Saints vs Cardinals Breakdown: Can Rattler Lead Saints to an Upset?

The New Orleans Saints open the 2025 NFL season at home against the Arizona Cardinals, entering as underdogs by a touchdown. Rookie QB Spencer Rattler makes his debut under the spotlight, while Kyler Murray and the Cardinals look to start fast. In this video, we break down key matchups on both sides of the ball, from the Saints’ defense containing Murray to whether Rattler can lead an efficient Saints offense. We’ll also review the latest injury reports and give our prediction for the outcome.
Can the Saints shock the NFL with a Week 1 upset?

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