Cytokines Series: Nerve Growth Factor – NGF #shorts

This is the fifteenth of a series of short videos on Low Dose Medicine and in particular Cytokines. This video introduces the cytokine Nerve Growth Factor – NGF, an important nerve regenerative and repairing neurotrophine.
NGF is synthesized in the hypothalamus, pituitary, thyroid gland, testis, and it is also produced by vascular smooth muscle cells and fibroblasts.
The expression of NGF in specific neurons of the central nervous system (cortex, hippocampus) can be influenced positively by glutamate and negatively by GABA stimulating neuronal activity.
NGF stimulates the growth and differentiation of B-cells and the growth of T-cells and also promotes the proliferation of mast cells.
Vitamin D3 is potent inducer of NGF synthesis (a possible reason for vitamin D antidepressant action), while glucocorticoids are potent NGF inhibitors.
Studies have shown that NGF seems to prevent or reduce neuronal degeneration in neurodegenerative diseases. It has also been shown to promote peripheral nerve regeneration and has neuroprotective effects on myelin, thus it is indicated in multiple sclerosis (MS).
NGF seems to protect cholinergic neurons in Alzheimer's disease which is characterized by a selective degeneration of these cells.

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DISCLAIMER: Nothing contained in this video is intended nor can be taken to diagnose, treat, or cure any disease. It is for informational purposes only.