Covid vaccine and multiple sclerosis
Covid-19 vaccination can induce multiple sclerosis via cross-reactive CD4+ T cells recognizing SARS-CoV-2 spike protein and myelin peptides
https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-2138820?lang=en
Both natural infection and the mRNA based vaccinations can be accompanied by transient autoimmune phenomena,
or onset of autoimmune diseases.
Objective
Two cases of multiple sclerosis (MS),
with clinical and new radiological signs,
beginning in close temporal relation to spike (S) protein mRNA based vaccinations.
Aim
The onset of MS in these two cases is very likely caused by CD4+ T cell clones,
that cross-recognize SARSCoV- 2 S protein,
from myelin proteins.
Method
Spike specific CD4+ T cells from peripheral blood,
and CD4+ T cells from CSF sample were isolated,
then underwent autoantigen screening test.
(An endogenous antigen that stimulates the production of autoantibodies)
A list of well-known MS related autoantigens,
Result(s)
Self-reactive T cells were detected from Spike specific T cell population,
also showed reactivity to MBP, MOG, (Myelin oligodendrocyte glycoprotein) peptides PLP peptide pools.
Multiple sclerosis and myelin basic protein: insights into protein disorder and disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8810476/
Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.
MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS).
MS is characterized by CNS inflammation, demyelination, and axonal loss.
Finally,
we found proinflammatory T cell clones,
that recognize both Spike protein and immunodominant Myelin basic protein peptides,
and Myelin oligodendrocyte glycoprotein (MOG) peptides, which have previously been implicated in MS.
Conclusion(s)
Detailed studies of both peripheral blood, and CSF derived CD4+ T cells show that the onset of MS in these two cases is very likely caused by CD4+ T cell clones that cross-recognize SARS-CoV-2 S protein derived peptides and peptides derived from myelin proteins, which have previously been implicated in MS.
Posts misrepresent research on multiple sclerosis and COVID-19 vaccines found in WHO database
https://apnews.com/article/fact-check-WHO-COVID-multiple-sclerosis-591321248797
New diagnosis of multiple sclerosis in the setting of mRNA COVID-19 vaccine exposure (January 2022)
https://pubmed.ncbi.nlm.nih.gov/34922126/
Multiple sclerosis (MS) with onset in the setting of acute SARS-CoV-2 virus infection has been reported,
and reactivation of MS following non-mRNA COVID-19 vaccination has been noted,
There have been three reports of newly diagnosed MS following exposure to mRNA COVID-19 vaccine.
The association cannot be determined to be causal,
We report a series of 5 cases of newly diagnosed MS following recent exposure to mRNA COVID-19 vaccines.
Latency from vaccination to initial presentation varied.
Neurological manifestations and clinical course appeared to be typical for MS,
including response to high dose steroids
Conclusion
Acute neurological deficits in the setting of recent mRNA COVID-19 vaccine administration may represent new onset multiple sclerosis.
Hold a parliamentary vote on whether to reject amendments to the IHR 2005
https://petition.parliament.uk/petitions/635904
https://twitter.com/Johnincarlisle
We are concerned that Parliament has not discussed and will not have a say on the 307 proposed amendments to the International Health Regulations,
AND the amendments to 5 Articles of the IHR that were ADOPTED by the 75th World Health Assembly on 27 May 2022.
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Hard questions for John
Well, Norman asked some firm questions, which is great. We need to be open, honest and change thinking as the evidence leads.
Link to Norman’s YT channel, https://www.youtube.com/@NormanFenton81
And Substack, https://wherearethenumbers.substack.com
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WHO power grab
Article by Article Compilation of Proposed Amendments to the International Health Regulations (2005)
https://apps.who.int/gb/wgihr/pdf_files/wgihr1/WGIHR_Compilation-en.pdf
My previous videos
https://www.youtube.com/watch?v=qXdO_7J1Lx8
https://www.youtube.com/watch?v=ooKyYEvIhYk
Mr. Rob Roos MEP
https://www.youtube.com/watch?v=C_19i26FmAY
WHO could gain powers to impose lockdown on UK
MPs fear new treaty designed to increase the organisation’s powers would enable it to enforce border closures and vaccine passports
https://www.telegraph.co.uk/politics/2023/05/25/who-pandemic-treaty-lockdown-uk-ministers-fear/
A new “pandemic treaty” under discussion
Lockdown measures could be imposed on the UK by the World Health Organisation (WHO)
Under sweeping new powers
Member states
Obliged to follow the agency’s instructions,
Force Britain to spend five per cent of its health budget on preparing for another virus outbreak
Plus a proportion of GDP
Plans to increase the WHO’s powers
Require countries to hand over the recipe of vaccines
To counter misinformation
Enforce border closures
Quarantine measures
Vaccine passports
Conservative MPs
Written to ministers,
“ambition evident…for the WHO to transition from an advisory organisation to a controlling international authority”
Urge the Foreign Office to block powers
that “appear to intrude materially into the UK’s ability to make its own rules and control its own budgets”.
