Calm a Cat which is in Heat

An un-spayed female cat will go into heat, Usually, this involves howls, screeches, writhing, and attempts to attract or run away with male cats, In this case, calming the cat down is hard, and more importantly, it's only temporary. This is natural, normal behavior for a cat in heat, no matter how annoying it is to owners. Seek a long-term solution instead of a quick fix.