Exploring the Anticancer Potential of Fenbendazole: A Review of Anecdotal Case Reports and Emerging Evidence (2025) https://www.onedaymd.com/2025/01/anticancer-potential-fenbendazole.html A compilation of 80 case reports across various cancer types, including breast, lung, colorectal, and pancreatic cancers While these anecdotal accounts suggest potential anticancer effects of fenbendazole, the lack of controlled clinical trials necessitates caution. Healthcare professionals should be consulted before considering fenbendazole as a treatment option. There has been growing popularity in recent years for the use of Fenbendazole (FBZ) as a single agent or supplementary therapeutic Methods Reports were categorized by cancer type, and outcomes were assessed based on self-reported measures such as tumor regression, remission status, and overall survival. Results These findings, while compelling, must be interpreted cautiously due to the inherent limitations of the data sources. Breast Cancer Eight cases of breast cancer reported outcomes such as tumor shrinkage or remission. A majority of these cases involved early to moderate-stage disease, with some patients combining fenbendazole with standard treatments like chemotherapy and hormonal therapy. One notable case involved a patient with metastatic triple-negative breast cancer achieving remission after six months of fenbendazole use, alongside a ketogenic diet and immune-supportive supplements. Lung Cancer Nine cases, highlighted improved survival rates and tumor regression. One patient with advanced NSCLC demonstrated significant tumor shrinkage within three months of incorporating fenbendazole alongside checkpoint inhibitors. Colorectal Cancer In nine cases, patients reported tumor reduction, remission, or disease stabilization. The most striking outcome was from a patient with stage IV colorectal cancer achieving no evidence of disease (NED) status after integrating fenbendazole with conventional therapies and dietary modifications. Pancreatic Cancer Eight cases involved pancreatic cancer, an aggressive malignancy with limited treatment options. Outcomes were generally less pronounced than in other cancers Other Cancer Types Reports included melanoma, prostate cancer, glioblastoma, and ovarian cancer, with mixed outcomes. Some patients indicated significant clinical improvement, including reduced tumor markers and alleviated symptoms. Combination Therapies, with conventional cancer treatments (e.g., chemotherapy, radiotherapy, immunotherapy), ? making fenbendazole’s specific effects. Supplement Use: Many used supportive supplements, (e.g., D3, C), zinc, curcumin, ? synergistic effects Consistency and Dosage: Regular and sustained use of fenbendazole appeared to correlate with better-reported outcomes. Dosages ranged from 222 mg (a standard veterinary dose) to 1 gram per day, depending on individual protocols. Limitations Sample size, (N=80) Self-Reported Data Concurrent Therapies Potential Mechanisms of Action Microtubule Disruption Metabolic Effects, (inhibits glucose uptake in cancer cells) Immune Modulation, (may enhance immune responses) Discussion Consistency of positive outcomes across diverse cancer types suggests a potential biological effect that merits further investigation. The pattern of case reports also suggests that fenbendazole may exhibit broad-spectrum anticancer properties. It is imperative that patients consult healthcare professionals before considering fenbendazole as a treatment option. Future Directions Controlled Clinical Trials Mechanistic Studies Combination Therapy Research Conclusion The consistency of anecdotal outcomes, supported by plausible preclinical mechanisms, positions fenbendazole as a promising candidate for further investigation in oncology.

