Premium Only Content

New vitamin D paper
Vitamin D: A key player in COVID‐19 immunity and lessons from the pandemic to combat immune‐evasive variants
https://link.springer.com/article/10.1007/s10787-024-01578-w
As of July 2024
775,754,322 confirmed cases of COVID-19
13,578,710,228 vaccine doses had been administered
It is unclear why some patients develop severe symptoms while others do not,
literature suggests a role for vitamin D.
Vitamin D plays a crucial role in the infection or in ameliorating the severity of symptoms.
VDD is associated with increased hospitalization of severely ill patients and increased levels of COVID-19-caused mortality.
The mechanism of action of vitamin D and vitamin D deficiency (VDD) is well understood.
Vitamin D levels and genetic variations in the vitamin D receptor (VDR) gene significantly impact the severity and out- comes of COVID-19,
especially in the infections caused by Delta and Omicron variants.
Furthermore, VDD causes immune system dysregulation upon infection with SARS-CoV-2,
indicating that vitamin D sufficiency is crucial in fighting against COVID-19 infection.
Potential role as a prophylactic and treatment adjunct.
Immunomodulatory and anti-inflammatory effects of vitamin D
Ability to enhance the efficacy of new antiviral drugs
Large- scale randomized trials are required to reach a definitive conclusion.
Mechanisms of action
Macrophages activated to produce defensive proteins and stimulate naïve T cells
Activate T lymphocytes and mature B lymphocytes into plasma cells
Prevents inflammation, vasoconstriction, and fibrosis of the lungs.
Prevents excess release of cytokines from macrophages
Prevents excessive CRP production in the liver
Vit D can reduce viral replication
Vitamin D can protect against ARDS, the main death-causing complication of COVID-19
Seven out of nine studies reviewed by Yisak
https://pubmed.ncbi.nlm.nih.gov/33447107/
have indicated a crucial role in vitamin D status in COVID-19 infection, prognosis, and mortality.
Vitamin D dose
To decrease the risk of contracting a new infection,
people at high risk of COVID-19 to take 10,000 IU d−1 of vitamin D for a few weeks,
followed by 5000 IU d−1 to raise the concentrations of the active form of vitamin D.
Blood levels
Levels below 12 ng/mL indicate severe deficiency.
Levels between 12 and 20 ng/mL suggest deficiency
Treatment recommended for levels below 30 ng/mL
Optimal levels are 30–60 ng/mL,
Recommended prophylactic dose
0–1 years, 400 IU/day (10 mcg)
> 1 year, 600 IU (15 mcg)
> 8 years, half an adult dose
Adults, 800– 2000 IU of cholecalciferol
Routine toxicity monitoring is unnecessary for doses under 10,000 IU/day
-
13:10
Dr. John Campbell
1 month agoSpike and Disease
17.1K72 -
2:46:27
Laura Loomer
7 hours agoEP151: Democrats Meet With Terror Tied Islamic Group During Government Shutdown
20.9K16 -
3:02:06
TimcastIRL
6 hours agoPortland Police PROTECT Antifa From DHS Arrest, Trump Admin Says SEND IN THE GUARD | Timcast IRL
211K125 -
2:49:50
Barry Cunningham
6 hours agoPRESIDENT TRUMP SPEAKS TO THE PRESS...NO DEALS! DO YOU CARE IF THE GOVERNMENT STAYS SHUT DOWN?
37.8K33 -
1:37:24
Tundra Tactical
4 hours ago $4.92 earned🚨🚨Emergency Gun News!!!!🚨🚨 Did Glock Just Cave To Liberal Pressure?? Current Glocks Done?
22.8K4 -
1:02:57
Sarah Westall
7 hours agoStructure of the World has Changed and Getting Back to Basics w/ Stacy Washington
39.7K10 -
6:34
Buddy Brown
9 hours ago $4.96 earnedWatch What Happens When WELFARE QUEENS Get Denied FOOD STAMPS! | Buddy Brown
30.9K28 -
Drew Hernandez
16 hours agoCHARLIE KIRK TRIAL JUDGE ISSUES GAG ORDER & U.S. MARSHAL ILLEGAL ALIEN SHOOTOUT?
38.7K9 -
2:54:05
DLDAfterDark
5 hours ago $1.46 earnedIs Glock Anti 2A?? Glocks Terrible Recent Decisions & More
17.9K15 -
1:58:02
tminnzy
5 hours agoLAST REMAINING BLACK OPS 6 PLAYER 🦁
16.9K1