Changes to make WHO advice 'binding'
Part of post pandemic plans, WHO’s International Health Regulations
First proposed in 2021 by world leaders
Improve alert systems, data-sharing, production of vaccines
“foster an all of government and all of society approach”.
Now, 300 proposed amendments to the IHRs
WHO’s advice “binding”
“recognise WHO as the guidance and coordinating authority of international public health response…and undertake to follow WHO’s recommendations in their international public health response”.
'Particularly worrying'
Six conservative MPs, Esther McVey
Written to Andrew Mitchell, (Foreign Office minister),
to call for a Commons vote on the draft treaty and regulations before they are signed.
Ms McVey
There is, rightly, growing concern about the WHO’s Pandemic Treaty and International Health Regulations.
The plans represent a significant shift for the organisation,
from a member-led advisory body to a health authority with powers of compulsion.
This is particularly worrying when you consider the WHO’s poor track record on providing consistent, clear and scientifically sound advice for managing international disease outbreaks
(Sir John Redwood, David Davis, Philip Davies, Sir Christopher Chope and Danny Kruger)
Mr Kruger
“Coordination and cooperation in a public health emergency is sensible but ceding control over health budgets and critical decision-making in a pandemic to an unelected international organisation seems profoundly at odds with national autonomy and democratic accountability.”
Campaigners also expressed concern about increasing the WHO’s role in identifying misinformation (lab leak changes of view)
Molly Kingsley, UsForThem
“We should all be concerned about the WHO being ordained as an arbiter of pandemic truth,
especially given its poor record during the pandemic,
such as its claim that Covid was definitively zoonotic in origin
and its April 2020 denial of the role of natural immunity in protecting against infection.”
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Astonishing rise in abnormal heart rhythms
Number of UK people with heart rhythm condition rises by 50% in a decade
https://www.bhf.org.uk/what-we-do/news-from-the-bhf/news-archive/2023/may/new-figures-show-the-number-of-uk-people-with-heart-rhythm-condition
Atrial fibrillation, 1.5 million sufferers in the UK
1milloin in 2013 – a 50% rise over the decade.
One in 45 people in the UK
Five times more likely to stroke, potentially fatal or life-changing
Believed to contribute to one in five strokes
Estimated, at least another 270,000 people undiagnosed
(= 1,770,000)
Symptoms of atrial fibrillation
Palpitations
Breathlessness
Dizziness
Paroxysmal
Our medical director Professor Sir Nilesh Samani
These figures show a quite astonishing rise in the number of people diagnosed with atrial fibrillation.
Research has helped us understand the links between atrial fibrillation and stroke
We also need to continue to harness the power of science to develop new and innovative tools for identifying people at increased risk
BHF
The figures have been released as we launch a new campaign calling on the public to support our research
The campaign aims to inspire people’s wonder at the complexity and preciousness of their own hearts and how lifesaving research can help if it goes wrong.
Questions
What was the rate of increase or change in prevalence during 2019, 2020, 2021, 2022, 2023?
Has the increase been correlated with any particular factors that have changed between 2019 and 2023?
What is the strength of any possible correlations?
Is there temporality with possible correlations?
Is there a plausible mechanism to explain correlations?
How do UK figures of increased AF relate to other countries?
Are there any common factors that connect potential changes across differing countries?
https://www.thelancet.com/journals/lanepe/article/PIIS2666-7762(22)00079-5/fulltext
June 2022
Data only up to 31 December 2017
https://www.nhs.uk/conditions/atrial-fibrillation/
See a GP or call 111 if:
• you have chest pain that comes and goes
• you have chest pain that goes away quickly but you're still worried
• you notice a sudden change in your heartbeat
• your heart rate is consistently lower than 60 or above 100 (particularly if you're experiencing other symptoms of atrial fibrillation, such as dizziness and shortness of breath)
It's important to get medical advice to make sure it's nothing serious.
