The Reason Venom is so afraid of Deadpool💀

1. Deadpool's Role in Venom's Origins (Comic Book Canon)
In Deadpool: Back in Black, it’s revealed that before bonding with Eddie Brock, the Venom symbiote briefly bonded with Deadpool. Deadpool's chaotic personality left a lasting impact on the symbiote. The experience was so intense and unhinged that the symbiote, after separating from Deadpool, carried a sort of "trauma" or fear of him.

Deadpool’s unpredictable nature, combined with his constant internal monologue and erratic behavior, overwhelmed the symbiote. Venom prefers hosts that can maintain a more stable bond, and Deadpool was the opposite of that.

2. Deadpool’s Unpredictability
Deadpool is infamous for his recklessness, immortality, and ability to break the fourth wall. This makes him an unpredictable and uncontrollable host for the Venom symbiote, which thrives on symbiosis and a shared purpose. Deadpool's madness disrupts the symbiote's connection, which is why Venom is wary of him.