Introduction of PTM - Creative Proteomics

Up to now, scientists suggested that human proteome presents significantly more complexity than the human genome. While the genome comprises 20,000-25,000 genes, the proteome is estimated at over 1 million proteins. The increase in proteomic diversity is further increased by protein post-translational modifications (PTMs).

PTMs refer to the covalent and generally enzymatic modification of proteins during or after protein biosynthesis. It denotes changes in the polypeptide chain as a result of adding distinct chemical moieties to amino acid residues. PTMs are the foundation of governing intricate cellular process, such as cell division, growth, differentiation, signaling and regulation. Also, PTMs are involved in many cellular processes including the maintenance of protein structure and integrity, regulation of metabolism & defense processes, cellular recognition and morphology alternation. Consequently, analysis of protein post-translational modifications, including the modification categories and modified sites, is particularly crucial for the study of cell biology and disease diagnostics and prevention.More information about PTM can be reached at Creative Proteomics: https://www.creative-proteomics.com/services/protein-post-translational-modification-analysis.htm