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In summary, this RCT, evaluating the functionality of daily consumption of flaxseed oil containing 2.2 g of ALA, improved verbal fluency in healthy individuals aged between 65 to 80 years, with no abnormalities in cognitive function, despite declines with age. Since the improvement in verbal fluency is significant in cognitive health, as it is one of the factors of Alzheimer’s disease progress [37], further validation studies, with a focus on ALA’s impact on verbal fluency and executive function, are needed to extend the obtained evidence in this study to older adults. #flaxseedoil l #verbalfluency #executivefunction Ogawa, T., Sawane, K., Ookoshi, K., & Kawashima, R. (2023). Supplementation with Flaxseed Oil Rich in Alpha-Linolenic Acid Improves Verbal Fluency in Healthy Older Adults. Nutrients, 15(6), 1499. https://doi.org/10.3390/nu15061499 Ala, cognitive function, age, flax seed oil, executive function, Alzheimer’s , verbal fluency, dha, alpha linolenic acid, docosahexaenoic acid

In summary, research suggests that while young and healthy individuals may have adequate immune defenses against upper respiratory tract infections (URTIs), supplementing with COL can provide valuable support in protecting those who are at a higher risk of infection due to exposure to a heavy workload and increased contact with infectious agents. #colostrum #infections #immune Stachowska, E., Grochans, E., Bühner, L., & Hałasa, M. (2023). Moderate Dose Bovine Colostrum Supplementation in Prevention of Upper Respiratory Tract Infections in Medical University Students: A Randomized, Triple Blind, Placebo-Controlled Trial. Nutrients, 15(8), 1925. https://doi.org/10.3390/nu15081925 Colostrum, bovine colostrum, immune, respiratory tract infection, URTI, oral colostrum

A single dose of mangiferin-quercetin, taken one hour before exercise, significantly improved participants' performance in a demanding physical test. They completed circuits faster and reported feeling less exertion compared to those given a placebo. This suggests the supplement could enhance overall exercise performance by boosting endurance and reducing fatigue. Further studies are needed to confirm these findings in different exercise types and populations. #NaturalEnergyFuel #BreakThroughFatigue #alchepharma Alchepharma,Ralph Turchiano,citation,research,study,Mangiferin,Quercetin,mango,Mangifera indica,exercise performance,single dose,muscle oxygen extraction,basketball simulation,circuit time,perceived exertion,endurance,fatigue,athletes,natural supplement,pre-workout,recovery,brain oxygenation,oxygen extraction,high-intensity exercise,non-athletes,double-blind study,randomized controlled trial,sports performance,athletic performance,exercise science Bourdas, D. I., Travlos, A. K., Souglis, A., Stavropoulou, G., Zacharakis, E., Gofas, D. C., & Bakirtzoglou, P. (2024). Effects of a Singular Dose of Mangiferin–Quercetin Supplementation on Basketball Performance: A Double-Blind Crossover Study of High-Level Male Players. Nutrients, 16(1), 170. https://doi.org/10.3390/nu16010170

"Remarkably, the cognitive scores increased to levels similar to undergraduates taking the same cognitive tests for the first time," Wu said. "Our finding of continuous cognitive growth in older adulthood is unique because most studies show only maintenance of cognitive abilities or cognitive decline over time." #brain #cognitive #aging Leah Ferguson, Debaleena Sain, Esra Kürüm, Carla M. Strickland-Hughes, George W. Rebok, Rachel Wu. One-year cognitive outcomes from a multiple real-world skill learning intervention with older adults. Aging & Mental Health, 2023; 1 DOI: 10.1080/13607863.2023.2197847 Musical expertise makes older adults better listeners by keeping brain young "Playing music makes older adults better listeners by preserving youthful neural patterns as well as recruiting additional compensatory brain regions. Our study provides empirical evidence to support that playing music keeps your brain sharp, young, and focused,” said Dr. DU, corresponding author of this study. Zhang, L., Wang, X., Alain, C., & Du, Y. (2023). Successful aging of musicians: Preservation of sensorimotor regions aids audiovisual speech-in-noise perception. Science Advances. https://doi.org/adg7056 Cognition, learning, DMN, frontoparietal, cognitive control, working memory, episodic memory, default mode network, continuous cognitive growth, successful aging, youthful brain, dementia, Alzheimer's, speech processing, reverse aging brain, improved brain function, older learners

