rs5882 G;G (CETP Gene VV genotype)

Original description:

rs5882 in the CETP gene referred to as ILE405VAL and RSAI405V has been related to ageing and exceptional long life. A study in Ashkenazi Jews showed that individuals homozygotic for the G allele have significantly longer lifespans.

New research also indicates that G homozygotes have an average of 70% less risk of dementia and Alzheimer's disease. (Snpedia)

rs5882 (CETP VV genotype) strongly correlates with exceptional longevity, particularly through protective cardiovascular effects mediated by larger HDL and LDL particles and reduced CETP levels.

CETP (Cholesteryl Ester Transfer Protein) is a plasma glycoprotein that plays a central role in lipid metabolism, particularly in the transfer of cholesterol esters and triglycerides among different lipoprotein particles, such as HDL, LDL, and VLDL. CETP directly influences lipoprotein particle size and composition, significantly impacting cardiovascular health and metabolic function.

Acting as a critical regulator of cholesterol homeostasis, CETP facilitates the transfer of cholesteryl esters from high-density lipoproteins (HDL, "good cholesterol") to very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL, "bad cholesterol"), in exchange for triglycerides. This process typically reduces HDL cholesterol concentrations and particle size while promoting LDL cholesterol enrichment - factors commonly associated with increased cardiovascular risk.

Individuals with some CETP variants exhibit improved vascular function, reduced inflammation, and greater resistance to age-related diseases, contributing positively to longevity and metabolic health.

This field will install this snp in you. I found a way to do it in a safe and tailored way, so you shouldn't worry about hidden risks. The effect should be permanent.

2-3 times a day is a safe amount.

You don't need to use it after the first week, but once a year after that might be a good idea.

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