsella, designed to improve women's pelvic floor health and sexual function. Emsella uses electromagnetic stimulation for non-invasive strengthening of pelvic floor muscles. The treatment offers benefits for urinary incontinence and sexual dysfunction in women, and it may also benefit men. Childbirth and aging can weaken the pelvic floor, and Emsella provides a non-surgical solution. They encourage open discussions about pelvic health and offer information on how to get in touch for appointments. Don't forget to like and subscribe for more valuable content.
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Pelvic Floor Treatment:
Pelvic floor treatment is popular for improving pelvic health.
Effective for issues like urinary incontinence.
Non-invasive and safe option.
Can enhance quality of life.
Consider it for pelvic floor issues.
Esmella Treatment:
Uses magnetic stimulation for pelvic health.
Enhances sexual pleasure, alleviates incontinence.
Promising non-surgical solution.
Offered at Peak Human Labs.
Explore benefits on their website.
Urinary Incontinence:
Common issue, especially in women.
Impactful and embarrassing condition.
Pelvic floor treatment helps manage it.
Seek treatment for improved confidence.
Don't let it hold you back.
Sexual Dysfunction:
Affects both genders, diminishes satisfaction.
Esmella therapy may provide relief.
Crucial to address for a healthy sex life.
Consult healthcare provider for solutions.
Seek help when experiencing sexual dysfunction.
Kegel Exercises:
Strengthen pelvic floor with Kegel exercises.
Recommended for pelvic health in women.
Convenient and discreet exercises.
Men can benefit too for improved sexual function.
Enhance bladder control and sexual experiences with regular Kegels.
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******************
TIMESTAMP:
0:00 - Introduction
1:00 - Benefits of Emsella for Urinary Incontinence
1:43 - Benefits of Emsella for Sexual Function
3:00 - Emsella's Effectiveness in Men
5:00 - Impact of Childbirth on Pelvic Floor
8:00 - How Emsella Treatment Works
9:30 - Positioning for Treatment
11:00 - Monitoring and Maintenance
13:00 - Effect on Vaginal Tightening
14:20 - Conclusion
#PelvicHealth #EsmellaTreatment #UrinaryIncontinence
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Secrets of Longevity with Alpha Ketoglutarate
In this video, Dr. Sanjeev Goel discusses Alpha Ketoglutarate (AKG), a promising longevity molecule found in their supplement, Fasting Pro. AKG is essential for energy production within cells and has shown positive effects on lifespan, DNA age, stem cell renewal, skin, gut, and bone health in various studies. Notably, post-menopausal women experienced a 1.6% increase in bone density with AKG supplementation. However, the optimal dosage is still being researched. Dr. Sanjeev recommends their supplement as a safe source of AKG.
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********************
Alpha Ketoglutarate (AKG):
AKG is a vital metabolic compound.
It's researched for potential health benefits.
May promote longevity and overall health.
Crucial for energy production and amino acids.
Found in the Fasting Pro supplement.
Longevity Molecules:
Studied for extending lifespan.
Vital for healthy aging research.
AKG is one promising longevity molecule.
Often tested on various organisms.
Key to improving healthspan.
Cellular Respiration:
Powers cells through nutrient breakdown.
AKG plays a role in cellular respiration.
Vital for overall cellular functions.
Optimizing it is crucial for health.
AKG's role is studied in longevity research.
DNA Methylation:
Regulates gene expression.
Impacts aging and health.
AKG may affect DNA methylation.
Important in understanding AKG's benefits.
Linked to aging processes.
Fasting Pro Supplement:
Contains AKG for health support.
Offers a convenient AKG source.
Aims to promote overall health.
Gaining popularity for wellness.
Investigating AKG's effects on health.
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******************
TIMESTAMP
00:00 - Intro
00:18 - AKG's Importance in Cellular Functions
01:57 - Research Findings in Different Organisms
03:28 - Human Studies and Potential Benefits
04:08 - Dosage and Supplement Availability
04:25 - Conclusion and Future Research
#AlphaKetoglutarate #LongevityMolecules #CellularRespiration
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Amyloid Beta Deposition
Ever wondered what causes dementia? 🤔 Approximately 70% of cases are linked to amyloid deposition. 🧠 Amyloid is formed when a protein called APP is broken down.
In the full video, I dive deeper into the science behind amyloid beta deposition. 👨⚕️
Understanding the causes can lead to better prevention and treatment strategies.
.
.
.
