Cancer reactivation
Professor Angus Dalgleish, MD, FRCP, FRCPA, FRCPath, FMedSci
Clinical consultant treating melanoma
Heat killed mycobacteria to boost immune system, INM101
Endemic vitamin D in the UK, if this is improved, immunotherapy also improves.
5 – 20 year stable melanoma patient relapsing
Melanomas often activated after extreme stress, divorce, bereavement etc.
Now seeing more melanoma relapse, but these patients did not have life trauma, but they had been boosted.
In the group getting melanoma relapses, they all mentioned they were up to date with covid boosters.
Could it be the boosters that were leading to the relapse.
After 30 years of vaccine work and research, focus on antibodies is misguided, T cells are more important.
Innate T cell activity goes down after age of 55, in your boots by age 70
As innate T cell function goes down cancers increase
So, does the decline in innate T cell activity causse’ the increase in cancer
Heat killed mycobacterial vaccine boosts this immune response.
If you keep giving killed mycobacterium, it does not induce antibodies, just keeps boosting T cells.
Also seems to protect against colds and flu by boosting immune response.
PD predicted this would be a good front line for covid.
At the height of the first wave, none of the patients on mycobacteria vaccine caught covid, eval although they had advanced melanoma. Staff were getting ill, none of the vulnerable patients got sick with covid.
In general, if you need to give more than 2 shots of vaccine, it doesn’t work.
Vaccines should be given to people with known immune status.
If you don’t need a vaccine it will make things worse.
You only have a limited capacity in your immune system.
If you boost with another vaccine, to harness half of the immune system to make antibodies, to a virus, which no longer exists on the planet.
Then you will weaken the immune system.
Confirmed by science, after booster you no longer make IgG 1 and 3 neutralising antibodies, you make IgG4
Boosters also suppress the T cell response.
T cell response crashes after the booster in cancer patients, not in all but many of these patients.
T cells control melanoma, relapses only occurred when there was T cell perturbation. Boosters cause perturbation. (First 11 minutes)
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Explosive cancers
Professor Angus Dalgleish is seeing reactivations of stable cancers after covid vaccination
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Pfizer vaccine manufacture
Two different manafacturing processes. Pfizer covid vaccines for the clinical trials were mostly produced using manufacturing ‘process 1’ whereas the vaccines used for population vaccination were produced using a different ‘process 2’
Interview with Josh Guetzkow PhD
Here is the BMJ link: https://www.bmj.com/content/378/bmj.o1731/rr-2
Josh's handle on X.com is @joshg99 and here is a link to a thread I did on P1 vs. P2: https://x.com/joshg99/status/1658421192326365185
Here is a link to my blog:
https://researchrebel.substack.com/
Here are links to my posts on the Pfizer clinical trial
https://researchrebel.substack.com/p/comirnaty-or-comirnaughty
https://researchrebel.substack.com/p/how-long-did-the-pfizer-covid-vaccine
https://researchrebel.substack.com/p/the-pfizer-vaccine-trial-was-not
https://www.bmj.com/content/378/bmj.o1731/rr-2
https://www.nejm.org/doi/suppl/10.1056/NEJMoa2034577/suppl_file/nejmoa2034577_protocol.pdf
https://twitter.com/joshg99/status/1658421192326365185
https://phmpt.org/wp-content/uploads/2023/04/125742_S1_M5_5351_c4591001-interim-mth6-report-body.pdf
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Pfizer, manufacturing process changed
Here is the BMJ link: https://www.bmj.com/content/378/bmj.o1731/rr-2
X.com is @joshg99 and here is a link to a thread I did on P1 vs. P2: https://x.com/joshg99/status/1658421192326365185
Here is a link to my blog:
https://researchrebel.substack.com/
Here are links to my posts on the Pfizer clinical trial
https://researchrebel.substack.com/p/comirnaty-or-comirnaughty
https://researchrebel.substack.com/p/how-long-did-the-pfizer-covid-vaccine
https://researchrebel.substack.com/p/the-pfizer-vaccine-trial-was-not
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Lockdown evidence weak
Evidence for non-pharmaceutical interventions such as mass lockdowns was weak. Not that you could have guessed that easily at the time from government messaging.