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Excess deaths in Canada
Norman’s sub stack, https://wherearethenumbers.substack.com/about
Canada excess deaths https://www150.statcan.gc.ca/n1/pub/71-607-x/71-607-x2021028-eng.htm
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Covid vaccinations in UK mostly stopping
UK to stop primary covid vaccine course
https://twitter.com/DHSCgovuk
https://twitter.com/UKHSA
Getting a 1st and 2nd dose of the COVID-19 vaccine
https://www.nhs.uk/conditions/covid-19/covid-19-vaccination/getting-a-1st-and-2nd-dose-of-the-covid-19-vaccine/
Currently, 75 + or comorbidities
CDC advice as today
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/expect.html
J and J in the US
About 19 million people
More than 31.5 million doses
December 2021 (UK)
https://www.gov.uk/government/publications/use-of-the-astrazeneca-covid-19-vaccine-jcvi-statement-7-may-2021/use-of-the-astrazeneca-covid-19-azd1222-vaccine-updated-jcvi-statement-7-may-2021
https://www.express.co.uk/news/uk/1540424/astrazeneca-vaccine-not-used-booster-what-happened-oxford-mRNA-evg
A spokesperson JCVI
The results of the COV-BOOST trial conducted during the summer of 2021 provided good evidence that mRNA vaccines are the most effective option for the UK’s booster programme.
(Denmark stopped AZ in April 2021)
Patients launch legal action against AstraZeneca over its covid-19 vaccine (BMJ)
https://www.bmj.com/content/380/bmj.p725
AZ been sent pre-action protocol letters
First step in a legal claim, 75 claimants
Some have survived with catastrophic injuries following blood clots.
Relatives representing others who suffered adverse reactions.
Consumer Protection Act 1987
Must show that the vaccine was not as safe as the public were entitled to expect
Vaccine Damage Payment Scheme
Limited to £120 000 per claim, applicants must prove severe disablement
Administrative staff, four to 80
Freedom of information request
NHS Business Services, by 6 March 2023
Scheme had received 4,017 claims
622 concerned AstraZeneca vaccine
348 the Pfizer
43 the Moderna vaccine
334 were for a severe adverse reaction, (claims by relatives)
Australia
https://www.youtube.com/watch?v=2i8Jxciomzc&t=34s
Population, 26 million
3,374 claims
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Experimental influenza vaccine
Clinical Trial of mRNA Universal Influenza Vaccine Candidate Begins
https://www.niaid.nih.gov/news-events/clinical-trial-mrna-universal-influenza-vaccine-candidate-begins
https://clinicaltrials.gov/ct2/show/NCT05755620
Clinical trial, experimental universal influenza vaccine
National Institute of Allergy and Infectious Diseases’ (NIAID) Vaccine Research Center (VRC),
(part of National Institutes of Health)
Enrolling volunteers, Duke University, Durham, North Carolina
Phase 1 trial
H1ssF-3928 mRNA-LNP, for safety and ability to induce an immune response.
N = up to 50 healthy volunteers, (18 through 49)
Three groups of 10 participants each
10, 25 and 50 micrograms
After evaluation of the data to determine an optimum dosage,
an additional 10 to receive the optimum dosage
Study include a group, receive a current quadrivalent.
Comparison between “immunogenicity and safety”
Follow-up appointments for up to one year
Annual seasonal flu vaccines
Valuable tools in controlling the spread and severity of influenza
Do not provide immunity against every flu strain.
Each year is based on prediction
Vaccine manufacturers then need time
(dominant strains of the virus can change)
An effective universal flu vaccine
Acting NIAID Director Hugh Auchincloss
Protecting its recipients against a wide variety of strains,
ideally providing durable long-term immunity.
“A universal influenza vaccine would be a major public health achievement and could eliminate the need for both annual development of seasonal influenza vaccines, as well as the need for patients to get a flu shot each year”
Defence against the spread of a future flu pandemic.
Both vaccines use a specific portion of a flu protein,
Hemagglutinin (HA) stern (not head) flu protein
UK cements 10-year-partnership with Moderna in major boost for vaccines and research
https://www.gov.uk/government/news/uk-cements-10-year-partnership-with-moderna-in-major-boost-for-vaccines-and-research
to produce up to 250 million vaccines per year
https://www.theguardian.com/business/2022/jun/22/moderna-build-uk-mrna-vaccine-research-manufacturing-centre-covid
£1bn deal with the UK government
UK government has committed to buying Moderna’s vaccines for the next decade.
