Why overeating can trigger pancreatitis 🤔

Overloading the pancreas with large, fatty meals causes excessive secretion of digestive enzymes. When the pancreatic ducts fail to drain these secretions efficiently, intraductal pressure rises and zymogens (inactive digestive enzyme precursors) become prematurely activated leading to autodigestion of pancreatic tissue. Inflammatory mediators are released, vascular permeability increases, and local tissue damage occurs. If unchecked, this can give rise to systemic inflammation, risk of necrosis, and multi-organ involvement. Learn how diet, enzyme regulation, and ductal physiology intersect in this critical pathology.