The scientists think that the ethanol vapor must increase ethanol concentrations in the fluid to 20% to successfully treat the infection. This concentration is not toxic to lung cells the scientists created in the lab to mimic human cells. At body temperature, 20% ethanol can not only inactivate the influenza A virus outside of the cells in one minute, but also stop the virus from replicating inside these cells. #influenza #ethanol #virus Tamai, M., Taba, S., Mise, T., Yamashita, M., Ishikawa, H., & Shintake, T. Effect of Ethanol Vapor Inhalation Treatment on Lethal Respiratory Viral Infection With Influenza A. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiad089 Influenza A virus, ethanol, Influenza , Avian Flu, Sars COV 2, coronavirus, inhalation, enveloped virus, etoh vapor, progeny virus, respiratory infections, severe acute respiratory syndrome coronavirus 2

This study showed that the ingestion of adenosine-containing mushrooms and vegetables may effectively increase testicular testosterone production. We conclude that mushrooms with a relatively high adenosine content, such as enokitake, may be useful against aging and fatigue. #enokitake #testosterone #leydig Iguchi, K., Nagashima, K., Mochizuki, J., Yamamoto, H., Unno, K., & Miyoshi, N. (2023). Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models. Nutrients, 15(9), 2142. https://doi.org/10.3390/nu15092142 Adenosine, enokitake mushroom, enoki, testosterone, male menopause, mushrooms, Leydig cells, polyphenols, Flammulina velutipes. Golden needle, winter mushroom, fatigue, anti-aging, post cycle

A 12-week study found that daily beetroot juice supplementation significantly lowered blood pressure and improved exercise capacity in people with chronic obstructive pulmonary disease (COPD). This suggests that beetroot, rich in dietary nitrates, could be a safe and well-tolerated alternative or complement to conventional antihypertensive medications for COPD patients. While further research is needed to confirm long-term benefits and potential interactions with other medications, the study offers encouraging evidence for the potential of beetroot juice as a natural approach to managing COPD symptoms. #COPDBreakthrough #NaturalReliefCOPD #AlchePharma Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC a randomised controlled trialAli M Alasmari, Abdullah S Alsulayyim, Saeed M Alghamdi, Keir E J Philip, Sara C Buttery, Winston A S Banya, Michael L Polkey, Paul C Armstrong, M J Rickman, Timothy D Warner, J A Mitchell, Nicholas S Hopkinson European Respiratory Journal Jan 2023, 2202353; DOI: 10.1183/13993003.02353-2022 Alchepharma,Ralph Turchiano,citation,research,study,beetroot juice and COPD,beetroot juice supplement and COPD,dietary nitrate and COPD,nitric oxide and COPD,blood pressure and COPD,exercise capacity and COPD,alternative treatments for COPD,natural remedies for COPD,ON-BC trial,European Respiratory Journal 2023,Ali M Alasmari et al.,400mg nitrate beetroot juice,6-minute walk distance in COPD,systolic blood pressure in COPD,safety of beetroot juice in COPD

The results of this study provide proof-of-concept that GlyNAC supplementation improves age-associated cognitive decline and supports brain health in aging by improving/correcting brain GSH deficiency, elevated OxS, mitochondrial dysfunction, abnormal mitophagy and autophagy, inflammation, impaired glucose transport/uptake, elevated genomic damage, and reversing the decline in brain neurotrophic growth factors. GlyNAC could be a simple and effective nutritional supplement to support brain health and cognitive function in aging, and warrants additional investigation. #glynac #brainrespiration #cognition Kumar, P., Osahon, O. W., & Sekhar, R. V. (2023). GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging. Antioxidants, 12(5), 1042. https://doi.org/10.3390/antiox12051042 Glynac, glycine, N-Acetylcysteine, correction, GSH Synthesis , cognitive improvement, brain health, GSH, OxS, mitochondrial energetics, autophagy/mitophagy, glucose transporters, inflammation, genomic damage, neurotrophic factors

