How A Single Psilocybin Dose Can Change Your Brain

How A Single Psilocybin Dose Can Change Your Brain

Oct. 22, 2025

Dr. Tracey Marks

Latest Research

Explore the latest science on what psilocybin does to your brain. This overview explains how the compound can quiet the brain's "inner narrator" (the default mode network), forge new neural connections, and open a temporary window of heightened brain flexibility. The video also covers the current state of clinical trials for treatment-resistant depression and where psilocybin stands on the path to becoming a potential medical treatment.

Important Note: The possession, use, and sale of psilocybin and psilocybin mushrooms are illegal in most parts of the world. However, there is a growing movement for decriminalization and medical research, leading to legal changes in a few specific cities and states. Always be aware of your local laws.

In summary, while the pure compound is scientifically known as psilocybin or psilocin, it is most commonly referred to by the name of the fungi that contain it: magic mushrooms or shrooms.

Chapters

0:00 – Can the brain reboot?
0:21 – How psilocybin works
1:51 – The brain’s “default mode” quiets
2:29 – New brain connections form
3:08 – The “fresh snow” effect
3:33 – Enhanced plasticity window
4:39 – How perception shifts
5:21 – Integration after treatment
6:06 – Where trials stand now
7:41 – State programs & access
8:30 – New research directions
8:50 – What to know before trying
9:51 – Why guidance matters
10:38 – Big picture summary

Reference:
Letheby, Chris, and Philip Gerrans. “Self unbound: ego dissolution in psychedelic experience.” Neuroscience of consciousness vol. 2017,1 nix016. 30 Jun. 2017, doi:10.1093/nc/nix016

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Original: https://youtu.be/5bTq3j6zPsw

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Disclaimer: All information provided on this channel is for educational purposes only and is not intended to be a substitute for professional medical advice. If you have concerns about your mental health, please consult with a qualified healthcare professional. These videos can be a helpful resource to prepare for discussions with your clinician.