Research and analysis
COVID-19: non-pharmaceutical interventions to reduce transmission
https://www.gov.uk/government/publications/covid-19-non-pharmaceutical-interventions-to-reduce-transmission
28 September 2023
Identify and categorise primary studies that reported on the effectiveness of non-pharmaceutical interventions (NPIs),
implemented in community settings to reduce the transmission of coronavirus (COVID-19) in the UK.
Physical distancing
Surface cleaning
Face coverings
Hand and respiratory hygiene
Ventilation
Measures to identify and isolate those who are infectious or may become infectious,
such as testing and isolation (also known as quarantine)
Measures to reduce the number of contacts,
including lockdown,
settings closures and limitation of social contacts (such as the ‘rule of 6’)
Shielding of the most clinically vulnerable
Travel and border restrictions
Review includes 151 studies (search date: 1 March 2023)
Evidence gap map for NPIs
https://research.ukhsa.gov.uk/evidence-gap-map-npi-and-covid-19/
Only 19 of the 151 studies reported on effectiveness of measures to reduce infection risk at individual level,
of which 14 reported on face coverings.
This suggests that there is an evidence gap for other measures within this category,
such as hand and respiratory hygiene,
ventilation and cleaning
(studies that reported on packages of NPIs were excluded).
Two-thirds of the evidence identified was based on modelling studies (100 out of 151 studies).
There was a lack of experimental studies (2 out of 151 studies)
Individual-level observational studies (22 out of 151 studies).
On measures aimed to reduce infection risk at individual level
The evidence available for this category is therefore likely to be weak, both in terms of study design and potential bias.
Studies reporting on travel and border restrictions
a weak evidence base in terms of study design.
Apart from test and release strategies for which 2 randomised controlled trials (RCTs) were identified,
the body of evidence available on effectiveness of NPIs in the UK provides weak evidence in terms of study design,
as it is mainly based on modelling studies,
ecological studies, (relationship between outcome and exposure at a population level)
mixed-methods studies and qualitative studies.
For future pandemic preparedness
A need to strengthen evaluation of interventions,
and build this into the design and implementation of public health interventions,
and government policies from the start of any future pandemic,
or other public health emergency.
The next steps are to critically appraise and synthesise the evidence identified on the effectiveness of individual NPIs,
implemented in community settings to reduce the transmission of COVID-19 in the UK.
There is also a need to review and assess the evidence on the economic impact of NPIs,
as well as their wider impact, including on mental health and health inequalities.
For future reports
More on harm / benefit analysis
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UK parliament to debate excess deaths
BUT, I suspect very few will turn up. Why will MPs not attent this essential debate???????????????
https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregisteredweeklyinenglandandwalesprovisional/weekending15septemner2023
Week ending 15 September 2023 (Week 37)
Deaths registered in the UK was 11,688, which was 2.9% above the five-year average (330 excess deaths)
https://app.powerbi.com/view?r=eyJrIjoiYmUwNmFhMjYtNGZhYS00NDk2LWFlMTAtOTg0OGNhNmFiNGM0IiwidCI6ImVlNGUxNDk5LTRhMzUtNGIyZS1hZDQ3LTVmM2NmOWRlODY2NiIsImMiOjh9
https://ourworldindata.org/grapher/excess-mortality-p-scores-average-baseline
https://stats.oecd.org/index.aspx?queryid=104676
UK, + 36,316
Hungary, - 3,183
USA, 147,828
Poland, - 456
Australia, + 9,992
Canada, + 3,954
Netherlands, + 9,002
New Zealand, + 2,804
Sweden, - 1,082
Denmark, + 1,895
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Multicultural health
Discussion about multicultural aspect of health care.
The Liger, Rex Soderlund
https://theliger.substack.com/p/understanding-ecological-technology
Wefwafwa’s channel
https://www.youtube.com/@WefwafwaAndrew
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Sinister WHO plans
if you are a citizen or resident of the UK, please sign this petition and spread the word. The deadline to sign is October 3, 2023.
https://petition.parliament.uk/petitions/635904
https://jamesroguski.substack.com/p/an-open-letter-to-world-leaders
http://StopTheAmendments.com
http://ExitTheWHO.org (worldwide)
http://ExitTheWHO.com (USA)
http://ThePeoplesDeclaration.com
http://ScrewTheWHO.com
http://JamesRoguski.substack.com/archive
+1 310-619-3055 (yes - feel free to include my number)
Sincerely,
James Roguski
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Data confirms excess deaths in 2023
Confirmation of excess deaths in 2023 for US, UK, Canada, Australia, NZ, Netherlands, and Denmark. However, deaths are lower than expected in Poland, Hungary, and Sweden.
