【36】新型コロナに対する免疫は粘膜バリア - 大橋眞
風邪、インフルエンザ、そしていま話題の新型コロナは、いづれも気道感染系という点て共通点があります。いま開発中の新型コロナワクチンは、抗体を作るということで効果の有無を判定されようとしています。しかしながら、抗体がはたして気道粘膜のバリアの保護に役立つのでしょうか。これまで多くのワクチンが皮下注射によって行われてきました。このような方法で、粘膜系の免疫システムを上げることは理論的に不可能です。抗体は血行性の病原体には有効かもしれませんが、気道感染する病原体が血行を使って移動するという証拠もありません。すなわち、にわか仕立てで開発したワクチンが抗体を作っても、感染を防ぐ働きがあるかということとは無関係です。
Colds, flu, and the hot new corona all have something in common in that they are respiratory tract infections. The new corona vaccine currently under development is about to be judged for its effectiveness by producing antibodies. However, do antibodies really help protect the airway mucosal barrier? So far, many vaccines have been given by subcutaneous injection. It is theoretically impossible to raise the immune system of the mucosal system in this way. Antibodies may be effective against hematogenous pathogens, but there is no evidence that respiratory tract-infecting pathogens travel using blood circulation. In other words, even if a vaccine developed with a quick tailoring produces antibodies, it has nothing to do with whether it works to prevent infection.
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