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BIKMAN2 LOW INSULIN PRODUCES KETONES…high insulin produces body fat
http://www.DoctorsToTrust.com
presents episode 285: Ben Bikman
at Low Carb Down Under
Shivering-induced thermogenesis...
-babies have enough brown fat to keep warm: no shivering
As we develop, relatively less of our fat is brown fat...
-more is white (storage) adipose tissue
If you have more brown fat...
-or you can induce more brown fat & it is active:
~you will be in a good place metabolically
Brown fat has more mitochondria...
-which is the site of oxidation of
~glucose (blood sugar) or lipids (fat)
Mitochondria also have the ability to pull in glucose...
-use it only to produce heat
UCP1 (Uncoupling Protein) is producing this heat
As the UCP1 produces heat, glucose comes down...
-this reduces the need for insulin, so it comes down too
-creates metabolic health
Acetyl-CoA in the liver:
-the branch point of many nutrients...
-nutrients turning into Acetyl-CoA
-Acetyl-CoA turning into nutrients:
~amino acids, glucose, fatty acids
-the liver dictates this...
-insulin is main hormone
Acetyl-CoA is a metabolite (end product of metabolism)...
-of lipid & glucose
-if insulin is high, turns Acetyl-CoA into lipid (body fat)
If insulin is low, turns Acetyl-CoA into ketones
Insulin is potent inhibitor of ketogenesis...
-this pathway is never resistant!
-insulin will always inhibit ketogenesis
But, when insulin is low, ketogenesis is happening...
-we produce ketones
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