Houmorous Phases of Funny Faces c.1906 : First animated film recorded on standard picture film

Humorous Phases of Funny Faces is a 1906 short silent animated cartoon directed by James Stuart Blackton and generally regarded by film historians as the first animated film recorded on standard picture film.

In the cartoon, animated hand-drawn scenes appear on a chalkboard, including a clown playing with a hat and a dog jumping through a hoop. In the beginning, though, the cartoonist's hands are included, too, as he draws the first several lines on the chalkboard in standard live action. From there, the stop-motion technique is used to show what appears to be drawings completing—and then moving—by themselves with no artist on screen.

https://en.wikipedia.org/wiki/Humorous_Phases_of_Funny_Faces