The manipulation of the timing and dose of kiwifruit may have applications in terms of sleep and recovery (e.g., antioxidant consumption in relation to training) in athletes that warrant further investigation. The results presented suggest a potential role for kiwifruit consumption in sleep promotion and recovery protocols for elite athletes. Consuming 2 kiwifruit 1 h before bed is a practical wholefood-based intervention that can easily be implemented in real-world settings. Kiwifruit is available in wholefood form, but it is also consumed in various processed forms, e.g., drinks, sweets, lyophilised products (i.e., freeze dried), dehydrated products and juices [64]. Further research is warranted to develop protocols and/or products designed specifically to promote sleep and/or recovery in elite athletes. #kiwi #exercise #sleep Doherty, R., Madigan, S., Nevill, A., Warrington, G., & Ellis, J. G. (2023). The Impact of Kiwifruit Consumption on the Sleep and Recovery of Elite Athletes. Nutrients, 15(10), 2274. https://doi.org/10.3390/nu15102274 Kiwi, kiwifruit, sleep, Actinidia Deliciosa, training, recovery, disturbed sleep, anxiety, vitamin c, serotonin, melatonin, folate, Regulatory, Satisfaction, Alertness, Timing, Efficiency, athletes, exercise, overtraining, restful sleep, protocol, wholefood, unexplained underperformance syndrome, uup, overtraining, RU-SATED

A new study suggests that simply swapping one serving of starchy carbohydrates for vegetables daily can significantly improve fatty liver disease (NAFLD), even in advanced stages. Researchers found that after just three months, this minor dietary change led to reductions in liver fibrosis, inflammation, and other NAFLD markers. The key seems to be the type of vegetables chosen: the study focused on four cruciferous varieties (mizuna, chicory, kale, and Chinese mustard) rich in glucobrassicin-derived compounds with antioxidant and anti-fatty liver properties. This easy-to-implement dietary tweak could offer a promising first step for managing and potentially reversing NAFLD. #NAFLD #diet #fattyliver De Nucci S, Rinaldi R, Di Chito M, Donghia R, Giannuzzi V, Shahini E, Cozzolongo R, Pesole PL, Coletta S, De Pergola G, et al. The Replacement of Only One Portion of Starchy Carbohydrates with Green Leafy Vegetables Regresses Mid and Advanced Stages of NAFLD: Results from a Prospective Pilot Study. Nutrients. 2023; 15(10):2289. https://doi.org/10.3390/nu15102289 NAFLD,fatty liver diet,natural remedies,reversal,diet changes,liver health,cruciferous veggies,glucobrassicin,one serving change,mid advanced NAFLD,pilot study,replace carbs greens,leafy greens fatty liver,3 month diet challenge,fibrosis reduction swaps,manage reverse

The study found substantial differences after 3 months, with participants losing on average 10.4cm off their waist circumference (from an average 98.4cm at the start of the study to 88cm) and 4% of total body fat (from average 28.2% to 24.3%). #auricular #ear #weightloss Poster presentation PO4.085 at the European Congress on Obesity (ECO) Dublin, Ireland (17-20 May 2023) Auricular, ear, acupuncture, acupressure, appetite, metabolism, weight loss, bmi, hunger, digestion, vagus nerve, beads, acupoint stimulation

The MIT group is not the first to show that gamma frequency tactile stimulation can affect brain activity and improve motor function, but they are the first to show that the stimulation can also reduce levels of the hallmark Alzheimer’s protein phosphorylated tau, keep neurons from dying or losing their synapse circuit connections, and reduce neural DNA damage. #Vibrotactile #Alzheimers #tau Suk, H., Buie, N., Xu, G., Banerjee, A., Boyden, E. S., & Tsai, L. (2023). Vibrotactile stimulation at gamma frequency mitigates pathology related to neurodegeneration and improves motor function. Frontiers in Aging Neuroscience, 15. https://doi.org/10.3389/fnagi.2023.1129510 Neurodegenerative, dementia, Alzheimer’s, tau, somatosensory cortex, primary motor cortex, motor function, gamma frequency, 40hz, Vibrotactile stimulation, GENUS, for Gamma Entrainment Using Sensory stimuli, als, ftd, Pick disease, progressive supranuclear palsy, tauopathies, frontotemporal dementia, Parkinson’s disease

