Methylene Blue: Biohacker's Delight, or Playing With Fire

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00:00:00 The Origin of Methylene Blue

00:08:54 The Entry of Methylene Blue Into Medicine

00:13:59 From Malaria to Many Uses in Medicine

00:26:20 How Methylene Blue Works

A Redox-Reactive Dye

The Blue Bottle Experiment

Methylene Blue Radicals, Photoexcited States, and Demethylated Metabolites

Methylene Blue Can Oxidize and Reduce Many Targets

Methylene Blue Can Rewire the Mitochondrial Respiratory Chain

Rewiring the Respiratory Chain Does Not Make It Better

Methylene Blue Increases Hydrogen Peroxide

Hydrogen Peroxide Kills Microbes, Has Hormetic Benefits, But Is Still Ultimately Toxic

Methylene Blue Causes Redox Cycling of Hemoglobin

Methylene Blue Is a Strong Monoamine Oxidase A Inhibitor

Methylene Blue Inhibits Nitric Oxide Synthase

Mechanistic Conclusions

02:09:14 Is Methylene Blue Fundamentally Hormetic?

02:15:06 Methylene Blue Fails in Alzheimer’s, and Causes a Worrisome Side Effect

02:23:57 Whether Methylene Blue Helps Or Hurts Depends on Whether You Need It

02:30:16 Natural Alternatives for Hormesis and Rewiring the Respiratory Chain

02:33:27 Who Should Use Methylene Blue?