NFL Week 1 DraftKings Picks 2025 | Best DFS Lineups, Ownership & Pick’em Plays

NFL is back! In this video, Pat Mayo, Tyler Tamboline and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 1 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 1. Whether you’re entering GPPs or cash games, this guide has you covered.

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What You’ll Learn in This Video:
* Best DraftKings DFS picks for NFL Week 1 (2025)
* Lineup strategy & game theory for tournaments and cash
* Ownership breakdown & leverage plays
* Underdog Pick’em Week 1 strategy

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Show Index

00:00 Intro
00:41 TNF Takeaways
16:51 Week 1 DK Main Slate Overview
19:27 Optimal + CLE/CIN
42:11 MIA/IND
54:05 DEN Stack
59:51 WAS/NYG
1:07:46 ARZ/NO

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