Other subclasses showed no association (P values range: 0.12–0.99), but every 10 mg/d of higher quercetin intake was associated with 35% lower odds of frailty onset (OR: 0.65; 95% CI: 0.48–0.88). #Frailty #quercetin #flavonols Oei, S., Millar, C. L., Nguyen Lily, T. N., Mukamal, K. J., Kiel, D. P., Lipsitz, L. A., Hannan, M. T., & Sahni, S. (2023). Higher intake of dietary flavonols, specifically dietary quercetin, is associated with lower odds of frailty onset over 12 years of follow-up among adults in the Framingham Heart Study. The American Journal of Clinical Nutrition. https://doi.org/10.1016/j.ajcnut.2023.04.013 Frailty, falling, weakness, quercetin, flavonols, osteoporosis, sarcopenia. Kaempferol, myricetin, aging, elderly, fisetin, strength, balance

The researchers found that taurine suppressed age-associated weight gain in female mice (even in “menopausal” mice), increased energy expenditure, increased bone mass, improved muscle endurance and strength, reduced depression-like and anxious behaviors, reduced insulin resistance, and promoted a younger-looking immune system, among other benefits. “Not only did we find that the animals lived longer, we also found that they’re living healthier lives,” Yadav says. #taurine #aging #health Singh, P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M. A., Chamoli, M., Shi, S. L., Bastos, B. L., Nair, T., Riermeier, A., Vayndorf, E. M., Wu, J. Z., Nilakhe, A., Nguyen, C. Q., Muir, M., Kiflezghi, M. G., Foulger, A., Junker, A., Devine, J., . . . Yadav, V. K. (2023). Taurine deficiency as a driver of aging. Science. https://doi.org/abn9257 Taurine, serum concentration, aging, anti-aging, disease, hypotaurine, type 2 diabetes, wbc, insulin, bmi. Metabolism, waist circumference, N-acetyl taurine, exercise, hemoglobin, platelets, circulating taurine, age-associated pathologies, lower glucose

“In a long series of studies, we have shown that increasing amounts of lutein and zeaxanthin in the retina and brain decrease glare disability and discomfort and improve chromatic contrast and visual-motor reaction time, and supplementing these compounds facilitates executive functions like problem-solving and memory. All of these tasks are particularly important for athletes,” #vision #lutein #zeaxanthin Harth, Jacob B.1; Renzi-Hammond, Lisa M.1,2; Hammond, Billy R. Jr2. A Dietary Strategy for Optimizing the Visual Range of Athletes. Exercise and Sport Sciences Reviews 51(3):p 103-108, July 2023. | DOI: 10.1249/JES.0000000000000318 Visual range, distance vision, macular pigment optical density . reaction speed, yellow pigment , blue light, contrast, visual-motor function, executive cognition, glare disability, photo stress, chromatic contrast, athletic performance, coincidence anticipation ability, carotenoid

Most of the world's population either chronically suffers from plaque and dental cavities or will develop them at some point in their lives. Toothpastes, mouthwashes, and regular checkups do their part, but more could always be done. Ben-Gurion University of the Negev scientists and their colleagues at Sichuan University and the National University of Singapore have discovered that 3,3′-Diindolylmethane (DIM), a naturally occurring molecule also known as bisindole, reduces the biofilms that produce plaque and cavities by 90%. The molecule is also found to have anti-carcinogenic properties. #DIM #Cavities #plaque Baruch Y, Golberg K, Sun Q, Yew-Hoong Gin K, Marks RS, Kushmaro A. 3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm. Antibiotics. 2023; 12(6):1017. https://doi.org/10.3390/antibiotics12061017 DIM, Cavity Fighter, S.Mutans, Oral Health, Oral Microbiome, Diindolylmethane, biofilm, teeth, tooth, cavity preventer, anti-plaque, healthy mouth, natural anti-biofilm agents, extracellular polymeric substance, toothpaste, mouthwash

