The Role of Ubiquitination in Thyroid Hormone Regulation

The Role of Ubiquitination in Thyroid Hormone Regulation

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More T4 doesn’t mean better thyroid function. When T4 levels are too high—especially if you’re not converting it well—you’ll end up with high reverse T3 and low active T3. This means your medication might be working against you. Too much T4 can trigger “ubiquitination” of deiodinase 2, the enzyme that converts T4 into usable T3. The result? Less T3 inside the cells and more symptoms, despite normal labs.

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