#DementiaAwareness #AlzheimersResearch #Neuroscience #PeakHumanLabs #BattleAgainstAlz #AlzAwareness #BrainHealth #Amyloid #AmyloidDeposition #Dementia
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The Science Behind Amyloid Beta Deposition | Alzheimer's Disease
In this video, join Dr. Sanjeev Goel as he delves into the fascinating science behind amyloid beta deposition and its connection to Alzheimer's disease. Discover the historical origins of Alzheimer's research, the role of genetic mutations in amyloid buildup, and the intricate cascade of events that lead to neuroinflammation and cognitive decline.
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Alzheimer's disease:
Alzheimer's is a memory-related disease with no cure.
Risk factors include family history and age.
Ongoing research seeks better treatments.
Alzheimer's affects patients and caregivers deeply.
Early diagnosis aids symptom management.
Amyloid beta deposition:
Amyloid beta buildup marks Alzheimer's.
Imaging detects amyloid plaques.
Understanding helps treatment development.
Researchers target prevention strategies.
Reducing amyloid buildup is vital.
Genetic mutations:
Mutations increase Alzheimer's risk.
Inherited mutations raise the risk.
Genetic counseling assesses risk.
Research explores treatment targets.
Alzheimer's may have genetic links.
Neuroinflammation:
Neuroinflammation harms the nervous system.
It's linked to Alzheimer's and other diseases.
Microglia activation drives inflammation.
Lifestyle affects neuroinflammation levels.
Reducing inflammation may slow disease.
Blood test for Alzheimer's:
FDA-approved blood test aids early diagnosis.
Measures amyloid beta ratios in plasma.
High amyloid beta 42 ratio raises risk.
Convenient testing assesses Alzheimer's risk.
Early detection enables timely interventions.
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00:00 - Introduction
00:23 - Historical Background
01:12 - Amyloid Beta Buildup
02:25 - Genetic Mutations
03:41 - Early Signs of Amyloid Deposition
04:59 - The Amyloid Cascade
#alzheimersdisease #geneticmutation #amyloidbetadeposition
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Insights on Trudeau's Blunders, AI in Elections, and OIC's Weight Loss Impact | 2 Guys with Mics
In this video, join Dr. Sanjeev Goel and Neeraj Jain for a diverse range of topics in this episode of 2 Guys with Mics.
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From Trudeau's blunders affecting Canada's reputation to India's use of propaganda against Canada and managing international relations. We dive into AI's role in future elections, Elon Musk's Neuralink project, animal testing concerns, and the animal rights movement. Plus, we discuss effective altruism and its alignment with promoting vegetarianism. The episode wraps up with insights into the UAW strike and President Biden's support for the union. Don't miss out on this diverse and thought-provoking discussion! Tune in for more!
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0:00 - Intro
1:04 - Comparison of AI and human creativity
1:52 - Canada's reputation on the international stage
2:09 - India's actions against Canada
3:16 - Discussion about creating and refuting fake news
3:45 - Mention of AI's potential in creating fake content
4:07 - Mention of Elon Musk's company, Neuralink
6:02 - Comparing human and AI creativity in a study
7:27 - Discussion about AI's predictive capabilities
7:40 - Elon Musk's approach to AI and Neuralink
8:02 - Discussion about Neuralink's monkey testing
9:15 - Concerns about animal testing
10:11 - Discussion about animal rights activism and effectiveness
11:19 - Discussion about the disconnect between people and animal agriculture
12:09 - Mention of Halal and Kosher practices
13:28 - Speculation on the future of animal rights
15:17 - Discussion about promoting vegetarianism
17:05 - Mention of effective altruism and its connection to vegetarianism
17:32 - Discussing unions and wage issues.
18:03 - Talking about teachers' unions and their impact.
19:00 - Discussing the United Auto Workers and concessions.
20:01 - Talking about the CEO-worker wage gap.
21:04 - Continuing the discussion on unions and profit-sharing.
22:26 - Mentioning the potential government shutdown.
23:07 - Discussing the impact of a government shutdown.
25:13 - Talking about the availability of a weight loss medication (OIC).
26:00 - Mentioning the gray market for weight loss medication.
27:05 - Discussing the potential reasons behind medication shortages.
28:05 - Talking about the implications of OIC(ozempic pen injector) availability.
29:12 - Mentioning the lack of questions asked at social gatherings.
30:12 - Discussing social media's potential impact on egotism.
32:05 - Talking about the importance of asking questions in conversations.