OECD data
https://stats.oecd.org/index.aspx?queryid=104676
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vacine mRNA in breast milk
Biodistribution of mRNA COVID-19 vaccines in human breast milk
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00366-3/fulltext
Background
Several vulnerable groups, such as pregnant and lactating women, have been excluded from the initial vaccine clinical trials.
The possible passage of the vaccine mRNA to breast milk (BM), resulting in neonatal exposure, was not investigated.
As a result, limited research has been conducted on the systemic distribution of vaccine mRNA during lactation,
and whether it is excreted in human breast milk (BM).
We evaluated if COVID-19 vaccine mRNA is detectable in breast milk after maternal vaccination,
and determined its potential translational activity.
Methods
We collected breast milk samples from 13 lactating, healthy, post-partum women before and after COVID-19 mRNA vaccination.
Vaccine mRNA in whole breast milk and BM extracellular vesicles (EVs) assayed using quantitative Droplet Digital PCR,
and its integrity and translational activity were evaluated.
Findings
Of 13 lactating women receiving the vaccine (20 exposures),
trace mRNA amounts were detected in 10 exposures,
up to 45 hours post-vaccination.
The mRNA was concentrated in the breast milk extracellular vesicles (EVs);
This can be significant as the breast milk extracellular vesicles act as natural LNPs, protecting the mRNA from degradation.
Milk-derived EVs are resistant to proteolysis by gastric and pancreatic secretions and can be readily absorbed by intestinal epithelial cells
However, these EVs neither expressed SARS-COV-2 spike protein,
nor induced its expression in the HT-29 cell line.
However, positive control samples used in concentrations similar to those of BM EVs also failed to induce S protein expression.
Vaccine mRNA integrity was reduced to 12–25% in BM.
Interpretation
Our findings demonstrate that the COVID-19 vaccine mRNA is not confined to the injection site,
but spreads systemically and is packaged into BM EVs.
We believe breastfeeding post-vaccination is safe, especially 48 h after vaccination.
Further investigation is required to determine the minimum amount of mRNA needed to elicit an immune response in newborns
Nevertheless, since the minimum mRNA vaccine dose to elicit an immune reaction in infants <6 months is unknown,
a dialogue between a breastfeeding mother and her healthcare provider should address the benefit/risk considerations of breastfeeding in the first two days after maternal vaccination.
Funding
Department of Pediatrics, NYU-Grossman Long Island School of Medicine.
More detail
The mRNA COVID-19 vaccines comprise lipid nanoparticles (LNPs) that contain mRNA coding the SARS-CoV-2 S protein as the active component.
Relatively little has been reported on the tissue localization of the LNPs after intramuscular administration of the vaccine.
Following intramuscular administration, the vaccine LNPs were rapidly disseminated to several organs
Potential translational activity were not evaluated.
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Vaccine reactions made transparent
The OpenVAERS Project allows browsing and searching of the VAERS reports
https://vaers.hhs.gov
https://vaers.hhs.gov/docs/VAERSDataUseGuide_November2020.pdf
https://openvaers.com
https://www.openvaers.com/covid-data
Guide to Interpreting VAERS Data
https://vaers.hhs.gov/data/dataguide.html
"Underreporting" is one of the main limitations of passive surveillance systems,
including VAERS.
VAERS receives reports for only a small fraction of actual adverse events.
Electronic Support for Public Health–Vaccine Adverse Event Reporting System (ESP:VAERS)
https://digital.ahrq.gov/sites/default/files/docs/publication/r18hs017045-lazarus-final-report-2011.pdf
Less than 0.3% of all adverse drug events,
and 1-13% of serious events are reported to the Food and Drug
Administration (FDA).
Likewise, fewer than 1% of vaccine adverse events are reported.
I would add
Essentially only shows temporal correlations
Covid vaccines in comparison with traditional vaccines and other common drugs
https://docs.google.com/document/d/1KuV9FMkdCZ1hr50J_tvaIwArZnVuHNMUoVXQ1hhub68/edit?pli=1#heading=h.plbt52rt9rop
https://worldcouncilforhealth.org/resources/covid-19-vaccine-pharmacovigilance-report/
https://who-umc.org/vigibase/vigibase-services/
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Canada, the people speak
Canadian National Citizens Inquiry (interim report)
Discussion with Mr Ches Crosbie, National Citizens Inquiry administrator.