Dr. William Makis MD. Radiologist, Oncologist, Cancer Researcher, Author of 100+ publications. Top Substack Author. Links for Dr. Makis makismd.substack.com https://x.com/MakisMD Email: [email protected]

10 stories they chose not to tell you this week. #10 - Senators who took the most Big Pharma cash were the most hostile to RFK Jr. in his confirmation hearing. #9 - Karoline Leavitt Forces the Media to Eat Their Words in Brutal White House Smackdown #8 - House Minority Leader Hakeem Jeffries (D-N.Y.) makes a chilling statement that sounds like a call for insurrection against Trump. #7 - Peer-Reviewed Study Finds Irrefutable Evidence Supporting Immediate Market Withdrawal of COVID-19 “Vaccines” #6 - Stephen Miller Schools Jake Tapper on His “Who’s Going to Pick the Crops” Argument as Trump Deports Illegals #5 - Trump Targets DEI Hiring Practices at FAA After Deadly Crash in Washington DC #4 - Bill Maher Goes Full RFK Jr. in a Scorching Takedown of America’s Failing Healthcare System #3 - “I Don’t Really Care, Margaret”: Vance Shuts Down CBS Host Over Unvetted Migrants #2 - Trump’s FCC Chair Launches Investigation Into NPR and PBS #1 - Kash Patel drops the mic on Democrat Senator with a devastating response to her entrapment questions. SUPPORT THE SHOW THROUGH OUR SPONSORS: Good Ranchers: https://goodranchers.com/VNN Home Title Lock: https://hometitlelock.com/VNN My Patriot Supply: https://bit.ly/Prepare-With-VNN The Wellness Company: https://twc.health/blackout

10 stories they chose not to tell you this week. #10 - Actor exposes cancer breakthrough suppressed by Big Pharma. #9 - Pennsylvania Senator John Fetterman breaks the internet with two explosive statements on Fox News. #8 - Mollie Hemingway shares a hilarious take on the “gift” that Liz Cheney and the January 6 Committee gave to Republicans. #7 - Shocking new study finds catastrophic neurological and psychiatric damage from the COVID jabs. #6 - “This is not normal.” A leaked memo reveals an unusual “Presidential Inauguration Medical Personnel Support Deployment Request.” While you’re here, don’t forget to subscribe to this page for more weekly news roundups. #5 - Insane Joe Rogan clip predicting the Los Angeles wildfire goes mega-viral. #4 - The UK government opens investigations into Elon Musk’s TWEETS about grooming gangs—instead of the grooming gang issue itself. #3 - Greenland is “ready to talk” with Trump as “status quo” becomes “no longer an option.” #2 - Joe Rogan shuts down Mark Zuckerberg’s bogus claim about COVID. #1 - The New Zealand government pushes to codify “medical mandates” into law. SUPPORT THE SHOW THROUGH OUR SPONSORS: Good Ranchers: https://goodranchers.com/VNN Home Title Lock: https://hometitlelock.com/VNN My Patriot Supply: https://bit.ly/Prepare-With-VNN The Wellness Company: https://twc.health/blackout

Introducing the top ten stories they chose not to tell you this week. #10 - Cancer remission achieved with low-cost drug, a jaw-dropping case series reveals. #9 - Democrat Megadonor Says the Way Kamala Harris Blew Through More Than a Billion Dollars ‘Disqualifies Her Forever’ #8 - Rothschild Billionaire Dies in Mysterious House Fire #7 - Australians Stunned by Professor's Warning on Sky News: “These Vaccines Were Not Vaccines…” #6 - Billionaire Democrat Describes “Alarming” Meeting with Biden Admin That Prompted His Trump Endorsement #5 - Walmart Nukes DEI as Anti-Woke Crusader Sends “Shockwaves Across Corporate America” #4 - Tucker Carlson Issues Chilling Warning About the Deep State’s Next Big Move #3 - NIH Chief Confesses COVID Health Initiatives Were Completely Made Up #2 - Half a Million Migrant Kids Lost in Biden’s Border Crisis—Where Are They? #1 - Elon Musk Says DOGE Will Audit the IRS SUPPORT THE SHOW THROUGH OUR SPONSORS: Good Ranchers: https://goodranchers.com BrickHouse Nutrition • Field of Greens: https://brickhousenutrition.com/pages/vnn • LEAN Weight Loss: https://leanvnn.com My Patriot Supply: https://bit.ly/Prepare-With-VNN The Wellness Company: https://twc.health/blackout

