Cytokines Series: Brain Derived Neurotrophic Factor -BDNF #shorts

In the brain, BDNF is expressed predominantly in the hippocampus, cortex, and synapses of the basal forebrain areas where it is vital to learning, memory, and higher thinking. BDNF is also expressed in muscles.
BDNF selectively supports the survival of primary sensory neurons, retinal ganglia and the survival and differentiation of certain cholinergic and dopaminergic neurons. It also modulates neural plasticity and predisposition to behaviors.
BDNF can recover re-innervation in the mature cerebellum thus it is applicable in trauma of the central nervous system (CNS). Both BDNF and NGF express neuroprotective effects on myelin, thus they are indicated in multiple sclerosis (MS).
Exposure to stress and the stress hormone corticosterone has been shown to decrease the expression of BDNF which can lead to depression.
On the other hand, the expression of BDNF is increased by voluntary exercise, caloric restriction, intellectual stimulation, curcumin, the neurotransmitter glutamate and various antidepressants drugs.

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DISCLAIMER: Nothing contained in this video is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only.