Check out the full report on this link
https://nationalcitizensinquiry.ca/commissioners-report/
Surely it is the job of governments to evaluate the nature of the national response to the covid pandemic?
Why have a group of concerned Canadian citizens felt it necessary to make this enquiry and evaluation?
How were the covid vaccines first authorised in Canada?
Its over 2 and a half years later, have the covid vaccines not been approved under the traditional approval process for drugs in Canada?
Is NCI now satisfied that Health Canada has now establish the safety and efficacy of Covid-19 vaccines?
Has HC published transparent strict proof of safety and efficacy of covid vaccines as it has worked through the established Canadian drug approval regulations?
What is the system for reporting adverse vaccine reactions in Canada?
Is this system functional, universally known and easy to use,
does it publish full objective data for individuals to make a vaccination decision based on full informed consent?
https://www.canada.ca/en/public-health/services/diseases/coronavirus-disease-covid-19.html
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Activated vitamin D
Free download John’s textbooks in high res pdf.
https://drjohncampbell.co.uk
Order my Physiology Notes in hard copy if you live in the UK,
https://www.ebay.co.uk/itm/154973392319?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=K6raxMZrQnm&sssrc=2047675&ssuid=&widget_ver=artemis&media=EMAIL
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More covid jabs for all in the US
Updated COVID-19 vaccines are recommended for everyone 6 months and older and will be available by the end of this week
‘Safe and effective’
Estimated hospitalizations prevented per 1,000,000 vaccine doses
12 -17 years
19-95 hospitalizations,
5-19 ICU admissions,
and perhaps one death.
5 – 11 years
16 hospitalizations,
(based on Spring 2023 data)
18 – 49 years
75 hospitalizations,
(based on Spring 2023 data)
Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults
https://pubmed.ncbi.nlm.nih.gov/36055877/
Pfizer vaccines excess risk of serious adverse events
(Higher than placebo baseline)
10.1 per 10,000
101 per 100,000
1,010 per 1,000,000
Moderna vaccines excess risk of serious adverse events
(Higher than placebo baseline)
15.1 per 10,000
151 per 100,000
1,510 per 1,000,000
In Western Australia
https://www.health.wa.gov.au/~/media/Corp/Documents/Health-for/Immunisation/Western-Australia-Vaccine-Safety-Surveillance-Annual-Report-2021.pdf
Total AEFI rate following a COVID-19 vaccine
264.1 per 100,000 doses
2,641 per 1,000,000 doses
https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-ceo-bancel-defends-130-covid-vaccine-price-senate-hearing-2023-03-22/
March 22 Moderna chief executive defended the company's plan to quadruple the price of its COVID-19 vaccine,
$130 per dose
Pfizer last year suggested $110 to $130 per dose.
From FDA to MHRA: are drug regulators for hire?
https://www.bmj.com/content/377/bmj.o1538
Money derived from Industry
US Food and Drug Administration, $3,416,000,000 (2022)
The revolving door
FDA, nine out of 10 of its past commissioners, 2006 to 2019 went on to secure roles linked with pharmaceutical companies
https://www.fda.gov/about-fda/fda-organization/robert-califf
2005 UK, House of Commons’ health committee
Industry funding could lead MHRA, to “lose sight of the need to protect and promote public health above all else as it seeks to win fee income from the companies.”
BMJ investigation (2022)
We found that industry money permeates the globe’s leading regulators,
raising questions about their independence
Sociologist Donald Light, Rowan University, New Jersey
“Like the FDA, the TGA was founded to be an independent institute.
However, being largely funded by fees from the companies whose products it is charged to evaluate is a fundamental conflict of interest,
and a prime example of institutional corruption.”
It is no longer possible for doctors and patients to receive unbiased, rigorous evaluations from drug regulators.
FDA
“It’s the opposite of having a trustworthy organisation independently and rigorously assessing medicines.
They’re not rigorous, they’re not independent, they are selective, and they withhold data.
Doctors and patients must appreciate how deeply and extensively drug regulators can’t be trusted so long as they are captured by industry funding.”
