Lifespan: Why We Age - and Why We Don't Have To by David A Sinclair, PhD | Health & Longevity

📖 Lifespan: Why We Age - and Why We Don't Have To by David A Sinclair, PhD with Matthew D. LaPlante (2019)
👉 See Book on Amazon | https://amzn.to/3UoC6zG

Redefining Aging: Insights from Dr. David Sinclair's Groundbreaking Research

In this episode, we delve into the transformative ideas presented in Dr. David A. Sinclair's book 'Lifespan: Why We Age – and Why We Don't Have To.' Discover how his personal experiences fueled a scientific quest to redefine aging and explore the concept of aging as a treatable disease. We break down Sinclair's theory of aging being a loss of analog information, the role of sirtuins in DNA repair, and the impact of epigenetic noise. Learn about lifestyle interventions like calorie restriction, intermittent fasting, and exercise, as well as promising anti-aging drugs such as rapamycin, metformin, and NAD boosters. We also discuss the ethical, social, and economic implications of extending human lifespan and maintaining health into older age. Finally, Sinclair's personal regimen provides a practical glimpse into applying these scientific insights to everyday life.

00:00 Introduction to Aging and Dr. Sinclair's Insights
00:42 Personal Stories that Sparked a Scientific Quest
02:23 The Information Theory of Aging
04:06 Epigenetic Noise and DNA Damage
10:33 Lifestyle Interventions for Longevity
13:30 Pharmaceuticals and Molecules for Anti-Aging
16:57 Cutting-Edge Technologies and Future Prospects
20:06 Ethical and Societal Implications of Longevity
23:28 Dr. Sinclair's Personal Regimen and Final Thoughts

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