4 years ago

325

Video Karen ⁣Kington chez Stew Peters show:
https://odysee.com/@Barbotin:6/StewPeters-Karen-Kingston-graphene:d?

Présentation de Karen:
⁣
https://adelaidefreedomrally.com/wp-content/uploads/2021/08/2021.08.01-01.06-redvoicemedia-61069c71579fe.pdf

Page importante:
⁣
https://www.sinopeg.com/core-shell-structured-polyethylene-glycol-functionalized-graphene-for-energy-storage-polymer-dielectrics-combined-

mechanical-and-dielectric-performances_n28

"⁣Core-shell structured polyethylene glycol functionalized graphene for energy-storage polymer dielectrics: Combined mechanical and dielectric performances
SEPTEMBER 1,2020.
Graphene, as the thinnest, strongest and stiffest material and arranged in a honeycomb pattern structure with sp2-hybridized carbon, finds more
potential applications in modern industry than other carbonaceous allotropes; in pristine form, it is also an excellent heat and electric conductor .
However, the major obstacle in utilizing graphene, particularly for electronic applications, is its insolubility in the fully reduced state due to the
strong affinity between the graphene sheets."

⁣
https://www.sinopeg.com/2-polyethylene-glycol-2000-n-n-ditetradecylacetamide-alc-0159-cas-1849616-42-7_p477.html

⁣2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide[ALC-0159] CAS: 1849616-42-7

Shanghai ⁣National Engineering Research Center for Nanotechnology:
⁣
https://en.sjtu.edu.cn/research/centers-labs/national-engineering-research-center-for-nanotechnology

Brevet:
⁣
https://patents.google.com/patent/CN112220919A/en

"Nano coronavirus recombinant vaccine taking graphene oxide as carrier"

⁣ALC-0159 Wikipedia:
⁣
https://en.wikipedia.org/wiki/ALC-0159

Article:
⁣"Without these lipid shells, there would be no mRNA vaccines for COVID-19"
⁣
https://cen.acs.org/pharmaceuticals/drug-delivery/Without-lipid-shells-mRNA-vaccines/99/i8

Composant du vaccin Pfizer:
⁣⁣⁣
https://www.fda.gov/media/144412/download

"Each dose of the Pfizer-BioNTech COVID-19 Vaccine also includes the following ingredients:
lipids (0.43 mg (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 0.05 mg
2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, 0.09 mg 1,2-distearoyl-sn-glycero-3-
phosphocholine, and 0.2 mg cholesterol), 0.01 mg potassium chloride, 0.01 mg monobasic
potassium phosphate, 0.36 mg sodium chloride, 0.07 mg dibasic sodium phosphate dihydrate,
and 6 mg sucrose. The diluent (0.9% Sodium Chloride Injection) contributes an additional 2.16
mg sodium chloride per dose."

⁣Public Assessment Report
Authorisation for Temporary Supply
COVID-19 mRNA Vaccine BNT162b2
(BNT162b2 RNA)
concentrate for solution for injection
⁣
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/997584/COVID-19_mRNA_Vaccine_BNT162b2UKPAR_PFIZERBIONTECH

ext_of_indication_11.6.2021.pdf

"⁣Excipients
The excipients sucrose, sodium chloride, potassium chloride, dibasic sodium phosphate
dihydrate, monobasic potassium phosphate and water for injection are all of Ph. Eur. grades,
which are acceptable.
In addition to those excipients, the vaccine contains four lipids, of which two are used in
approved medicinal products (cholesterol and 1,2-distearoyl-sn-glycero-3-phosphocholine,
hereafter termed DSPC) and two are considered novel in that they have not been used in an
authorised medicinal product in the UK:
ALC-0315 ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)) and
ALC-0159 (2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide).
The lipids are intended to encapsulate the mRNA in the form of a lipid nanoparticle to aid
cell entry and stability of the RNA/lipid nanoparticles.
ALC-0315 is the functional cationic lipid component of the drug product. When incorporated
in lipid nanoparticles, it helps regulate the endosomal release of the RNA. During drug
product manufacturing, introduction of an aqueous RNA solution to an ethanolic lipid
mixture containing ALC-0315 at a specific pH leads to an electrostatic interaction between
the negatively charged RNA backbone and the positively charged cationic lipid. This
electrostatic interaction leads to encapsulation of RNA drug substance resulting with particle
formation. Once the lipid nanoparticle is taken up by the cell, the low pH of the endosome
renders the LNP fusogenic and allows the release of the RNA into the cytosol.
The primary function of the PEGylated lipid ALC-0159 is to form a protective hydrophilic
layer that sterically stabilises the LNP which contributes to storage stability and reduces nonspecific binding to proteins. As higher PEG content can reduce
cellular up"