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Fauci: This would not be the first be the first time that a vaccine actually made people worse
"This would not be the first be the first time ... that a vaccine that looked good in initial safety [studies], actually made people worse."
FULL TRANSCRIPT
"...safety study, Mark, is to see, if I inject it in the arm, does it have some sort of idiosyncratic or bad reaction? There's another element to safety, and that is if you vaccinate someone, and they make an antibody response and then they get exposed and infected, does the response that you induce actually enhance the infection and make it worse? And the only way you'll know that is if you do an extended study, not in a normal volunteer who has no risk of infection, but in people who are out there in a risk situation.
"This would not be the first be the first time, if it happened, that a vaccine that looked good in initial safety, actually made people worse. There was the history of the respiratory syncytial virus in children, which paradoxically made the children worse. One of the HIV vaccines that we tested years ago, actually made individuals more likely to get infected. So you can't just go out there and give it, unless you feel that in the field, when someone is getting infected and exposed, being vaccinated doesn't make them worse. That's why you gotta do a trial."
NOTES
Fauci is talking about the risk of Antibody Dependent Enhancement (ADE) where non-neutralizing antibodies actually make an infection worse. This is a well-known risk, which was also seen in the dengue vaccine.
According to Fauci, we should do an EXTENDED study. Are the clinical vaccine trials of only a few months extended enough so we can know these injections are safe, before we injected it into billions of shoulders?
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