"Special Considerations about GOF Research" Dr Ralph Baric, December 2014

Found at https://www.scribd.com/document/251947132/Session-8-Special-Considerations-about-GOF-Research-Baric
Subtle: Grant Review Process
•GOF Restrictions
–Limit animal model development
–Limit reverse genetic applications
–Limit ability to make causal associations between genotype and phenotype
–Uncouple: very powerful experimental continuum
•Biochemistry and structure-function studies
•Genetic studies (validate biochemistry, role in virus replication)
•Evaluating functionality in viral pathogenesis, virus-host interactions