Revisiting financial conflicts of interest in FDA advisory committees
https://pubmed.ncbi.nlm.nih.gov/25199895/
Large study, FDA advisory committee members over 15 years,
those with financial interests solely in the sponsoring firm were more likely to vote in favour of the sponsor’s product.
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The Nuremberg Code
Nuremberg Code (1947)
https://research.unc.edu/human-research-ethics/resources/ccm3_019064/
https://encyclopedia.ushmm.org/content/en/article/the-nuremberg-code
https://encyclopedia.ushmm.org/content/en/article/nazi-medical-experiments
Medical Case: US prosecutor details illegal experiments
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Medical professionals on trial, after war for war crimes and crimes against humanity
Including experiments on prisoners in the camp system.
Doctors and nurses, participated in the killing of physically and mentally impaired Germans
German doctors argued
"Doctors Trial." 1946
Trials of War Criminals before the Nuremberg Military Tribunals under Control Council Law No. 10. Nuremberg October 1946 – April 1949
Their experiments differed little from those conducted before the war by German and American scientists.
No international law or informal statement differentiated between legal and illegal human experimentation.
“Permissible Medical Experiments.”
Washington. U.S. Government Printing Office (n.d.), vol. 2., pp. 181-182.
One
The voluntary consent of the human subject is absolutely essential.
This means that the person involved should have legal capacity to give consent;
should be situated as to be able to exercise free power of choice,
without the intervention of any element of force, fraud, deceit, duress, over-reaching, or other ulterior form of constraint or coercion,
and should have sufficient knowledge and comprehension of the elements of the subject matter involved as to enable him to make an understanding and enlightened decision.
Before the acceptance of an affirmative decision,
subject should know the nature, duration, and purpose of the experiment;
the method and means by which it is to be conducted;
all inconveniences and hazards reasonably to be expected;
and the effects upon his health or person which may possibly come from his participation in the experiment.
The duty and responsibility for ascertaining the quality of the consent rests upon each individual who initiates, directs or engages in the experiment.
It is a personal duty and responsibility which may not be delegated to another with impunity.
Two
The experiment should yield fruitful results for the good of society,
unprocurable by other methods,
and not random and unnecessary in nature.
Three
The experiment should be based on the results of animal experimentation,
a knowledge of the natural history of the disease or other problem,
the anticipated results will justify the performance of the experiment.
Four
The experiment should avoid all unnecessary physical and mental suffering and injury.
Five
No experiment should be conducted where there is an a priori reason to believe that death or disabling injury will occur;
except, perhaps, in those experiments where the experimental physicians also serve as subjects.
Six
The degree of risk should never exceed,
that determined by the humanitarian importance,
of the problem to be solved by the experiment.
Seven
Proper preparations should be made,
and adequate facilities provided,
to protect the experimental subject against even remote possibilities of injury disability or death.
Eight
The experiment should be conducted only by scientifically qualified persons.
The highest degree of skill and care should be required through all stages of the experiment
Nine
During the course of the experiment the human subject should be at liberty to bring the experiment to an end
Ten
During the course of the experiment the scientist in charge must be prepared to terminate the experiment at any stage,
that continuation of the experiment is likely to result in injury, disability, or death to the experimental subject.
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Serious adverse vaccine events
Dr. Joseph Fraiman, Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults
Paper in Vaccine, 31 August 2022.
https://pubmed.ncbi.nlm.nih.gov/36055877/
What stimulated you to carry out this research in the first place, what got you interested in the topic?
You refer to the Brighton Collaboration, what is this and how did this feed in to your thinking?
Brighton Collaboration identified adverse events of special interest following covid vaccinations, what adverse events were identified?
You conducted a secondary analysis of the placebo-controlled, phase III randomized clinical trials of Pfizer and Moderna mRNA COVID-19 vaccines in adults.
Tell us a bit about these trials, is this sort of trial standard in testing new pharmaceuticals?
What is a secondary analysis?
What do you mean by excess risk?
What excess risk did you discover?
Pfizer vaccines excess risk of serious adverse events
10.1 per 10,000
Higher than placebo baseline of 17.6 per 10,000
Is it fair to say that this transposes into one serious adverse event per 990 vaccines?
Moderna vaccines excess risk of serious adverse events
15.1 per 10,000
Higher than placebo baseline of 42.2 per 10,000
Is it fair to say that this transposes into one serious adverse event per 662 vaccines?
