Premium Only Content

The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1
In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, and how all of this makes up the "Information Theory of Aging", and the difference between "biological age" and "chronological age" and how we can measure biological age through DNA methylation clocks.
Thank you to our sponsors:
Athletic Greens - https://athleticgreens.com/sinclair
InsideTracker - https://insidetracker.com/sinclair
Levels - https://levels.link/sinclair
Our Patreon page:
https://www.patreon.com/davidsinclair
Lifespan book:
https://amzn.to/3sUqurT
Dr. David Sinclair Social:
Instagram - https://www.instagram.com/davidsincla...
Twitter - https://twitter.com/davidasinclair
Facebook - https://www.facebook.com/davidsinclai...
Matthew LaPlante's Social:
Twitter - https://twitter.com/mdlaplante
Timestamps:
00:00:00 Introduction
00:03:14 Goal of the Lifespan Podcast
00:07:11 Acknowledgement of Sponsors
00:10:45 Aging is a Controllable Process that can be Slowed & Reversed
00:16:42 Organisms with Extreme Longevity
00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins
00:21:55 mTOR & Rapamycin
00:24:33 AMP-activated protein kinase (AMPK) & Metformin
00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging
00:35:33 Ex-Differentiation
00:43:30 Measuring Aging - Biological Age vs. Chronological Age
00:49:30 "No Law That Says We Have To Age"
00:50:33 Episode Summary & Key Takeaways - Why Do We Age?
00:54:00 Information Theory of Aging
00:57:59 Aging is a Medical Condition
01:01:00 Aging Myths - Telomeres & Antioxidants
01:01:55 Options for Subscription and Support
Links:
Weapon fragments in bowhead whales - https://bit.ly/3eP7rqP
Rapamycin extends lifespan in mice - https://go.nature.com/3F0yud3
Targeting Aging with Metformin (TAME) Trial - https://bit.ly/3eU9ABk
Metformin improves healthspan and lifespan in mice - https://go.nature.com/3JSRZbs
Metformin reduces all-cause mortality - https://bit.ly/3pWNiWc
Reprogramming to restore vision - https://go.nature.com/335iysI
DNA methylation age - https://bit.ly/3sUAUYB
Genome-wide methylation profiles & human aging rates - https://bit.ly/3ETPXnK
Reversal of epigenetic aging in humans - https://bit.ly/3eUior3
Danish twins study - https://bit.ly/3eToU13
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
-
1:05:55
BonginoReport
3 hours agoBiden is a BIG BULLY! - Nightly Scroll w/ Hayley Caronia (Ep.107) - 08/07/2025
33.5K17 -
1:16:24
Kim Iversen
4 hours agoAIPAC NATION: Israel First, Who Really Runs Washington?
71.6K125 -
LIVE
Nerdrotic
2 hours ago $0.70 earnedInvestigations Into Earth's Moon | Forbidden Frontier #110
462 watching -
LIVE
Quite Frankly
7 hours ago"The Unconscious Mind & Hypnosis" ft. Giulio Anselmo 8/7/25
464 watching -
1:06:01
vivafrei
3 hours agoTrumps Crackdown on the Census! Corruption in Canada, Eh! Tulsi's Interview! Carville's Apology!
32.2K15 -
15:32
AndresRestart
7 hours ago $0.11 earnedTHESE Mario 40th Anniversary Rumors Make Way More Sense Than That Collection "Leak"
6.39K1 -
2:11:45
Redacted News
4 hours agoThis is HUGE news, and neo-cons are already trying to DESTROY it | Redacted News Live
113K80 -
30:53
Kimberly Guilfoyle
6 hours agoThe Trump Doctrine Delivers, Interview with Daily Signal Producer Virginia Allen | Ep244
28.7K14 -
1:03:56
Sarah Westall
3 hours agoBy Design or Organic? Profound Culture Change Oncoming and Accelerating w/ Dr. Drew
29.3K3 -
30:00
BEK TV
21 hours agoCounter Culture Mom
3.93K