Repositioning of Anthelmintic Drugs for the Treatment of Cancers of the Digestive System https://pmc.ncbi.nlm.nih.gov/articles/PMC7404055/ Tumours of the digestive system, their incidence continues to increase. The process discovering and validating novel and effective drugs against these malignancies, lengthy and costly Drug repositioning (drug repurposing), finding new uses for approved drugs, provides the opportunity to expedite promising anti-cancer agents into clinical trials. Some classes of anthelmintics Infections caused by parasitic worms (helminths) Meds have shown pronounced anti-tumor activities Ability to target key oncogenic signal transduction pathways. Benzimidazoles Some have been successfully tested for the treatment of gastrointestinal, liver and pancreatic cancers. Mebendazole Blocks tubulin polymerization, compromise microtubule function Seen to inhibit cell growth and invasion of ascites cell line derived from a primary gastric tumor, whether used alone or in combination with chemotherapeutic Treatment was also successfully tested in five CRC cell lines, showed no cytotoxic activity against three cell lines with non-malignant phenotype Induced remission of lung and lymph node metastases, and a partial remission of liver metastases, in a patient with refractory metastatic colon cancer Showed anti-cancer properties in the treatment of hepatocellular carcinoma Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers https://pmc.ncbi.nlm.nih.gov/articles/PMC9862092/ Albendazole Cytostatic effect on the human cancer cell lines Potential anti-cancer agent also for the treatment of HCC Pancreatic cancer lines Positive mice studies, some early human studies Ivermectin CRC, gastric cancer (vitro and in vivo) Ivermectin, a potential anticancer drug derived from an antiparasitic drug https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/ Mechanisms of action IVM induces different programmed cell death patterns, e.g. apoptosis. Forms of cancer Breast cancer Digestive system cancer Gastric cancer Hepatocellular carcinoma Urinary system cancer Renal cell carcinoma Prostate cancer Hematological cancer Leukemia Reproductive system cancer Cervical cancer Ovarian cancer Brain glioma Glioblastoma Respiratory system cancer Nasopharyngeal carcinoma Lung cancer Melanoma Right to Try https://trumpwhitehouse.archives.gov/briefings-statements/president-donald-j-trump-sign-right-try-legislation-fulfilling-promise-made-expand-healthcare-options-terminal-americans/ Kathleen T Ruddy, MD https://twitter.com/DocRuddy