Combined RNA covid vaccines excess risk of serious adverse events
12.5 per 10,000
Is it fair to say that this transposes into one serious adverse event per 800 vaccines?
You also gave reanalysis data in terms of risk ratio.
What is risk ratio?
Combined, 1.43
Pfizer trial
Exhibited, 36 % higher risk of serious adverse events in the vaccine group
Risk ratio 1.36
Moderna trial
Exhibited, 6 % higher risk of serious adverse events in the vaccine group
Risk ratio 1.06
Combined
Exhibited, 16 % higher risk of serious adverse events in the vaccine group
Risk ratio 1.16
These risks of harm sound high to me, how does this level of risk compare to other vaccines and treatments?
You suggest a formal harm-benefit analyses, what is this and how would this be done?
What are participant level datasets, are these important.
Did you have access to participant level datasets
The original vaccine papers indicated high levels of efficacy in protecting against infection.
What is the difference between relative and absolute risk?
Were these results presented as relative or absolute risk of infection?
Would it have been useful if the original vaccine trial papers had presented absolute risk as well as relative risk?
FDA
Now using near real time surveillance for vaccine safety.
Is this near real time claim working, are we getting timely data?
Is there a risk of false positives in the FDA data collection, or are false negatives an issue?
Can the FDA safely ignore AESIs that are of minimal clinical significance?
Is the FDA methodology confirming previously known AESIs, or is it missing some?
From where is the FDA collecting data and are the data from all sources pooled to improve the power of the analysis?
Is all data being collected from all 50 States?
Is all FDA data open to independent peer review?
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Excess deaths in richer countries
Our world in data, excess mortality
https://ourworldindata.org/grapher/excess-mortality-p-scores-average-baseline?country=~BIH
Our world in data covid vaccination status
https://ourworldindata.org/coronavirus
Office for health improvement
https://app.powerbi.com/view?r=eyJrIjoiYmUwNmFhMjYtNGZhYS00NDk2LWFlMTAtOTg0OGNhNmFiNGM0IiwidCI6ImVlNGUxNDk5LTRhMzUtNGIyZS1hZDQ3LTVmM2NmOWRlODY2NiIsImMiOjh9
https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregisteredweeklyinenglandandwalesprovisional/weekending25august2023
Week ending 25 August 2023 (Week 34)
England and Wales
10,086 deaths
203 mentioned novel coronavirus
2.0% of all deaths
Of the 203 deaths
67.0% (136 deaths) recorded as underlying cause of death
Deaths registered in the UK
11,522, (4.5% above five-year average)
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September 7, 2023
Trafficking in human beings
All age groups
https://worldcouncilforhealth.org
https://worldcouncilforhealth.substack.com/p/human-trafficking
Sexual exploitation (66% of global revenue)
Labour / servitude
Organ removal
Exponentially growing worldwide, internet,
trafficking of children for online commercial sexual exploitation,
videos and photos,
torture and rape of children,
including toddlers
Methods
Deception
Kidnapping
Coercion and/or force
Violence and torture
Forced to watch abuse of children
Forced injection with drugs
US Department of Homeland Security
https://www.dhs.gov/topics/human-trafficking
Human trafficking is the fastest growing criminal industry in the world.
Annual revenue of US$150 billion (2014)
Second largest criminal enterprise after drugs
Particularly vulnerable
Poverty
Abusive family environment
Displacement during violent conflict
Living under corruption
International (UN) Labour Organization (2022)
https://news.un.org/en/story/2022/09/1126421
50 million humans
One in every 150 people in the world
Over 12 million are children
Sexual exploitation
6.3 million people in situations of forced commercial sexual exploitation on any given day, (2021)
This number includes 1.7 million children in commercial sexual exploitation, (ILO 2022)
https://www.americanbar.org/groups/crsj/publications/human_rights_magazine_home/human_rights_vol37_2010/spring2010/sex_trafficking_and_hiv_aids_a_deadly_junction_for_women_and_girls/
Some survivors report having been forced to engage in sexual intercourse with up to fifty perpetrators in a single day
Children trafficked for sex tourism serve about 1,500 customers per year,
more than half of those children are under the age of 12
https://www.missingkids.org/home
Internet abuse, 2019
Nearly 70 million child sexual abuse files (videos/pictures),
https://protectchildren.ca/en/about-us/
78% of child abuse files involved children under the age of 12,
63% showed children under 8
At any given time, there are 750,000 to over 1 million predators online searching for these files
Forced labour and servitude
https://www.europarl.europa.eu/RegData/etudes/BRIE/2020/659360/EPRS_BRI(2020)659360_EN.pdf
Over 20 million people
Hazardous conditions, mines, fields, factories, homes, construction sites.