Harwell, Oxfordshire
https://www.bbc.co.uk/news/uk-england-oxfordshire-64856379
Innovation and Technology Centre built by the 2025
Moderna
provide the UK public with access to mRNA vaccines for a wide range of respiratory diseases
Questions
Control of antigen dose?
How long antigen will be produced for?
Degree of systemic distribution?
Degree of systemic inflammation?
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Are covid vaccines still causing excess deaths
Covid symptoms are mostly ‘cold like’ and mild
Symptom Prevalence (%)
Sore throat 60.45
Blocked nose 57.17
Runny nose 52.68
Headache 49.74
Sneezing 49.05
Cough no phlegm 46.46
Hoarse voice 40.24
Cough with phlegm 40.24
Muscle pains aches 30.57
Fatigue 23.66
Dizzy light headed 21.07
Altered smell 20.38
Eye soreness 18.83
Swollen neck glands 18.65
Loss of smell 17.27
Shortness of breath 14.51
Earache 13.99
Joint pain shoulders 13.99
Fever 13.47
Chest pain tightness 13.3
UK excess deaths
https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths
Week 16 (W/E 21 April)
+ 22.1% 2,540
Week 17 (W/E 28 April)
+ 12.9% 1,569
Week 18 (W/E 5 May)
+ 5.4% 598
Professor Fenton. Substack, https://wherearethenumbers.substack.com/about
And YouTube, https://www.youtube.com/@NormanFenton81/videos
Canada excess deaths
https://www150.statcan.gc.ca/n1/pub/71-607-x/71-607-x2021028-eng.htm
The actual number of observed deaths is ‘at least’ the black dotted line.
Whenever the black line is above the blue line it is probable that there were excess deaths
Whenever the black line is above the red dotted line it is almost certain there are excess deaths.
So, it is likely there have been excess deaths every month since mid-March with especially large peaks in April-May and December.
Any number bigger than the red dotted line, then we expect something new is likely causing this especially high number of deaths.
Australia excess deaths
https://www.abs.gov.au/statistics/health/causes-death/provisional-mortality-statistics/jan-2023
January 2023
There were 14,547 deaths in January,
12.4% more than the baseline average
(but 10.5% less than January 2022)
COVID-19 caused 213 deaths in February, down from 731 in January
Jan to December 2022
In 2022, there were 190,394 deaths,
which is 25,235 (15.3%) more than the historical average
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International covid summit, European Parliament report
MEP Cristian Terhes, Dr. Robert Malone, MEP Christine Anderson, MEP Ivan Sincic MEP Mislav Kolakušić
Original YT link, https://www.youtube.com/watch?v=anJWQ5eDfio
International European Parliament covid summit part 1, https://www.youtube.com/watch?v=bFLPWWCAHfQ&t=11463s
Part 2, https://www.youtube.com/watch?v=vJ93mW_sMPo&t=11321s
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WHO power grab
Poster and books, free download https://drjohncampbell.co.uk/
Article by Article Compilation of Proposed Amendments to the International Health Regulations (2005)
https://apps.who.int/gb/wgihr/pdf_files/wgihr1/WGIHR_Compilation-en.pdf
From video 9th May
Article 1 Definitions
“standing recommendation” means non-binding advice issued by WHO
“temporary recommendation” means non-binding advice issued by WHO
Article 2 Scope and purpose
including through health systems readiness and resilience in ways that are commensurate with and restricted to public health risk all risks with a potential to impact public health,
Article 3 Principles
The implementation of these Regulations shall be with full respect for the dignity, human rights and fundamental freedoms of persons
Article 10 Verification
whilst encouraging the State Party to accept the offer of collaboration by WHO, taking into account the views of the State Party concerned.
Article 11 Exchange of information
WHO shall facilitate the exchange of information between States Parties and ensure that the Event Information Site For National IHR Focal Points offers a secure and reliable platform
Article 12 Determination of a public health emergency of international concern public health emergency of regional concern, or intermediate health alert
2. If the Director-General considers, that a potential or actual public health emergency of international concern is occurring,
If the Director-General determines that the event constitutes a public health emergency of international concern, and the State Party are in agreement regarding this determination,
5. If the Director-General, following consultations with the Emergency Committee and relevant States Parties the State Party within whose territory the public health emergency of international concern has occurred,
New para 6: Where an event has not been determined to meet the criteria for a public health emergency of international concern, but the Director-General has determined it requires heightened international awareness and a potential international public health response,
the Director-General, on the basis of information received, may determine at any time to issue an intermediate public health alert to States Parties
Article 13 Public health response
3. At the request of a State Party, WHO shall collaborate clearly defined assistance to a State Party offer assistance to a State Party in the response to public health risks and other events by providing technical guidance, health products, technologies, know-how, deployment of civil medical personals,
The State Party shall accept or reject such an offer of assistance within 48 hours and, in the case of rejection of such an offer, shall provide to WHO its rationale for the rejection, which WHO shall share with other States Parties.