Both clinical and pre-clinical animal studies have supported the therapeutic usefulness of MSM for joint diseases such as OA; however, there is no direct evidence to support prophylactic use for joint diseases or use to maintain the normal condition of joints in a healthy population. In the present study, we conducted a randomized, double-blind, placebo-controlled trial of oral consumption of MSM on mild pain of the knee joint in healthy participants. #MSM #methylsulfonylmethane #kneepain Toguchi, A., Noguchi, N., Kanno, T., & Yamada, A. (2023). Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 15(13), 2995. https://doi.org/10.3390/nu15132995 Knee pain, KOA, MSM, Methylsulfonylmethane, osteoarthritis, arthritis, mild pain, inflammation, anti-inflammatory, stiffness, knee stiffness, sulfur

This research delves into "oxymel", an ancient honey-vinegar mix, for its potential to combat infections. Vinegar, while effective alone, may harbor additional antibacterial powers beyond its acetic acid. When paired with manuka honey, vinegar showed a promising "synergy" against stubborn bacterial colonies. Pomegranate vinegar emerged as a champion for further study. Overall, this study rekindles interest in traditional remedies like oxymel, showcasing their potential for modern medicine.

In summary, the three clinical caries studies [Paszynska et al. (6), Schlagenhauf et al. (7), and the present study] as well as a number of in situ (8, 12, 13, 67) studies and in vitro studies (9, 17, 29, 39) in the field of remineralization and biofilm control, have demonstrated that hydroxyapatite serves as an efficient and safe alternative to fluoride in anticaries toothpastes for all age groups. #cavities #hydroyapatite #caries Paszynska, E., Pawinska, M., Enax, J., Meyer, F., May, T. W., Amaechi, B. T., Limeback, H., Hernik, A., Krahel, A., Kaminska, I., Stokowska, E., & Gawriolek, M. (2023). Caries-preventing effect of a hydroxyapatite-toothpaste in adults: A 18-month double-blinded randomized clinical trial. Frontiers in Public Health, 11, 1199728. https://doi.org/10.3389/fpubh.2023.1199728 Hydroxyapatite, remineralization , fluoride, fluoride alternative, cavities, caries, oral microbiome, oral heath, teeth, mouth, dentin hypersensitivity

A new randomized controlled study of people with type 2 diabetes showed that study participants who restricted eating to between noon and 8 p.m. daily lost more weight than those who reduced their overall calorie intake by counting calories. Both dieting strategies produced similar improvements in blood sugar levels. #diabetes #diet #timerestrictedeating (OR14-01-23) Effect of 8-Hour Time Restricted Eating Versus Daily Calorie Restriction on Body Weight and Glycemic Control in Adults With Type 2 Diabetes Diabetes, type 2 diabetes, diet, tre, time-restricted eating, caloric restriction, calorie restriction, weight loss, lose weight

This report investigates purple corn extract (PCE) as a potential natural remedy for dry eye disease (DED). Studies show PCE possesses antioxidant and anti-inflammatory properties, suggesting its ability to protect against DED's damaging effects. Oral PCE administration in animal models significantly improved tear production, corneal health, and goblet cell density, demonstrating its effectiveness in treating DED symptoms. These findings suggest PCE can be a safe and effective functional food for promoting eye health, particularly in DED cases, offering a promising alternative to conventional treatments. #Anthocyanin #PurpleCorn #Dryeyes Lee J-M, Choi A, Lee H-H, Park SJ, Kim B-H. Purple Corn Extract Improves Dry Eye Symptoms in Models Induced by Desiccating Stress and Extraorbital Lacrimal Gland Excision. Nutrients. 2023; 15(24):5063. https://doi.org/10.3390/nu15245063 DryEye, PurpleCornExtract, Anthocyanins, TearsOfJoy, NaturalRemedy, GobletCells, InflammationRelief, Omega3Comparison, EyeHealthFood, FutureOfEyeCare, DryEyeModels, DesiccationStress, LacrimalGlandExcision,

