The Hidden Risks of Radiation in Cancer Treatment

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Radiation therapy, a common cancer treatment, might be doing more than targeting tumors—it could be promoting metastasis. How does this happen? Let’s break it down:

- Circulating Tumor Cells: Radiation can increase the number of tumor cells circulating in the body, which may seed new tumors in distant sites.

- Tumor Bed Effect: Known as the bystander effect, radiation damages not just the tumor but also the healthy cells around it, altering their epigenetics and the surrounding matrix.

- Immune System Alteration: It modifies the immune response, including M2 macrophage polarization in the tumor microenvironment, which stimulates pro-inflammation and helps the cancer evade immune detection.

- Increased Angiogenesis: Radiation can enhance the growth of new blood vessels, providing a pathway for cancer cells to spread.

- Activation of Dormant Sites: It can awaken distant dormant micrometastatic sites, a process supported by the concomitant resistance theory.

- Forced Mutations and Phenotypic Shifts: Radiation can induce genetic mutations and changes in cancer cell characteristics, promoting resilience.

- Cancer Stem Cell Transformation: It may encourage the transformation of normal cells into cancer stem cells, which are particularly tough to treat.

- Metabolic Shifts: Such as the Warburg effect, where cancer cells metabolize glucose more efficiently, aiding their growth and survival.

At Williams Cancer Institute, we take a different approach. Our non-radiation ablative techniques, like Pulse Electric Field Therapy, activate and train the immune system locally, allowing it to attack distant, untreated tumor sites systemically.

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