Carry heavy loads, exposed to pesticides and other toxins
Work excessive hours, severe weather conditions.
Denigrating treatment, constant risk of violent abuse.
Tens of thousands become ill and die.
https://www.theguardian.com/global-development/2021/feb/12/mars-nestle-and-hershey-to-face-landmark-child-slavery-lawsuit-in-us
Organ and blood harvesting
Numbers uncertain
Reports of it are increasing across the world
Medical and ritual purposes
2017, Daesh (ISIS)
https://www.dni.gov/files/NCTC/documents/jcat/firstresponderstoolbox/First-Responders-Toolbox---International-Partnerships-Among-Public-Health-Private-Sector-and-Law.pdf
Organs from oppressed minorities and prisoners
Governments and organised crime networks
Human Trafficking in the U.S. and Europe
Trafficking for sexual exploitation most common type
https://www.unov.org/unov/en/unodc.html
72% of detected survivors in North America
“with the market forces of prostitution driving demand for human trafficking of women and girls“
https://nij.ojp.gov
“Studies find that up to 80% of samples of women and girls serving as prostitutes had been coerced or forced to engage in prostitution by pimps or traffickers.“
United States
“accounts for nearly 50% of all IP addresses engaging in P2P file sharing of child pornography images“
The New York Times (2019)
“ The images are horrific. Children, some just 3 or 4 years old, being sexually abused and in some cases tortured.
Some followed by travel to Latin America and the Caribbean.
Europe
The majority of trafficking victims, Bulgaria, Romania, Moldowa, Ukraine, Nigeria
Brought to Central and Western Europe for exploitation.
A CALL FOR TARGETED ACTION
We call for decisive, targeted measures to end human trafficking. These include but are not limited to the following:
Public Awareness
Legislation
Law Enforcement
Survivors
Culture
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Are drug regulators for hire?
From FDA to MHRA: are drug regulators for hire?
https://www.bmj.com/content/377/bmj.o1538
Proportion of budget derived from Industry
European Medicines Agency, 89% (2022)
Therapeutic Goods Administration, 96%
US Food and Drug Administration, 56% (Total budget $6,100,000,000)
Medicines and Healthcare Products Regulatory Agency, 86%
Japan, PDMA 85%
Health Canada, 50.5% (Total budget C$2,700,000,000)
Australia TGA and Canada HC
Conflicts of interests NOT available as public information
Covid-19 vaccine committee members who declared a financial CoI
UK, HMRA, 32%
Australia, TGA, 50%
Japan, PMDA, 75%
Regulators do NOT routinely receive patient level datasets
Australia, TGA
Europe, EMA
UK, MHRA
Canada, HC
Proportion of decisions to recommend new medicines v did not approve
Australia, TGA, 94%
Europe, EMA, 88%
UK, MHRA, 98.5%
US, FDA, 69%
Canada, HC, 83%
The revolving door
FDA, nine out of 10 of its past commissioners, 2006 to 2019 went on to secure roles linked with pharmaceutical companies
1992, US Congress
Passed the Prescription Drug User Fee Act (PDUFA)
Allowing industry to pay “user fees” directly to FDA
2005 UK, House of Commons’ health committee
Evaluated the influence of the drug industry on health policy,
including the Medicines and Healthcare Products Regulatory Agency (MHRA).
The committee was concerned
Industry funding could cause MHRA, to “lose sight of the need to protect and promote public health above all else as it seeks to win fee income from the companies.”
BMJ investigation (2022)
We found that industry money permeates the globe’s leading regulators,
raising questions about their independence
Industry money saturates the globe’s leading regulators.
The BMJ found that the majority of regulators’ budget
—particularly the portion focused on drugs—
is derived from industry fees
A string of drug and device scandals
Opioids, Alzheimer’s drugs, influenza antivirals, pelvic mesh, joint prostheses, breast and contraceptive implants, cardiac stents, pacemakers.
