HOW Spiderman Lost His Powers in Spider-Man 2

The physical effects of PTSD can take away muscle mass and cause dozens of health complications that could be responsible for the loss of superpowers. The Film Theorists failed to address how PTSD actually affects the body in a way that would cause loss of physical abilities. His loss of Mary Jane "MJ" Watson to a Mr. Right, Harry thinking he associated with a murderer, failing school, and not being able to pay his rent put him in a state of perpetual stress. His cortisol and physiology were disrupted seriously.
https://www.ptsduk.org/10-unexpected-physical-symptoms-of-ptsd/