Dihydroberberine Review

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https://youtu.be/2Efn5L2N61k

Disclaimer: This podcast is for informational and educational purposes only and does not constitute medical advice. The content is based on publicly available research, including information accessed through Notebook LM from the U.S. National Library of Medicine (PubMed), and BMI Doctors. This information should not be used to diagnose, treat, cure, or prevent any medical condition. The efficacy and safety of supplements can vary, and ongoing research may impact current understanding. Always consult with a qualified healthcare provider for advice specific to your health needs, especially before making changes to medication or trying new supplements. The views expressed do not replace professional medical guidance.

Summary

The provided texts explore dihydroberberine (dhBBR), a derivative of the natural alkaloid berberine (BBR). Research highlights dhBBR's enhanced bioavailability and efficacy compared to BBR in treating type 2 diabetes and related conditions like obesity and insulin resistance in animal models and humans. Studies investigate dhBBR's mechanisms of action, including its effects on mitochondrial function and gut microbiota, and assess its safety profile. Further research also examines the pharmacokinetics and metabolism of both BBR and dhBBR, exploring various administration methods (oral, transdermal) and their impact on drug efficacy.

Sources

https://pubmed.ncbi.nlm.nih.gov/35010998/
https://pubmed.ncbi.nlm.nih.gov/35868606/
https://pubmed.ncbi.nlm.nih.gov/34386321/
https://pubmed.ncbi.nlm.nih.gov/34253428/
https://pubmed.ncbi.nlm.nih.gov/33623004/
https://pubmed.ncbi.nlm.nih.gov/31401380/
https://pubmed.ncbi.nlm.nih.gov/29579096/
https://pubmed.ncbi.nlm.nih.gov/38891813/
https://pubmed.ncbi.nlm.nih.gov/18285556/
https://pubmed.ncbi.nlm.nih.gov/21355331/
https://pubmed.ncbi.nlm.nih.gov/20663675/
https://pubmed.ncbi.nlm.nih.gov/26174047/
https://pubmed.ncbi.nlm.nih.gov/33493658/
https://pubmed.ncbi.nlm.nih.gov/36189746/
https://www.mdpi.com/1422-0067/25/11/5625

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