Repositioning of Anthelmintic Drugs for the Treatment of Cancers of the Digestive System https://pmc.ncbi.nlm.nih.gov/articles/PMC7404055/ Tumours of the digestive system, their incidence continues to increase. The process discovering and validating novel and effective drugs against these malignancies, lengthy and costly Drug repositioning (drug repurposing), finding new uses for approved drugs, provides the opportunity to expedite promising anti-cancer agents into clinical trials. Some classes of anthelmintics Infections caused by parasitic worms (helminths) Meds have shown pronounced anti-tumor activities Ability to target key oncogenic signal transduction pathways. Benzimidazoles Some have been successfully tested for the treatment of gastrointestinal, liver and pancreatic cancers. Mebendazole Blocks tubulin polymerization, compromise microtubule function Seen to inhibit cell growth and invasion of ascites cell line derived from a primary gastric tumor, whether used alone or in combination with chemotherapeutic Treatment was also successfully tested in five CRC cell lines, showed no cytotoxic activity against three cell lines with non-malignant phenotype Induced remission of lung and lymph node metastases, and a partial remission of liver metastases, in a patient with refractory metastatic colon cancer Showed anti-cancer properties in the treatment of hepatocellular carcinoma Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers https://pmc.ncbi.nlm.nih.gov/articles/PMC9862092/ Albendazole Cytostatic effect on the human cancer cell lines Potential anti-cancer agent also for the treatment of HCC Pancreatic cancer lines Positive mice studies, some early human studies Ivermectin CRC, gastric cancer (vitro and in vivo) Ivermectin, a potential anticancer drug derived from an antiparasitic drug https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/ Mechanisms of action IVM induces different programmed cell death patterns, e.g. apoptosis. Forms of cancer Breast cancer Digestive system cancer Gastric cancer Hepatocellular carcinoma Urinary system cancer Renal cell carcinoma Prostate cancer Hematological cancer Leukemia Reproductive system cancer Cervical cancer Ovarian cancer Brain glioma Glioblastoma Respiratory system cancer Nasopharyngeal carcinoma Lung cancer Melanoma Right to Try https://trumpwhitehouse.archives.gov/briefings-statements/president-donald-j-trump-sign-right-try-legislation-fulfilling-promise-made-expand-healthcare-options-terminal-americans/ Kathleen T Ruddy, MD https://twitter.com/DocRuddy

Fenbendazole Enhancing Anti-Tumor Effect: A Case Series (2021) https://www.scitechnol.com/peer-review/fenbendazole-enhancing-antitumor-effect-a-case-series-2Kms.php?article_id=14307&fbclid=IwAR0tYpTZb4fp2_AO8e_WGWM5mcqv-RNfI-5SID9OWDcRiwHyHmQBKsjeSKk Full PDF with radiology https://www.scitechnol.com/peer-review/fenbendazole-enhancing-antitumor-effect-a-case-series-P3SV.pdf Background Fenbendazole (FBZ) is a cheap and readily available anti-parasitic commonly used in veterinary medicine. FBZ belongs to the benzimidazole drug class which destabilize microtubules through a mechanism similar to the anti-oncogenic vinca alkaloids. Although there are no reported cases in the literature, there have been several anecdotal stories published on website blogs with individuals praising its ability to treat a wide variety of cancers. Case Presentations Three patients with various genitourinary malignancies, who demonstrated complete response after receiving FBZ therapy, as a single or supplementary chemotherapeutic agent. In two patient scenarios, they had experienced progression of metastatic disease despite multiple lines of therapy prior to initiation of FBZ. No side effects from FBZ were reported. Conclusion FBZ appears to be a potentially safe and effective antineoplastic agent, that can be repurposed for human use in treating genitourinary malignancies. Further research is necessary to define the role of FBZ as a chemotherapeutic option. Details FBZ is a cheap anti-helminthic medication commonly used in veterinary practice, However, despite multiple anecdotal stories and news outlet reports for its efficacy in treating metastatic cancer, the clinical literature