BIKMAN2 LOW INSULIN PRODUCES KETONES…high insulin produces body fat

http://www.DoctorsToTrust.com
presents episode 285: Ben Bikman
at Low Carb Down Under

Shivering-induced thermogenesis...
-babies have enough brown fat to keep warm: no shivering

As we develop, relatively less of our fat is brown fat...
-more is white (storage) adipose tissue

If you have more brown fat...
-or you can induce more brown fat & it is active:
~you will be in a good place metabolically

Brown fat has more mitochondria...
-which is the site of oxidation of
~glucose (blood sugar) or lipids (fat)

Mitochondria also have the ability to pull in glucose...
-use it only to produce heat

UCP1 (Uncoupling Protein) is producing this heat

As the UCP1 produces heat, glucose comes down...
-this reduces the need for insulin, so it comes down too
-creates metabolic health

Acetyl-CoA in the liver:
-the branch point of many nutrients...
-nutrients turning into Acetyl-CoA
-Acetyl-CoA turning into nutrients:
~amino acids, glucose, fatty acids
-the liver dictates this...
-insulin is main hormone

Acetyl-CoA is a metabolite (end product of metabolism)...
-of lipid & glucose
-if insulin is high, turns Acetyl-CoA into lipid (body fat)

If insulin is low, turns Acetyl-CoA into ketones

Insulin is potent inhibitor of ketogenesis...
-this pathway is never resistant!
-insulin will always inhibit ketogenesis

But, when insulin is low, ketogenesis is happening...
-we produce ketones

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insuliniq.com

www.lowcarbdownunder.com.au

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