The Role of GABA in Health and Well-Being - Interview with Dr. Scott Sherr

In this interview, Dr. Scott Sherr, director of integrative hyperbaric medicine and health optimization at Hyperbaric Medical Solutions, reviews the action of gamma aminobutyric acid (GABA) and the role it plays in your physical and mental health.

Most modern people live in constant fight-or-flight mode and find it hard to relax. GABA helps put you into parasympathetic mode, thereby promoting relaxation and stress reduction, indirectly.

Glutamate is the primary excitatory neurotransmitter and GABA the main inhibitory neurotransmitter. These two are always working in conjunction with each other to maintain a balance. Glutamate converts into GABA in your brain. If you have trouble converting glutamate into GABA, you’ll have excitatory-like symptoms, as the glutamate over-accumulates.

Underlying factors that can prevent the efficient conversion of glutamate to GABA include a lack of cofactors (B6 and magnesium), and a lack of the enzyme glutamate decarboxylase, which is what converts the glutamate to GABA. Two common problems that inhibit the function of this enzyme are infections and chronic stress.

Mentally, GABA deficiency is associated with anxiety, fear, depression, short temper, phobias, impulsiveness, disorganization, addictions, schizophrenia and OCD. IBS, diarrhea, hypertension, tinnitus, chronic pain, migraines, allergies, frequent urination, flushing, sweating, salt cravings and muscle tension are physical symptoms of GABA deficiency.

Supplements that help raise GABA include N-nicotinoyl GABA or nanoliposomal varieties of GABA, kava, valerian root and cannabinoids such as CBD and CBG. Other ways to increase GABA include exercise, and things like meditation, mindfulness training, breathing exercises and yoga, which raise GABA by putting you in a parasympathetic state.

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