4. If WHO, … determines that a public health emergency of international concern is occurring, it may shall offer, in addition to the support indicated in paragraph 3 of this Article,
5. When requested by WHO, States Parties should shall provide, to the extent possible, support to WHO- coordinated response activities,
including supply of health products and technologies, especially diagnostics and other devices, personal protective equipment, therapeutics, and vaccines, for effective response to PHEIC occurring in another State Party’s jurisdiction and/or territory,
NEW Article 13A WHO Led International Public Health Response
States Parties recognize WHO as the guidance and coordinating authority of international public health response during public health Emergency of International Concern and undertake to follow WHO’s recommendations in their international public health response.
New Article 13A: Access to Health Products, Technologies and Know-How for Public Health Response
Immediately after the determination of a public health emergency of international concern under Article 12, the Director General shall make an immediate assessment of availability and affordability of required health products and make recommendations, including an allocation mechanism,
3. States Parties shall provide, in their intellectual property laws and related laws and regulations, exemptions and limitations to the exclusive rights of intellectual property holders to facilitate the manufacture, export and import of the required health products, including their materials and components.
e) establish a repository for cell-lines to accelerate the production and regulatory of similar biotherapeutics products and vaccines
NEW Chapter IV (Article 53 bis-quater): The Compliance Committee 53 bis Terms of reference and composition
1. The State Parties shall establish a Compliance Committee that shall be responsible for:
New Article 54 bis – Implementation4]
The Health Assembly shall be responsible to oversee and promote the effective implementation of these Regulations.
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Vitamin D, larger doses
Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients:
Insights from a seven year experience
https://pubmed.ncbi.nlm.nih.gov/30611908/
Dayton and Cincinnati, Ohio
Vitamin D3 is a hormone produced in the skin,
in amounts estimated up to 25,000 international units (IUs) a day,
by the action of UVB radiation
Vitamin D deficiency is common,
lack of adequate sun exposure to the skin,
vitamin D is present in very few food sources.
Deficiency is strongly linked to increased risk for a multitude of diseases,
several of which have historically been shown to improve dramatically with either adequate UVB exposure to the skin,
or to oral supplementation with vitamin D.
These diseases include
Asthma, psoriasis, rheumatoid arthritis, rickets and tuberculosis.
All patients in our hospital have been routinely screened on admission for vitamin D deficiency since July 2011
Offered supplementation to either correct or prevent deficiency
We have admitted over 4,700 patients
(vast majority agreed to supplementation)
5000 or 10,000 IUs/day.
125 micrograms or 250 micrograms
Due to disease concerns,
A few agreed to 20,000 to 50,000 IUs/day.
500 micrograms to 1, 250 micrograms (1.25mg)
There have been no cases of vitamin D3 induced hypercalcemia,
or any adverse events attributable to vitamin D3
Three patients with psoriasis
Marked clinical improvement using 20,000 to 50,000 IUs/day
Analysis of 418 inpatients on D3
Long enough to develop 25OHD3 blood levels > 74.4 ng/ml,
showed a mean 25OHD3 level of 118.9 ng/ml
(range from 74.4 to 384.8 ng/ml)
Average serum calcium level in the vit D group of 418
9.6 mg/dl
Range of 8.6 to 10.7
(Normal 8.5 to 10.5)
Average serum calcium level in the non vit D group of 777
Mean 25OHD3 level of 27.1 ng/ml
9.5 mg/dl
Range of 8.4 to 10.7
Parathyroid hormone levels
A hormone released in response to low calcium levels
D3 users, 24.2 pg/ml
Non D3 users, 30.2 pg/ml
In summary
Long-term supplementation with vitamin D3 in doses ranging from 5000 to 50,000 IUs/day appears to be safe.
Conclusion
Daily oral intake of vitamin D3 ranging from 5000 IU/d to 60,000 IU/d for several years was well tolerated and safe,
in both our patients and staff.
The mean 25OHD blood levels in our patients appear to take around 12 months to plateau on 5000 IU/d and 10,000 IU/d.