behind utilizing FBZ as a potential anti-neoplastic agent remains nonexistent. Case 1 A 63-year-old Caucasian male presented with flank pain, rapid weight loss, and transient fever. Abdominal Computed Topography (CT) revealed a 3 cm left solid renal mass. Renal Cell Carcinoma (RCC) Traditional drugs used then discontinued One month after discontinuation, repeat MRI showed increase in size of recurrent left renal mass, pancreatic head and body lesion He also started alternative therapy with FBZ 1 gm three times per week at the suggestion of one of his friends with head/neck cancer. Interval MRI imaging found near complete resolution of the previously noted left renal mass, as well as decrease in pancreatic head/body and pelvic bone lesion Serial imaging for the past 10 months have not shown any evidence of recurrence or metastatic disease. He has continued taking FBZ without any reported side effects. Case 2 A 72-year-old caucasian male Urethral lesion Distal penectomy Pathology showing high-grade urothelial carcinoma of the urethra Four years later, the patient developed a cough, 5.5 cm × 4.0 cm left hilar mass and a left upper lobe nodule, with multiple abnormal lymph nodes Bronchoscopy with biopsy revealed squamous carcinoma, (probable primary) Chemotherapy given Developed progressive retroperitoneal disease The patient opted for complementary therapy with FBZ 1 gram orally three days per week, vitamin E 800 mg daily, curcumin 600 mg daily, and CBD oil Serial CTs from the past 9 months showed progressive decrease in size to 0.5 cm × 0.5 cm, complete radiographic response. Case 3 A 63-year-old Caucasian female CT imaging revealed a 7.5 cm right lateral bladder mass with extensions Hydronephrosis requiring percutaneous nephrostomy. Transurethral Resection of Bladder Tumor (TURBT) demonstrated a large necrotic mass, pathology confirming urothelial carcinoma with 85% squamous and 2% sarcomatoid histology. 6 cycles over the course of 4 months, along with concurrent FBZ 1 gram three times weekly. Follow-up CT revealed no evidence of disease with minimal residual thickening in the right inferior bladder wall She declined to proceed with cystectomy and remains on surveillance with no evidence of progression. Discussion We have three patients with different primary genitourinary tumors who demonstrated complete response after receiving FBZ therapy. This raises the question of how effective FBZ can be as an anti-oncogenic agent and merits further investigation. FBZ belongs to a class of microtubule-destabilizing agents The ability to disrupt microtubule polymerization,to induce mitotic arrest, and promote apoptosis. ? p53 activation The variety of mechanisms by which this class of medications functions may help limit the propagation of resistant cancer cell lines FBZ has been safely utilized as an anti-parasitic for various different animal species and could be repurposed for treating human malignancies. Several benzimidazoles have already shown promise for human repurposing. Mebendazole has been shown in case reports to be efficacious with few side effects in patients with metastatic adrenocortical carcinoma and metastatic colon cancer Mebendazole, effective in animal studies for glioblastoma Flubendazole, animal studies, hematologic malignancies Given evidence of high tolerability and applicability to a wide range of malignancies, this warrants further investigation for FBZ and other benzimidazoles as safe chemotherapeutic options. Conclusion There remains limited data with few published studies on the anti-oncogenic properties of FBZ. Other benzimidazoles have been studied to a larger extent, and the knowledge can be drawn upon to help guide future FBZ studies, and to gauge the efficacy of this drug class whether as a solitary agent or in combination therapy. Given the potential benefits of FBZ with what seems to be a limited toxicity profile, further research is warranted to evaluate the clinical settings in which this medication may be beneficial and repurposed, for patients with progressive genitourinary malignancy and possibly in other malignant settings as well.