34:39 - Closing
#TrudeausBlunders #AIinElections #OICWeightLossImpact
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The cruelty of Factory Farming #factoryfarming #animalrights
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Are you disconnected from Meat? #meat #vegan #factoryfarming
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4
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Ozempic changes Body Positivity #peakhuman #obesity #bodypositivity
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6
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Teacher Unions #teachers #unions #labour
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7
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Why the Obesity Cards are stacked against the Poor? #obesity #poverty #foodsecurity
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New Biologic Age Clock Revealed by Dr. Varun Dwaraka
In this video, Dr. Sanjeev Goel and Dr. Varun Dwaraka, Head of Bioinformatics at TruDiagnostic, discuss biologic age testing, focusing on DNA methylation and epigenetics.
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They explore how epigenetic changes occur with aging, affecting gene expression. The conversation touches on the history of epigenetic clocks, aiming to predict biological age beyond chronological age. They introduce the DunedinPACE Clock, which shows promise in improving accuracy. TruDiagnostic's OM Clock integrates various data layers, providing a comprehensive aging assessment. It predicts health outcomes with higher sensitivity and specificity than existing clocks and undergoes ongoing research for response to interventions. For more details, visit www.trudiagnostic.com or connect with Dr. Varun Dwaraka on LinkedIn or Instagram.
Varun Dwaraka PhD is the Head of Bioinformatics at TruDiagnostic, and an aging and longevity investigator specializing in epigenetics and bioinformatics. He has co-authored numerous publications relating to genetics, epigenetic clocks, DNA methylation, and tissue regeneration. In 2020, Dr. Dwaraka was elected as a full member to the Sigma Xi, The Scientific Research Honor Society, and currently serves as a 2023 Foresight Fellow in Biotechnology and Health Expansion, awarded by the Foresight Institute. He also serves on the Scientific Advisory Board for SRW Labs based in New Zealand, offering insight into the application and interpretation of epigenetic age biomarkers. Dr. Dwaraka is passionate about implementing machine learning methods to advance predictive medicine, identify novel biomarkers, and create algorithms to better understand the biologyofaging.
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0:00 - Intro
2:08 - Dr. Varun discusses the history of epigenetic clocks.
3:03 - Dr. Varun explains DNA methylation.
5:33 - Discussion about the effects of DNA methylation on gene expression.
8:24 - Dr. Varun talks about changes in methylation patterns with age.
9:00 - Introduction to Dr. Steven Horvath's work on epigenetic clocks.
10:14 - Dr. Horvath's role in the development of epigenetic clocks.
11:03 - The limitation of predicting chronological age accurately.
13:05 - DunedinPace Clock and its significance.
15:17 - Pace of Aging score.
15:33 - Explaining the concept of the Pace of Aging score.
16:10 - Describing the bounds of the Pace of Aging score.
17:00 - Question about the validity and frequency of the Pace of Aging score.
18:05 - Discussing how quickly the Pace of Aging score can change.
19:25 - Speculating on the reduced risk of mortality.
21:02 - Discussing variations in methylation patterns between tissues.
23:11 - Mention of the commonality and differences between aging clocks.
24:04 - Comparison of shared CpGs between different aging clocks.
25:26 - Discussion of differences in CpGs selected by different clocks.
26:06 - Question about similarities in aging CpGs across different species.
27:00 - Mention of a mammal clock that is conserved across species.
28:25 - Introduction to the development of the Omic Clock by True Diagnostic.
29:57 - Partnership with Brigham and Women's Hospital for data collection.
30:14 - Idea of combining different layers for a multi-omic inferred clock.
31:22 - Elastic net regression to identify relevant phenotypes.
31:49 - Training to predict time until death.
32:21 - Identification of factors associated with increasing EMR age.
33:03 - Incorporating additional data such as proteins, clinical values, and metabolites.
33:57 - Mention of generating EMR age.
34:03 - Integration of various data types into the clock.
35:00 - Creation of models to predict proteins, clinical values, and metabolites.
36:02 - Reducing the number of models to focus on relevant features.
37:01 - Explanation of correlation and filtering based on correlation values.
38:01 - Introduction of the "omic age" and its importance.
39:36 - Discussion of the omic age and its association with diseases.
40:00 - Explanation of odds ratios and their significance.
42:15 - Comparison of different clocks in terms of sensitivity and specificity.
43:05 - Mention of future testing of interventions on omic age.
#Epigenetics #BiologicAgeClock #Aging
138
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Cocaine on the Plane??? #fakenews #propaganda #trudeau #india
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