The average 25OHD values
Patients taking 10,000 IU/d at 12 months = 96 ng/ml
Then retested at 16 months = 97 ng/ml
Currently considered upper limit of normal, 100 ng/ml
Conflicts of Interest
The authors have no conflicts of interest to disclose.
Funding
This research was performed without external funding.
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Excess deaths in all age groups
'Brits are dying in their tens of thousands - and we don't really have any idea why'
https://www.mirror.co.uk/news/health/brits-dying-tens-thousands-dont-29955386
Tens of thousands more Brits died than usual from May to December 2022,
excluding Covid as a cause of death,
raising serious questions as to why so many died
May to December 2022, 32,441 excess deaths
The number of deaths registered in the UK in the week ending 21 April 2023 (Week 16)
Was 14,024
22.1% above the five-year average
2,540 excess deaths
The number of deaths registered in the UK in the week ending 28 April 2023
https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregisteredweeklyinenglandandwalesprovisional/weekending28april2023
(Week 17)
Was 13,690
12.9% above the five-year average
1,569 excess deaths
UK excess deaths in 2 weeks = 4,190
England and Wales
12,152 deaths
459 of these deaths mentioned novel coronavirus
(3.8% of all deaths)
Of the 459 deaths
65.6% (301 deaths) covid recorded as underlying cause
The number of deaths was above the five-year average
Private homes, 23.3% (646 excess deaths)
Hospitals, 10.7% (521 excess deaths)
Care homes, 8.4% (186 excess deaths)
Other settings, 14.3% (117 excess deaths)
Excess mortality in England and English regions: May 2023 update
Latest update, 12th May, data to end of April 2023
https://www.gov.uk/government/statistics/announcements/excess-mortality-in-england-and-english-regions-may-2023-update
https://app.powerbi.com/view?r=eyJrIjoiYmUwNmFhMjYtNGZhYS00NDk2LWFlMTAtOTg0OGNhNmFiNGM0IiwidCI6ImVlNGUxNDk5LTRhMzUtNGIyZS1hZDQ3LTVmM2NmOWRlODY2NiIsImMiOjh9
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Three parent baby
First three parent baby born in UK
First British ‘3 parent baby’
Maternal spindle transfer repair is done before fertilisation
Pronuclear transfer, repair is done after fertilisation
https://www.theguardian.com/science/2015/feb/02/three-parent-babies-explained
https://www.express.co.uk/news/science/1768481/three-parent-baby-mitochondrial-donation-treatment-uk
Scientific and Ethical Issues in Mitochondrial Donation
https://www.tandfonline.com/doi/full/10.1080/20502877.2018.1440725
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31868-3/fulltext
Question 1.
Is this an ethical form of zygote generation?
Question 1.a.
Is current IVF ethical?
Question 2.
Should reproduction he medicalised?
Question 2.a.
Is reproduction a right or a privilege / gift?
Question 3.
Are you happy with germ line alterations?
Question 4.
Will this change spread through human populations?
Question 5.
Are there any unforeseen consequences in future generations?
Question 6.
Could this technology be abused in the future or in other places?
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International excess deaths
Excess deaths, dramatic increase, week ending 21 April 2023
https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregisteredweeklyinenglandandwalesprovisional/weekending21april2023
The number of deaths registered in the UK in the week ending 21 April 2023
(Week 16)
Was 14,024
22.1% above the five-year average
2,540 excess deaths,
of these deaths, 615 involved COVID-19
England and Wales
Week 16, 12,420 deaths were registered in England and Wales
538 of these deaths mentioned novel coronavirus (4.3% of all deaths)
Of the 538 deaths involving COVID-19, 66.5% (358 deaths) had this recorded as the underlying cause of death
The number of deaths was above the five-year average
Private homes (29.0% above, 771 excess deaths)
Hospitals (20.2% above, 924 excess deaths)
Care homes (25.3% above, 525 excess deaths)
Other settings (11.7% above, 92 excess deaths)
Could Bradford Hill criteria help?
The larger the association, the more likely that it is causal.
Consistent findings observed by different persons in different places
Lack of alternative explanations
The effect has to occur after the cause
Greater exposure should generally lead to greater incidence of the effect.
A plausible mechanism between cause and effect is helpful
Coherence between epidemiological and laboratory findings increases the likelihood of an effect.
Occasionally it is possible to appeal to experimental evidence
Analogies or similarities between the observed association and any other associations.
Sometimes, reversibility
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WHO cenralised power?
