The Role of Histamine in Covid

Dr. CHetty discovered many people were suffering from a histamine/inflammatory reaction during Covid that started on Day 8.
Most treatment protocols have since added anti-histamines to their list.
It has helped a ton of people stay out of hospitals!
But, as always, I want to know the WHY. WHY did the people who reacted with a histamine response react? What was underlying this reaction? It’s super great to be able to prevent hospitalizations and deaths with simple OTC medications or supplements but my goal is always to better understand WHY, right?!?!.
My belief? It stems from an imbalance in the (WAIT FOR IT…) GUT!!!!
Bifidobacterium – a crucial, keystone gut bug plays an enormous role in managing histamine in the body naturally. When I see high histamine on the microbiome test it always coincides with low Bifido strains. Also leaky gut plays a role in allowing histamines to travel outside of the gut and enter the systemic circulation so the gut bug Akkermansia So while we can give OTC meds or even herbs to lower histamines – if we are lacking the intrinsic ability to do it ourselves we are only band-aiding.
But I also think hormones are at play because women are more predisposed to having Long Haulers than men and more predisposed to histamine intolerance in general.
I think poor estrogen detox plays a key role. We know that estrogen stimulates mast cells – the histamine releasing cells and down-regulates the enzyme that breaks down histamine so it makes sense that the inability to break down estrogens (whether male or female) has got to be a puzzle piece!
Bottom Line: If we aren’t fixing the foundations we are making real progress in health!