Katzenjammer Kids c. 1918 : The kids make it look like the Captain is being poisoned by his wife

The Katzenjammer Kids is an American comic strip created by Rudolph Dirks in 1897 and later drawn by Harold Knerr for 35 years (1914 to 1949). It debuted December 12, 1897, in the American Humorist, the Sunday supplement of William Randolph Hearst's New York Journal. Dirks was the first cartoonist to regularly express comic characters' dialogue using speech balloons. The comic strip was turned into a stage play in 1903. It inspired several animated cartoons and was one of 20 strips included in the Comic Strip Classics series of U.S. commemorative postage stamps.

After a series of legal battles between 1912 and 1914, Dirks left the Hearst organization and began a new strip, first titled Hans and Fritz and then The Captain and the Kids. It featured the same characters seen in The Katzenjammer Kids, which was continued by Knerr. The two separate versions of the strip competed with each other until 1979, when The Captain and the Kids ended its six-decade run. The Katzenjammer Kids published its last strip on January 1, 2006, but is still distributed in reprints by King Features Syndicate, making it the oldest comic strip still in syndication and the longest-running ever.

https://en.wikipedia.org/wiki/The_Katzenjammer_Kids