Cancer in a Post-2019 World: A Turbocharged Threat

If you have cancer, you need to understand that cancer is now more dangerous, feeding off its own exhaust and turbocharging its growth—just like a high-performance engine.

Here’s how:

🚩 Spike Protein Metastatic Map: The spike protein, now widespread, binds to TLR4 and lipopolysaccharides, triggering systemic inflammation straight from the gut and setting the stage for cancer.

🚩 Platelet Aggregation & Immune Evasion: Systemic inflammation hyperactivates and aggregates platelets, creating a protective shield for circulating tumor cells. These platelets make it harder for the immune system to detect and destroy these cells, boosting survival as they circulate the body.

🚩 Endothelial Damage & Invasion: Spike proteins damage the endothelium and form a platelet spine, allowing tumor cells to invade and establish distant micrometastatic sites—fueling the spread of cancer.

New challenges require new strategies, and understanding this turbocharged cancer mechanism can help drive the right approach.

👉 To dive deeper into these critical shifts in cancer and the most recent medical innovations, check out my new Pre-Scribed podcast through the link in my bio.

Supporting evidence:
- Russell, C.D., Lone, N.I. & Baillie, J.K. Comorbidities, multimorbidity and COVID-19. Nat Med 29, 334–343 (2023). https://doi.org/10.1038/s41591-022-02156-9
- Li YS, Ren HC, Cao JH. Correlation of SARS‑CoV‑2 to cancer: Carcinogenic or anticancer? (Review). Int J Oncol. 2022 Apr;60(4):42. doi: 10.3892/ijo.2022.5332.
- Petruk G, Puthia M, Petrlova J, Samsudin F, Strömdahl AC, Cerps S, Uller L, Kjellström S, Bond PJ, Schmidtchen AA. SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity. J Mol Cell Biol. 2020 Oct 12;12(12):916-932. doi: 10.1093/jmcb/mjaa067.
- Brandão SCS, Ramos JOX, Dompieri LT, Godoi ETAM, Figueiredo JL, Sarinho ESC, Chelvanambi S, Aikawa M. Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities? Cytokine Growth Factor Rev. 2021 Apr;58:102-110. doi: 10.1016/j.cytogfr.2020.09.002.
- Zong, Z., Wei, Y., Ren, J. et al. The intersection of COVID-19 and cancer: signaling pathways and treatment implications. Mol Cancer 20, 76 (2021). https://doi.org/10.1186/s12943-021-01363-1
- Puhm F, Allaeys I, Lacasse E, Dubuc I, Galipeau Y, Zaid Y, Khalki L, Belleannée C, Durocher Y, Brisson AR, Wolberg AS, Langlois MA, Flamand L, Boilard E. Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells. Blood Adv. 2022 Jun 28;6(12):3593-3605. doi: 10.1182/bloodadvances.2022007444.
- Lichtenberger LM, Vijayan KV. Is COVID-19-Induced Platelet Activation a Cause of Concern for Patients with Cancer? Cancer Res. 2021 Mar 1;81(5):1209-1211. doi: 10.1158/0008-5472.CAN-20-3691

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