DOM D’AGNOSTINO 3 | Ketones 101…bypass GLUT receptors, enter brain for healing
http://www.DoctorsToTrust.com
presents episode 356 | Dr Dom D’Agnostino
of CrossFit conference presentation
Pharmaceutical companies want to reverse engineer...
-the keto diet to develop a drug
Liver is production center for ketones...
-when insulin signaling suppressed (low carb intake):
~ketones are made
-fatty acids are converted into the fuels:
~acetoacetate &
~beta-hydroxybutyrate
Liver makes ketones, but does NOT use them for energy
-most cancer cells also CANNOT use ketones for energy
In the case of GLUT-1 or GLUT-3 deficiency, or in
-Alzheimer's disease
-traumatic brain injury
-ketones bypass these regulatory steps and enter the brain
-and bypasses pyruvate dehydrogenase complex (PDC)
(converts pyruvate into acetyl-CoA, used by Krebs cycle)
~so PDC Syndrome is treated by keto diet
Alzheimer's disease is glucose hypometabolism
(less uptake of glucose into the liver)
-cerebral blood flow increases 30% during
acute hyperketonemia
(low cerebral ketone uptake)
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ketonutrition.org
Original Youtube: https://youtu.be/Hs0zzox-TF0
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