Sociologist Donald Light, Rowan University, New Jersey
“Like the FDA, the TGA was founded to be an independent institute.
However, being largely funded by fees from the companies whose products it is charged to evaluate is a fundamental conflict of interest,
and a prime example of institutional corruption.”
It is no longer possible for doctors and patients to receive unbiased, rigorous evaluations from drug regulators.
“Countries have independent safety boards for airlines and their passengers. Why not for drugs and patients too?”
FDA
“It’s the opposite of having a trustworthy organisation independently and rigorously assessing medicines.
They’re not rigorous, they’re not independent, they are selective, and they withhold data.
Doctors and patients must appreciate how deeply and extensively drug regulators can’t be trusted so long as they are captured by industry funding.”
External advisers
Advisory panels intended to provide regulators with independent expert advice
BMJ investigation
Several expert advisers for covid-19 vaccine advisory committees in the UK and US had financial ties with vaccine manufacturers
Revisiting financial conflicts of interest in FDA advisory committees
https://pubmed.ncbi.nlm.nih.gov/25199895/
Large study, FDA advisory committee members over 15 years,
those with financial interests solely in the sponsoring firm were more likely to vote in favour of the sponsor’s product.
TGA (FoI in BMJ)
Conducted its covid-19 vaccine assessments based on “the information provided by the vaccine’s sponsor.”
TGA said it had not seen the source (individual participant level datasets) data from the covid-19 vaccine trials.
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Pirola panic
Pirola, BA.2.86
An asteroid that hangs out by Jupiter
World Health Organization, BA.2.86 a “variant under monitoring”
https://www.gov.uk/government/publications/sars-cov-2-genome-sequence-prevalence-and-growth-rate/sars-cov-2-genome-sequence-prevalence-and-growth-rate-update-30-august-2023
First monitoring 14 August 2023, (horizon scanning)
34 amino acid differences compared with BA.2
https://www.bmj.com/content/382/bmj.p1964
All in spike protein
https://www.cdc.gov/respiratory-viruses/whats-new/covid-19-variant.html
36 amino acid changes compared with the 2023 circulating XBB.1.5
This number of genetic differences, is roughly of the same magnitude as seen between the initial Omicron variant (BA.1) and previous variants, such as Delta (B.1.617.2)
Declared a variant on 18 August 2023
Week beginning 28 August 2023
2 UK sequences found
Denmark, Israel, US, SA, (unlinked)
https://www.gov.uk/government/news/flu-and-covid-autumn-vaccine-programmes-brought-forward
Precautionary measure taken to protect those most vulnerable from illness during winter following the identification of COVID-19 variant BA.2.86.
Vaccinations are now set to start on 11 September 2023
UKHSA suggests speeding up autumn vaccine programme will deliver greater protection,
supporting those at greatest risk of severe illness and reducing the potential impact on the NHS.
People in care homes for older people,
the clinically vulnerable,
those aged 65 and over,
health and social care staff, and carers.
Those who fall into higher-risk groups are being encouraged to take up the jab as soon as they’re invited.
Chief Executive of the UK Health Security Agency, Dame Jenny Harries
As we continue to live with COVID-19 we expect to see new variants emerge.
Thanks to the success of our vaccine programme, we have built strong, broad immune defences against new variants throughout the population.
https://www.ama-assn.org/delivering-care/public-health/latest-cdc-fall-covid-variants-new-flu-guidelines-plus-malaria-health
A variant that's adept at evading immunity would not necessarily take off in a population if it doesn't spread efficiently.
Inherent transmissibility unknown
https://www.bmj.com/content/382/bmj.p1964
Transmissibility and severity
Little is yet known about the transmissibility of BA.2.86 or whether it may cause more severe disease,
but scientists do not expect it to be much different from previous omicron strains currently in circulation.
Sore throat 63.41
Runny nose 59.18
Headache 55.84
Blocked nose 54.3
Sneezing 52.5
Cough no phlegm 50.71
Hoarse voice 38.77
Cough with phlegm 38.38
Muscle pains aches 31.58
Fatigue 23.88
Swollen neck glands 20.67
Altered smell 20.54
Dizzy light headed 19.77
Eye soreness 18.1
Earache 15.15
Loss of smell 14.38
Fever 13.61
Joint pain shoulders 13.35
Chest pain tightness 12.84
Shortness of breath 12.84
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