Countries from around the world are currently working on negotiating and/or amending two international instruments,
which will help the world be better prepared when the next event with pandemic potential strikes.
The Intergovernmental Negotiating Body (INB)
https://inb.who.int
to draft and negotiate a convention, agreement or other international instrument to strengthen pandemic prevention, preparedness and response
(commonly known as the Pandemic Accord).
Amendments to the International Health Regulations
https://www.who.int/teams/ihr/working-group-on-amendments-to-the-international-health-regulations-(2005)
https://apps.who.int/gb/wgihr/pdf_files/wgihr1/WGIHR_Compilation-en.pdf
to amend the current International Health Regulations (2005)
https://apps.who.int/gb/wgihr/
https://www.who.int/publications/i/item/9789241580496
66 2005 articles
Underlined and bold = proposal to add text
Strikethrough = proposal to delete existing text
(cut and paste does not copy strike through so I’ve put them in comic sans)
Article 1 Definitions
“standing recommendation” means non-binding advice issued by WHO
“temporary recommendation” means non-binding advice issued by WHO
Article 2 Scope and purpose
including through health systems readiness and resilience in ways that are commensurate with and restricted to public health risk all risks with a potential to impact public health,
Article 3 Principles
The implementation of these Regulations shall be with full respect for the dignity, human rights and fundamental freedoms of persons
Article 4 Responsible authorities
each State Party should inform WHO about the establishment of its National Competent Authority responsible for overall implementation of the IHR that will be recognized and held accountable
Article 5 Surveillance
the State Party may request a further extension not exceeding two years from the Director-General, who shall make the decision refer the issue to World Health Assembly which will then take a decision on the same
WHO shall collect information regarding events through its surveillance activities
Article 6 Notification
No sharing of genetic sequence data or information shall be required under these Regulations.
Article 9: Other Reports
Before taking any action based on such reports, WHO shall consult with and attempt to obtain verification from the State Party in whose territory the event is allegedly occurring
Article 10 Verification
whilst encouraging the State Party to accept the offer of collaboration by WHO, taking into account the views of the State Party concerned.
Article 11 Exchange of information
WHO shall facilitate the exchange of information between States Parties and ensure that the Event Information Site For National IHR Focal Points offers a secure and reliable platform
Parties referred to in those provisions, shall not make this information generally available to other States Parties, until such time as when:
(e) WHO determines it is necessary that such information be made available to other States Parties to make informed, timely risk assessments.
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Update from John
Supportive video from Dr. Dhand, https://www.youtube.com/watch?v=oaP5-CQP0wg&t=239s
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Cannabidiol and covid
Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response
(Preprint)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987002/
https://www.science.org/doi/10.1126/sciadv.abi6110
Cannabidiol (CBD)
Potential regulator of the host stress and antiviral inflammatory responses
(cannabinoid class of natural products)
Hemp, cannabis plants,
Less than 0.3% psychotropic tetrahydrocannabinol (THC)
Oral solution of CBD is a U.S. FDA approved drug
High-purity CBD inhibits SARS-CoV-2 replication in human lung epithelial cells
Pretreated human lung cells (with ACE2 receptor)
for 2 hours with CBD before infection with SARS-CoV-2.
CBD potently inhibited viral replication under nontoxic conditions
(no toxicity was observed at the effective doses)
Worked in other human lung cell lines, worked in monkey kidney cells
Tested on Wuhan strain and 3 VOCs
Their ability to infect cells was comparably inhibited by CBD
CBD or other cannabinoids?
Checked 97 to 100% pure using quantitative nuclear magnetic resonance (qNMR).
No toxicity was observed for any of the CBD preparations at the doses used to inhibit viral infection
The CBD metabolite 7-OH-CBD, 7-hydroxy-cannabidiol
exhibits antiviral activity
Others did not work
Combining CBD with THC (1:1) significantly suppressed CBD efficacy,
consistent with competitive inhibition by THC.
CBD and 7-OH-CBD metabolite are the active and equipotent ingredients for the treatment of epilepsy
CBD acts at an early step after viral entry into cells
CBD targets host cell processes.
CBD inhibits viral RNA expression and reverses viral-induced changes in host gene expression
CBD effectively eradicated viral RNA expression in the host cells
Prevents changes in the cell produced by the virus to force the cell to produce new viral particles
CBD induces strong activation of genes associated with the host stress response.
Together, these results suggest that CBD acts to prevent viral protein translation and associated cellular changes.
