Mebendazole: The Repurposed Powerhouse in Cancer Care

Did you know this antiparasitic medication is making waves in cancer treatment? Not only is Mebendazole a repurposed medication, but it’s also synergistic with immune checkpoint therapies—changing the game for cancer patients.

Here’s how:

🧬 Reprograms Tumor-Associated Macrophages (TAMs):

* Shifts TAMs from pro-tumor M2 types to anti-tumor M1 types.

* This reduces immunosuppressive signals (like IL-10 & TGF-beta), which cancers use to evade the immune system.

Immune Boosting & Tumor Targeting:

* Reduces STAT3 & NF-kB activity to weaken tumor defenses.

* Inhibits angiogenesis by reducing VEGF—cutting off the tumor’s blood supply.

* Lowers infiltration of TAMs into the tumor microenvironment and directly attacks cancer cells by decreasing chemotactic recruiting factors.

Why It Matters:

* Activates innate immunity.

* Enhances T-cell responses.

* Overcomes immunotherapy resistance.

* Synergizes with immune checkpoint therapies for greater impact.

Ready to join the repurposed medication revolution?

Go to Off-ScriptRX.com today to schedule an appointment with a medical professional and learn if Mebendazole is right for you.

Supporting Evidence:

* Rubin J, Mansoori S, Blom K, et al. Mebendazole stimulates CD14+ myeloid cells to enhance T cell activation in cancer models. Oncotarget. 2018;9(56):31671-31684.
* Mukhopadhyay T, Sasaki J, Ramesh R, Roth JA. Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo. Clin Cancer Res. 2002;8(9):2963-2969.
* Guerini AE, Triggiani L, Maddalo M, et al. Mebendazole as a candidate for drug repurposing in oncology: an extensive review of current literature. Cancers (Basel). 2019;11(9):1284.
* Kumari N, Choi SH. Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies. J Exp Clin Cancer Res. 2022;41(1):68.

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