Viewers share their experiences of their approaches to cancer treatment. Ivermectin I am a stage IV metastatic prostate cancer survivor 5 1/2 years now. Menbendazole, ivermectin, atorvastatin, metformin....PSA went from 1900 to undetectable for past 4 years. Oncologist couldn't care less I am still alive. How can we get the word out faster? My friend's dad had terminal bladder cancer and had months to live. He started taking ivermectin and now he's cancer free within six months. we have the right to eat sugar, drink alcohol, smoke tobacco, etc. BUT oh NO...don't take a drug we can't make into MONEY! I believe right to try should not apply to only terminal patients. But it's a start. My wife just died from cancer. The Drs refused to give her ivermectin. Whatever happened to "your body"? Not to be sarcastic, but I really mean that. I first became aware of Ivermectin in 1977 when I was working at a local feed mill, farmers would mix in Ivermectin, which came in 50 lb. bags, in their cattle feed to keep the cows from getting worms! My dad had TB and the docs were arguing cos it hadnt been trialled. He said ill try it I'm desd anyway and signed for He was the first test case for streptomyacin and survived another 60 years. Exactly - why the heck should anyone lord it over desperate people Of course, you are correct. Can you imagine the mindset of someone who does not agree with this? Pure tyranny. Government should not interfere with being born or dying. These experiences are right out of the hand of God. Fenbendazole (Fen ben) Fenbendazole gave a friend 5 more years, she’d been directed to hospice, 30 days later 100% cancer free with fenbendazole. I have high grade DCIS (Ductal carcinoma in situ), I’ve been using fenben and ivermectin for 6 months and have shrunk my tumour by over a cm My husband is taking febendazole. He has glioblastoma, stage 4 brain tumor....He was having terrible seizures until he started taking this. Hasn't had one in 16 months. Also now at 3 years with this terminal condition and outlived his 12 months prognosis massively. And he remains well. The tumour simply isn't growing Fenbendazole cured my dog of "terminal" squamous cell carcinoma. FANTASTIC stuff!!!!! My dog had 2 months to live, I gave her fenben and 2.5 years later she's FINE!!!! My Mum was given 6 months to live in March, with pancreatic cancer. Refused all treatments and took 222 mg of Fenbendazole 6 days per week. 8 months later is still healthy and tumour has not increased in size. Doctors not interested to know how this happened because she didn’t want their treatments. Thank you. Thank you. Thank you. I had bladder cancer. I had surgery to remove the tumor. Did six BCG treatments. Never had chemo or radiation. And I started taking fen. Ben. When I went back for my 18-month checkup they thought it came back. They found something in my bladder. They did biopsies. The biopsies all came back negative. Surgeon had them retested because he was convinced that what he saw were cancer cells. Biopsies came back negative. I know that Fen Ben has kept me cancer free now for 2 and 1/2 years. Thank you for sharing this information. I share it with people that are diagnosed with cancer … I had a friend who was diagnosed with stage 4 throat cancer, had chemo, had radiation and he started taking this. His last checkup. He was told things are in remission and he is singing again. There is an easy way to handle this. My beloved dog was diagnosed 2 years ago with terminal cancer that had spread widely. She was given at best 6 months, yet she is still with me and happy and healthy. I put her on FenBen right after the diagnosis and I give full credit to the FenBen for her still being here enjoying a good quality of life. No real side effects that I've noticed, perhaps some watery stools on occasion. Last year, I was diagnosed with a small grade 1 uterine cancer, this was done via biopsy. They gave me quite a bit of time between the diagnosis and my surgery for hysterectomy. They didn't seem to have a big sense of urgency. So I decided to see what I could do on my own to help this. So I started some natural therapies and also added the Panacur (Fen Ben). About 2 and half months later I had my surgery. They test whilst on the table and also test lymph nodes to make sure all is clear. My pathology report was all clear, no cancer at all! I was the luckiest girl at the cancer center that day. They surmised that the biopsy removed the cancer. That could be true but what are the chances? It could be the initial biopsy was wrong, or the Panacur worked. But who knows? Thank you Dr. Campbell for spreading the word. My cat has lymphoma and my vet said (almost 5 years ago now) that he should be put down because he only had weeks to live. Took him home and researched and found out about fen ben and he’s doing good! I continue supplements and fen ben