Induction of viral genes for spike, envelope, and nucleocapsid proteins is reduced ~99% with CBD
CBD induction of increased transcription of 3 defensive endoplasmic reticulum genes
CBD induces interferon expression as part of its antiviral activity
CBD suppress viral infection,
and promote degradation of viral RNA
(SARS-CoV-2 infection suppresses the interferon signaling pathway)
CBD sufficiently lowers the effective viral titer to enable normal host activation of the interferon pathway.
CBD effectively reversed viral induction of cytokines that can lead to deadly cytokine storm
CBD treatment significantly inhibits SARS-CoV-2 replication in mice
After viral the challenge,
administration of CBD continued twice daily for an additional 4 days
CBD treatment significantly inhibited viral replication in lungs and nasal turbinates at day 5 after infection
Lower dose of CBD reduced viral load by 4.8-fold in lungs
Higher dose of CBD reduced viral load by 40 -fold in lungs
During this period, the mice showed no signs of clinical disease
These results establish the preclinical efficacy of CBD as an antiviral drug for SARS-CoV-2 during early stages of infection.
CBD is negatively associated with indications of SARS-CoV-2 infection in patient medical records
Given that high-purity CBD preparations are taken by a large number of individuals,
we examined whether CBD prescriptions are associated with indications of SARS-CoV-2 infection
An oral solution of CBD (100 mg/ml) (CBD100) is often used for the treatment of seizures
Analysis of 1,212 patients
Matched to control group counterparts
6.2% (75 patients) with CDB
8.9% for non-CBD patients
(P = 0.014)
Odds ratio (OR) of 0.65, (P = 0.009)
Odds ratio (OR) of 0.48, (P = 0.006)
Potential of Cannabidiol for the Treatment of Viral Hepatitis
https://scholar.google.com/scholar_lookup?title=Potential+of+cannabidiol+for+the+treatment+of+viral+hepatitis&author=H.+I.+Lowe&author=N.+J.+Toyang&author=W.+McLaughlin&publication_year=2017&journal=Pharm.+Res.&pages=116-118
CBD inhibited HCV replication by 86.4%
(Not Hep B)
Other RNA viral infections
Common cold
Influenza
SARS / MERS
Dengue
Hep C and E
Ebola
Rabies
Polio
Mumps
Measles
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Vitamin D and prostate cancer
Free posters and books, https://drjohncampbell.co.uk
Circulating vitamin D level and mortality in prostate cancer patients: a dose–response meta-analysis
https://pubmed.ncbi.nlm.nih.gov/30352424/
Results
Higher vitamin D level could reduce the risk of death among prostate cancer patients.
Association of circulating 25-hydroxyvitamin D level with prognosis of prostate cancer
We conducted a dose-response meta-analysis
Seven eligible cohort studies, n = 7, 808
The summary HR of prostate cancer-specific mortality
An increment of every 20 nmol/L in circulating
vitamin D,
(20 nmol/L = 8 ng/ml)
HR = 0.91, (P = 0.002)
Every 20 nmol/L increment in 25-hydroxyvitamin D level was associated with a 9% lower risk of,
all-cause mortality,
and prostate cancer-specific mortality.
Pooled HRs were stable and not obviously changed by any single study.
No evidence of publications bias was observed.
This meta-analysis suggested that higher 25-hydroxyvitamin D level was associated with a reduction of mortality in prostate cancer patients,
and vitamin D is an important protective factor in the progression and prognosis of prostate cancer.
Risk estimates with 95% CI for the association between 25(OH)D and prostate cancer-specific mortality.
Mechanism
Vit D, could cause cell cycle arrest,
and induce apoptosis,
inhibiting cell proliferation in several prostate cancer cell lines
Protection from prostate epithelial cell lines from oxidative stress
Will supplements help?
Effect of Vitamin D3 Supplements on Development of Advanced Cancer: A Secondary Analysis of the VITAL Randomized Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/33206192/
4,000 units (100 micrograms) day
24 of 44 subjects (55%) showed a decrease in the number of positive cores or decrease in Gleason score
Prostate cancer in black Americans
https://aacrjournals.org/cancerrescommun/search-results?page=1&q=African%20American%20Prostate%20Cancer%20Displays%20Quantitatively%20Distinct%20Vitamin%20D%20Receptor&SearchSourceType=1
Cancer prevention
https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/vitamin-d-fact-sheet
Numerous epidemiologic studies have shown that higher intake or blood levels of vitamin D are associated with a reduced risk of colorectal cancer
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