This study investigated the effects of consuming a combination of Bifidobacterium animalis subsp. lactis GCL2505 and inulin on abdominal fat reduction. The results showed that participants who consumed the combined beverage had significant reductions in visceral fat area and total fat area compared to the placebo group. Additionally, the intervention increased the total number of bifidobacteria in the gut and affected several lipid markers. The authors suggest that the combined intake of GCL2505 and inulin improves the intestinal environment and reduces abdominal fat through a mechanism involving short-chain fatty acids (SCFAs). Further research is needed to investigate the full mechanisms involved in this effect. Overall, the study suggests that the combined intake of GCL2505 and inulin may be a simple and effective way to reduce abdominal fat and potentially prevent metabolic abnormalities. #probiotics #weightloss #BMI Baba Y, Saito Y, Kadowaki M, Azuma N, Tsuge D. Effect of Continuous Ingestion of Bifidobacteria and Inulin on Reducing Body Fat: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study. Nutrients. 2023; 15(24):5025. https://doi.org/10.3390/nu15245025 visceral fat reduction, inulin and bifidobacteria, GCL2505 probiotic, gut health and weight loss, natural ways to reduce abdominal fat, reducing inflammation through diet, probiotics for metabolic health, improving digestion and gut microbiome, "GCL2505 and inulin combined", "Bifidobacterium animalis subsp. lactis GCL2505 study",

Researchers measured participants’ skin conditions and markers of inflammation and oxidative stress at the start of the study and at the end of each six-week period. They found that drinking muscadine wine significantly improved skin elasticity (a loss of elasticity is what causes skin to sag more as we age). In addition, the wine was associated with a decrease in water loss at the skin surface, a measurement that indicates the skin is providing a more effective barrier against damage. #skin #skinhealth #muscadine (P23-018-23) Dealcoholized Muscadine Wine Improved Skin Health, Reduced Oxidative Stress and Inflammation in Women in a Randomized Controlled Trial Skin, muscadine, skin elasticity, viscoelasticity, anti wrinkle, skin moisture, polyphenols, inflammation. Oxidative stress, anti aging, youthing, healthy skin,

When a fragrance wafted through the bedrooms of older adults for two hours every night for six months, memories skyrocketed. Participants in this study by University of California, Irvine neuroscientists reaped a 226% increase in cognitive capacity compared to the control group. The researchers say the finding transforms the long-known tie between smell and memory into an easy, non-invasive technique for strengthening memory and potentially deterring dementia. #cognition #aromatherapy #olfactory Woo, C. C., Miranda, B., Sathishkumar, M., Yassa, M. A., & Leon, M. (2023). Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults. Frontiers in Neuroscience, 17, 1200448. https://doi.org/10.3389/fnins.2023.1200448 Cognition, memory, scent, essential oils, verbal learning, dementia, aromatherapy, uncinate fasciculus, rose, orange, eucalyptus, lemon, peppermint, rosemary, lavender, gray matter, white matter, olfactory enrichment, olfactory stimulation, olfactory ability, Alzheimer’s

“This may be one of the safest and the easiest approaches to halt disease progression and protect memory in Alzheimer’s disease patients,” said Kalipada Pahan, PhD, the Floyd A. Davis, MD, Professor of Neurology and professor of neurological sciences, biochemistry and pharmacology at RUSH Medical College. #hmb #alzheimers #cognition Ramesh K. Paidi, Sumita Raha, Avik Roy, Kalipada Pahan. Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice. Cell Reports, 2023; 112717 DOI: 10.1016/j.celrep.2023.112717 β-hydroxy β-methylbutyrate, hmb, mild cognitive impairment, ppar, plaque, tangles, neuroprotective, fatty acids, blood brain barrier, peroxisome proliferator-activated receptor, memory, morphological plasticity, hippocampal neurons