"South Park: The End of Obesity" (24May2024)

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☆A doctor informs fourth graderEric Cartmanand his motherLianethat his obesity is a threat to his health. When Liane says that proper diet and exercise has not worked for him, the doctor recommends a diabetes drug calledsemaglutide, which has been shown to help people lose weight. This prompts Cartman to fantasize about being able to viciously insult people with impunity without fear of being mocked for his weight, and even going all the way toPakistanto continue this. However, insurance companies only cover the drug for diabetes, and are too expensive for Liane. The doctor prescribes that Cartman listen to the music ofLizzo, who frequently encouragesbody positivity.
☆This leaves Cartman despondent, so his friends,Butters StotchandKyle Broflovski, accompany him to an insurance company office. However, when they request to make a claim with a dejected-looking claims officer, they are sent on a labyrinthine journey through the bureaucracy of the American health care system. They ultimately decide to make it themselves after learning the raw semaglutide powder can be purchased cheaply from a factory in India and mixed withbiostaticwater purchased locally. Their other friends,Stan MarshandKenny McCormick, join them in this scheme.
☆Meanwhile,Randy Marshobserves many local mothers wearing crop-tops after attaining toned midriffs after losing weight with semaglutide, a recurring visual gag in the episode. After they see Randy wearing one of his daughter's crop-tops (which he has donned in order to embarrass her into dressing more conservatively), they invite him to a semaglutide-sharing party. Randy begins taking the drug himself, believing it to be a party drug that leaves him with neither ahangovernor an appetite, though this leaves his wifeSharonfeeling self-conscious about her weight. She begins taking Lizzo, but it causes her to defecate from her ears. The doctor tells her she has developed "diabeardes", a form of diabetes that afflicts the ears. This means she now qualifies for semaglutide, which he prescribes her.
☆After the homemade semaglutide appears to be successful in curbing Cartman's appetite, Kyle decides to produce more in order to benefit people who cannot afford it. However, news of this draws the ire of asugar industrycartel consisting of mascots ofbreakfast cerealsand sugary snacks. In addition, when a government crackdown in response to semaglutide abuse leaves the mothers without their supply, they and Randy begin robbing pharmacies, and then Kyle and his friends. The boys' supply is then destroyed when the sugar mascots, posing as "body positivity activists", attack the Indian factory, murdering the workers and burning the building to the ground.
☆Kyle finds and purchases a truckload of semaglutide powder from another supplier in North Carolina, but it iscarjackedby Randy and the mothers. However, Randy realizes that what the mothers are doing is wrong and steals the truck without them. A violent chase ensues, which is joined by the boys, and then by the sugary mascots. Though Kenny is killed, Randy and the boys escape their pursuers, but when they open the truck, they find that the only thing inside is the insurance claims agent, who tells them that the insurance company works with the supplier, which will mean another trip through the American healthcare system.
☆Before Sharon takes her first injection, Randy stops her, confessing that he has been using it himself. Surprised at how sympathetic she is to his desire to use it, he realizes that she is the coolest woman he knows, and does not want her to change at all. Deciding that semaglutide drugs are bad, he invites her to go to aHoliday Innand takeMDMAtogether like they did in college. Meanwhile at school, Kyle gives a speech calling for the end offat shaming, which garners a positive reception. Overjoyed, Cartman proceeds to insult his classmates and everyone else in town without being mocked in return for his weight, and books a flight to Pakistan to continue this.